HDL-Cholesterol and Triglycerides Dynamics

Metabolic syndrome (MetS) is a complex cluster of interrelated metabolic disorders that significantly elevate the risk of cardiovascular disease, making it a pressing public health concern worldwide. Among the key features of MetS, dyslipidemia-characterized by altered levels of high-density lipopro...

ver descrição completa

Detalhes bibliográficos
Autores: Alcover, Sebastian|||0000-0003-3699-1769, Ramos-Regalado, Lisaidy|||0009-0004-3512-8474, Girón Martínez, Gabriela Obdulia|||0009-0009-4753-0985, Muñoz-García, N., Vilahur, Gemma|||0000-0002-2828-8873
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:322583
Acesso em linha:https://ddd.uab.cat/record/322583
https://dx.doi.org/urn:doi:10.3390/antiox14040434
Access Level:acceso abierto
Palavra-chave:HDL
Antioxidant activity
Atherosclerosis
Cardiovascular disease
Insulin resistance
Lipid metabolism
Metabolic syndrome
Reverse cholesterol transport
Triglycerides
id ES_c3aef3b430758ebdb36dfe6a82e891be
oai_identifier_str oai:ddd.uab.cat:322583
network_acronym_str ES
network_name_str España
repository_id_str
spelling HDL-Cholesterol and Triglycerides DynamicsEssential Players in Metabolic SyndromeAlcover, Sebastian|||0000-0003-3699-1769Ramos-Regalado, Lisaidy|||0009-0004-3512-8474Girón Martínez, Gabriela Obdulia|||0009-0009-4753-0985Muñoz-García, N.Vilahur, Gemma|||0000-0002-2828-8873HDLAntioxidant activityAtherosclerosisCardiovascular diseaseInsulin resistanceLipid metabolismMetabolic syndromeReverse cholesterol transportTriglyceridesMetabolic syndrome (MetS) is a complex cluster of interrelated metabolic disorders that significantly elevate the risk of cardiovascular disease, making it a pressing public health concern worldwide. Among the key features of MetS, dyslipidemia-characterized by altered levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)-plays a crucial role in the disorder's progression. This review aims to elucidate the intricate interplay between HDL-C and TG within the context of lipid metabolism and cardiovascular health, while also addressing the detrimental impact of various cardiovascular risk factors and associated comorbidities. The dynamics of HDL-C and TG are explored, highlighting their reciprocal relationship and respective contributions to the pathophysiology of MetS. Elevated levels of TGs are consistently associated with reduced concentrations of HDL-C, resulting in a lipid profile that promotes the development of vascular disease. Specifically, as TG levels rise, the protective cardiovascular effects of HDL-C are diminished, leading to the increased accumulation of pro-atherogenic TG-rich lipoproteins and low-density lipoprotein particles within the vascular wall, contributing to the progression of atheromas, which can ultimately result in significant ischemic cardiovascular events. Ultimately, this paper underscores the significance of HDL and TG as essential targets for therapeutic intervention, emphasizing their potential in effectively managing MetS and reducing cardiovascular risk.Universitat Autònoma de Barcelona 22025-01-0120252025-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/322583https://dx.doi.org/urn:doi:10.3390/antiox14040434reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-128891OB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1480open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3225832026-06-06T12:50:31Z
dc.title.none.fl_str_mv HDL-Cholesterol and Triglycerides Dynamics
Essential Players in Metabolic Syndrome
title HDL-Cholesterol and Triglycerides Dynamics
spellingShingle HDL-Cholesterol and Triglycerides Dynamics
Alcover, Sebastian|||0000-0003-3699-1769
HDL
Antioxidant activity
Atherosclerosis
Cardiovascular disease
Insulin resistance
Lipid metabolism
Metabolic syndrome
Reverse cholesterol transport
Triglycerides
title_short HDL-Cholesterol and Triglycerides Dynamics
title_full HDL-Cholesterol and Triglycerides Dynamics
title_fullStr HDL-Cholesterol and Triglycerides Dynamics
title_full_unstemmed HDL-Cholesterol and Triglycerides Dynamics
title_sort HDL-Cholesterol and Triglycerides Dynamics
dc.creator.none.fl_str_mv Alcover, Sebastian|||0000-0003-3699-1769
Ramos-Regalado, Lisaidy|||0009-0004-3512-8474
Girón Martínez, Gabriela Obdulia|||0009-0009-4753-0985
Muñoz-García, N.
Vilahur, Gemma|||0000-0002-2828-8873
author Alcover, Sebastian|||0000-0003-3699-1769
author_facet Alcover, Sebastian|||0000-0003-3699-1769
Ramos-Regalado, Lisaidy|||0009-0004-3512-8474
Girón Martínez, Gabriela Obdulia|||0009-0009-4753-0985
Muñoz-García, N.
Vilahur, Gemma|||0000-0002-2828-8873
author_role author
author2 Ramos-Regalado, Lisaidy|||0009-0004-3512-8474
Girón Martínez, Gabriela Obdulia|||0009-0009-4753-0985
Muñoz-García, N.
Vilahur, Gemma|||0000-0002-2828-8873
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv HDL
Antioxidant activity
Atherosclerosis
Cardiovascular disease
Insulin resistance
Lipid metabolism
Metabolic syndrome
Reverse cholesterol transport
Triglycerides
topic HDL
Antioxidant activity
Atherosclerosis
Cardiovascular disease
Insulin resistance
Lipid metabolism
Metabolic syndrome
Reverse cholesterol transport
Triglycerides
description Metabolic syndrome (MetS) is a complex cluster of interrelated metabolic disorders that significantly elevate the risk of cardiovascular disease, making it a pressing public health concern worldwide. Among the key features of MetS, dyslipidemia-characterized by altered levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)-plays a crucial role in the disorder's progression. This review aims to elucidate the intricate interplay between HDL-C and TG within the context of lipid metabolism and cardiovascular health, while also addressing the detrimental impact of various cardiovascular risk factors and associated comorbidities. The dynamics of HDL-C and TG are explored, highlighting their reciprocal relationship and respective contributions to the pathophysiology of MetS. Elevated levels of TGs are consistently associated with reduced concentrations of HDL-C, resulting in a lipid profile that promotes the development of vascular disease. Specifically, as TG levels rise, the protective cardiovascular effects of HDL-C are diminished, leading to the increased accumulation of pro-atherogenic TG-rich lipoproteins and low-density lipoprotein particles within the vascular wall, contributing to the progression of atheromas, which can ultimately result in significant ischemic cardiovascular events. Ultimately, this paper underscores the significance of HDL and TG as essential targets for therapeutic intervention, emphasizing their potential in effectively managing MetS and reducing cardiovascular risk.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/322583
https://dx.doi.org/urn:doi:10.3390/antiox14040434
url https://ddd.uab.cat/record/322583
https://dx.doi.org/urn:doi:10.3390/antiox14040434
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-128891OB-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1480
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418816806584320
score 15,811543

Registos relacionados