Inflammatory Animal Models of Parkinson's Disease

Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral im...

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Detalles Bibliográficos
Autores: García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Venero Recio, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/146320
Acceso en línea:https://hdl.handle.net/11441/146320
https://doi.org/10.3233/JPD-213138
Access Level:acceso abierto
Palabra clave:Parkinson’s disease
Animal models
Microglia
Inflammation
Substantia nigra
Lipopolysaccharide
Thrombin
Dextran sulfate sodium
Adenovirus
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spelling Inflammatory Animal Models of Parkinson's DiseaseGarcía Revilla, JuanHerrera Carmona, Antonio JoséMartínez de Pablos, RocíoVenero Recio, José LuisParkinson’s diseaseAnimal modelsMicrogliaInflammationSubstantia nigraLipopolysaccharideThrombinDextran sulfate sodiumAdenovirusAccumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral immune cells to the degeneration of the nigrostriatal system and help develop potential therapies for PD. In this review, we have summarised the main PD immune models. From a historical perspective, we highlight first the main features of intranigral injections of different pro-inflammogens, including lipopolysaccharide (LPS), thrombin, neuromelanin, etc. The use of adenoviral vectors to promote microglia-specific overexpression of different molecules in the ventral mesencephalon, including -synuclein, IL-1β, and TNF, are also presented and briefly discussed. Finally, we summarise different models associated with peripheral inflammation whose contribution to the pathogenesis of neurodegenerative diseases is now an outstanding question. Illustrative examples included systemic LPS administration and dextran sulfate sodium-induced colitis in rodents.Ministerio de Ciencia e Innovación RTI 2018-098830-B-I00Junta de Andalucía P18-RT-1372, US-1264806IOS PressBioquímica y Biología MolecularMinisterio de Ciencia, Innovación y Universidades (MICINN). EspañaJunta de Andalucía2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/146320https://doi.org/10.3233/JPD-213138reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of Parkinson's Disease, 12, S165-S182.RTI 2018-098830-B-I00P18-RT-1372US-1264806https://doi.org/10.3233/JPD-213138info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1463202026-06-17T12:51:07Z
dc.title.none.fl_str_mv Inflammatory Animal Models of Parkinson's Disease
title Inflammatory Animal Models of Parkinson's Disease
spellingShingle Inflammatory Animal Models of Parkinson's Disease
García Revilla, Juan
Parkinson’s disease
Animal models
Microglia
Inflammation
Substantia nigra
Lipopolysaccharide
Thrombin
Dextran sulfate sodium
Adenovirus
title_short Inflammatory Animal Models of Parkinson's Disease
title_full Inflammatory Animal Models of Parkinson's Disease
title_fullStr Inflammatory Animal Models of Parkinson's Disease
title_full_unstemmed Inflammatory Animal Models of Parkinson's Disease
title_sort Inflammatory Animal Models of Parkinson's Disease
dc.creator.none.fl_str_mv García Revilla, Juan
Herrera Carmona, Antonio José
Martínez de Pablos, Rocío
Venero Recio, José Luis
author García Revilla, Juan
author_facet García Revilla, Juan
Herrera Carmona, Antonio José
Martínez de Pablos, Rocío
Venero Recio, José Luis
author_role author
author2 Herrera Carmona, Antonio José
Martínez de Pablos, Rocío
Venero Recio, José Luis
author2_role author
author
author
dc.contributor.none.fl_str_mv Bioquímica y Biología Molecular
Ministerio de Ciencia, Innovación y Universidades (MICINN). España
Junta de Andalucía
dc.subject.none.fl_str_mv Parkinson’s disease
Animal models
Microglia
Inflammation
Substantia nigra
Lipopolysaccharide
Thrombin
Dextran sulfate sodium
Adenovirus
topic Parkinson’s disease
Animal models
Microglia
Inflammation
Substantia nigra
Lipopolysaccharide
Thrombin
Dextran sulfate sodium
Adenovirus
description Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral immune cells to the degeneration of the nigrostriatal system and help develop potential therapies for PD. In this review, we have summarised the main PD immune models. From a historical perspective, we highlight first the main features of intranigral injections of different pro-inflammogens, including lipopolysaccharide (LPS), thrombin, neuromelanin, etc. The use of adenoviral vectors to promote microglia-specific overexpression of different molecules in the ventral mesencephalon, including -synuclein, IL-1β, and TNF, are also presented and briefly discussed. Finally, we summarise different models associated with peripheral inflammation whose contribution to the pathogenesis of neurodegenerative diseases is now an outstanding question. Illustrative examples included systemic LPS administration and dextran sulfate sodium-induced colitis in rodents.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/146320
https://doi.org/10.3233/JPD-213138
url https://hdl.handle.net/11441/146320
https://doi.org/10.3233/JPD-213138
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Parkinson's Disease, 12, S165-S182.
RTI 2018-098830-B-I00
P18-RT-1372
US-1264806
https://doi.org/10.3233/JPD-213138
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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