Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa
Background: The pathogenesis of Eating Disorders is still unknown. However, a growing body of evidence shows that there are changes in cytokine levels and an alteration in the stress response in patients with anorexia nervosa (AN). For this reason, we decided to test whether there are differences in...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/125817 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/125817 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.89-008.441.42 616.89 Adolescents Anorexia nervosa Biomarkers Cytokines Impulsivity Inflammation Oxidative stress Purging Bioquímica (Medicina) Psiquiatría Inmunología 3211 Psiquiatría 2403 Bioquímica |
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Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosaCaso Fernández, Javier RubénGraell, MonserratNavalón, AidaMac-Dowell Mata, Karina SoledadGutiérrez, SilviaSoto, MartaLeza Cerro, Juan CarlosCarrasco Perera, José LuisDíaz Marsa, Marina Francisca616.89-008.441.42616.89AdolescentsAnorexia nervosaBiomarkersCytokinesImpulsivityInflammationOxidative stressPurgingBioquímica (Medicina)PsiquiatríaInmunología3211 Psiquiatría2403 BioquímicaBackground: The pathogenesis of Eating Disorders is still unknown. However, a growing body of evidence shows that there are changes in cytokine levels and an alteration in the stress response in patients with anorexia nervosa (AN). For this reason, we decided to test whether there are differences in immune parameters involved in the regulation of the inflammatory response between female adolescents with AN and healthy adolescents. Methods: The sample 27 drug-naïve AN patients the study sample included 27 AN patients at a very early stage of the disease and 23 healthy controls. Plasma and peripheral blood mononuclear cells (PBMCs) were obtained for biochemical study. Results: Plasma levels of the pro-inflammatory cytokines TNF-α and IL-1β were significantly increased in patients with AN, while the levels of prostaglandins PGE2 (proinflammatory) and 15d-PGJ2, (anti-inflammatory) were lower compared with controls. Protein expression in PBMCs of cyclooxygenase-2 (COX-2) and the activated forms of the mitogen-activated protein kinases p38 and ERK were also increased in the AN group. Expression levels of the anti-inflammatory factor peroxisome proliferator-activated receptor gamma (PPARγ) were significantly decreased in patients. Plasma levels of lipid peroxidation markers -TBARS- were not increased in patients with AN. Components of the biochemical inflammatory response (COX-2, PGE2, TBARS, 15d-PGJ2, ERK, p65 NFκB) and glucocorticoid receptor -GR- expression and the scores on the impulsivity measures in the BARRATT, EDI and BITE questionnaires showed a significant correlation within the AN patients group. Conclusions: The results for female adolescent patients with AN indicate that there is a dysfunction of intra- and intercellular inflammatory pathways characterized by higher levels of pro-inflammatory parameters in plasma and a decrease in one of the controlling cytoplasmic-nuclear pathways implicated in their modulation (i.e. PPARγ) with, at this very early stage of the disease, no effect on oxidative stress markers plasma levels. Most notably, higher severity of illness (restrictive and purging behaviour) correlated with higher levels of inflammatory markers.ElsevierUniversidad Complutense de Madrid20192019-09-1120192019-09-11journal articlehttp://purl.org/coar/resource_type/c_6501CVoRhttp://purl.org/coar/version/c_e19f295774971610info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/125817reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Not available SAF2016-75500-R ORIGEN Y CONSECUENCIAS DE LA INFLAMACION EN FASES TEMPRANAS DE PSICOSIS. UN ESTUDIO TRASLACIONALMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available PI13%2F00781 "Estudio multicéntrico de disregulación emocional y su relación con la activación en el EEG y con la respuesta inflamatoria en los TCA: Caracterización endofenotípica"open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1258172026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| title |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| spellingShingle |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa Caso Fernández, Javier Rubén 616.89-008.441.42 616.89 Adolescents Anorexia nervosa Biomarkers Cytokines Impulsivity Inflammation Oxidative stress Purging Bioquímica (Medicina) Psiquiatría Inmunología 3211 Psiquiatría 2403 Bioquímica |
