Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between bloo...

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Autores: Zamora-Ros, Raul, Luján Barroso, Leila, Achaintre, David, Franceschi, Silvia, Kyrø, Cecilie, Overvad, Kim, Tjønneland, Anne, Truong, Thérèse, Lecuyer, Lucie, Boutron-Ruault, Marie-Christine, Katzke, Verena, Johnson, Theron S., Schulze, Matthias B., Trichopoulou, Antonia, Peppa, Eleni, Vecchia, Carlo La, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Quirós, José Ramón, Rodríguez Barranco, Miguel, Amiano, Pilar, Chirlaque, María Dolores, Ardanaz, Eva, Almquist, Martin, Hennings, Joakim, Vermeulen, Roel, Wareham, Nicholas J., Tong, Tammy Y. N., Aune, Dagfinn, Byrnes, Graham, Weiderpass, Elisabete, Scalbert, Augustin, Rinaldi, Sabina, Agudo, Antonio
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172181
Acceso en línea:https://hdl.handle.net/2445/172181
Access Level:acceso abierto
Palabra clave:Càncer
Nutrició
Polifenols
Cancer
Nutrition
Polyphenols
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spelling Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) studyZamora-Ros, RaulLuján Barroso, LeilaAchaintre, DavidFranceschi, SilviaKyrø, CecilieOvervad, KimTjønneland, AnneTruong, ThérèseLecuyer, LucieBoutron-Ruault, Marie-ChristineKatzke, VerenaJohnson, Theron S.Schulze, Matthias B.Trichopoulou, AntoniaPeppa, EleniVecchia, Carlo LaMasala, GiovannaPala, ValeriaPanico, SalvatoreTumino, RosarioRicceri, FulvioSkeie, GuriQuirós, José RamónRodríguez Barranco, MiguelAmiano, PilarChirlaque, María DoloresArdanaz, EvaAlmquist, MartinHennings, JoakimVermeulen, RoelWareham, Nicholas J.Tong, Tammy Y. N.Aune, DagfinnByrnes, GrahamWeiderpass, ElisabeteScalbert, AugustinRinaldi, SabinaAgudo, AntonioCàncerNutricióPolifenolsCancerNutritionPolyphenolsBackground: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.Oxford University Press (OUP)2020info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/172181Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1093/ajcn/nqaa277The American Journal of Clinical Nutrition, 2020https://doi.org/10.1093/ajcn/nqaa277(c) Zamora-Ros et al., 2020info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1721812026-05-27T06:46:51Z
dc.title.none.fl_str_mv Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
title Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
spellingShingle Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Zamora-Ros, Raul
Càncer
Nutrició
Polifenols
Cancer
Nutrition
Polyphenols
title_short Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
title_full Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
title_fullStr Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
title_full_unstemmed Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
title_sort Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
dc.creator.none.fl_str_mv Zamora-Ros, Raul
Luján Barroso, Leila
Achaintre, David
Franceschi, Silvia
Kyrø, Cecilie
Overvad, Kim
Tjønneland, Anne
Truong, Thérèse
Lecuyer, Lucie
Boutron-Ruault, Marie-Christine
Katzke, Verena
Johnson, Theron S.
Schulze, Matthias B.
Trichopoulou, Antonia
Peppa, Eleni
Vecchia, Carlo La
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Skeie, Guri
Quirós, José Ramón
Rodríguez Barranco, Miguel
Amiano, Pilar
Chirlaque, María Dolores
Ardanaz, Eva
Almquist, Martin
Hennings, Joakim
Vermeulen, Roel
Wareham, Nicholas J.
Tong, Tammy Y. N.
Aune, Dagfinn
Byrnes, Graham
Weiderpass, Elisabete
Scalbert, Augustin
Rinaldi, Sabina
Agudo, Antonio
author Zamora-Ros, Raul
author_facet Zamora-Ros, Raul
Luján Barroso, Leila
Achaintre, David
Franceschi, Silvia
Kyrø, Cecilie
Overvad, Kim
Tjønneland, Anne
Truong, Thérèse
Lecuyer, Lucie
Boutron-Ruault, Marie-Christine
Katzke, Verena
Johnson, Theron S.
Schulze, Matthias B.
Trichopoulou, Antonia
Peppa, Eleni
Vecchia, Carlo La
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Skeie, Guri
Quirós, José Ramón
Rodríguez Barranco, Miguel
Amiano, Pilar
Chirlaque, María Dolores
Ardanaz, Eva
Almquist, Martin
Hennings, Joakim
Vermeulen, Roel
Wareham, Nicholas J.
Tong, Tammy Y. N.
Aune, Dagfinn
Byrnes, Graham
Weiderpass, Elisabete
Scalbert, Augustin
Rinaldi, Sabina
Agudo, Antonio
author_role author
author2 Luján Barroso, Leila
Achaintre, David
Franceschi, Silvia
Kyrø, Cecilie
Overvad, Kim
Tjønneland, Anne
Truong, Thérèse
Lecuyer, Lucie
Boutron-Ruault, Marie-Christine
Katzke, Verena
Johnson, Theron S.
Schulze, Matthias B.
Trichopoulou, Antonia
Peppa, Eleni
Vecchia, Carlo La
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Skeie, Guri
Quirós, José Ramón
Rodríguez Barranco, Miguel
Amiano, Pilar
Chirlaque, María Dolores
Ardanaz, Eva
Almquist, Martin
Hennings, Joakim
Vermeulen, Roel
Wareham, Nicholas J.
Tong, Tammy Y. N.
Aune, Dagfinn
Byrnes, Graham
Weiderpass, Elisabete
Scalbert, Augustin
Rinaldi, Sabina
Agudo, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer
Nutrició
Polifenols
Cancer
Nutrition
Polyphenols
topic Càncer
Nutrició
Polifenols
Cancer
Nutrition
Polyphenols
description Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172181
url https://hdl.handle.net/2445/172181
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1093/ajcn/nqaa277
The American Journal of Clinical Nutrition, 2020
https://doi.org/10.1093/ajcn/nqaa277
dc.rights.none.fl_str_mv (c) Zamora-Ros et al., 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Zamora-Ros et al., 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press (OUP)
publisher.none.fl_str_mv Oxford University Press (OUP)
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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