| title_short |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| title_full |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| title_fullStr |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| title_full_unstemmed |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| title_sort |
Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa |
| dc.creator.none.fl_str_mv |
Caso Fernández, Javier Rubén Graell, Monserrat Navalón, Aida Mac-Dowell Mata, Karina Soledad Gutiérrez, Silvia Soto, Marta Leza Cerro, Juan Carlos Carrasco Perera, José Luis Díaz Marsa, Marina Francisca |
| author |
Caso Fernández, Javier Rubén |
| author_facet |
Caso Fernández, Javier Rubén Graell, Monserrat Navalón, Aida Mac-Dowell Mata, Karina Soledad Gutiérrez, Silvia Soto, Marta Leza Cerro, Juan Carlos Carrasco Perera, José Luis Díaz Marsa, Marina Francisca |
| author_role |
author |
| author2 |
Graell, Monserrat Navalón, Aida Mac-Dowell Mata, Karina Soledad Gutiérrez, Silvia Soto, Marta Leza Cerro, Juan Carlos Carrasco Perera, José Luis Díaz Marsa, Marina Francisca |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
616.89-008.441.42 616.89 Adolescents Anorexia nervosa Biomarkers Cytokines Impulsivity Inflammation Oxidative stress Purging Bioquímica (Medicina) Psiquiatría Inmunología 3211 Psiquiatría 2403 Bioquímica |
| topic |
616.89-008.441.42 616.89 Adolescents Anorexia nervosa Biomarkers Cytokines Impulsivity Inflammation Oxidative stress Purging Bioquímica (Medicina) Psiquiatría Inmunología 3211 Psiquiatría 2403 Bioquímica |
| description |
Background: The pathogenesis of Eating Disorders is still unknown. However, a growing body of evidence shows that there are changes in cytokine levels and an alteration in the stress response in patients with anorexia nervosa (AN). For this reason, we decided to test whether there are differences in immune parameters involved in the regulation of the inflammatory response between female adolescents with AN and healthy adolescents. Methods: The sample 27 drug-naïve AN patients the study sample included 27 AN patients at a very early stage of the disease and 23 healthy controls. Plasma and peripheral blood mononuclear cells (PBMCs) were obtained for biochemical study. Results: Plasma levels of the pro-inflammatory cytokines TNF-α and IL-1β were significantly increased in patients with AN, while the levels of prostaglandins PGE2 (proinflammatory) and 15d-PGJ2, (anti-inflammatory) were lower compared with controls. Protein expression in PBMCs of cyclooxygenase-2 (COX-2) and the activated forms of the mitogen-activated protein kinases p38 and ERK were also increased in the AN group. Expression levels of the anti-inflammatory factor peroxisome proliferator-activated receptor gamma (PPARγ) were significantly decreased in patients. Plasma levels of lipid peroxidation markers -TBARS- were not increased in patients with AN. Components of the biochemical inflammatory response (COX-2, PGE2, TBARS, 15d-PGJ2, ERK, p65 NFκB) and glucocorticoid receptor -GR- expression and the scores on the impulsivity measures in the BARRATT, EDI and BITE questionnaires showed a significant correlation within the AN patients group. Conclusions: The results for female adolescent patients with AN indicate that there is a dysfunction of intra- and intercellular inflammatory pathways characterized by higher levels of pro-inflammatory parameters in plasma and a decrease in one of the controlling cytoplasmic-nuclear pathways implicated in their modulation (i.e. PPARγ) with, at this very early stage of the disease, no effect on oxidative stress markers plasma levels. Most notably, higher severity of illness (restrictive and purging behaviour) correlated with higher levels of inflammatory markers. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-09-11 2019 2019-09-11 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 CVoR http://purl.org/coar/version/c_e19f295774971610 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/125817 |
| url |
https://hdl.handle.net/20.500.14352/125817 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Not available SAF2016-75500-R ORIGEN Y CONSECUENCIAS DE LA INFLAMACION EN FASES TEMPRANAS DE PSICOSIS. UN ESTUDIO TRASLACIONAL Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available PI13%2F00781 "Estudio multicéntrico de disregulación emocional y su relación con la activación en el EEG y con la respuesta inflamatoria en los TCA: Caracterización endofenotípica" |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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Docta Complutense |
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