Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis.

Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sep...

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Detalles Bibliográficos
Autores: Ruiz-Sanchez, Jorge Gabriel, Nunez-Gil, Ivan J, Cuesta, Martin, Rubio, Miguel A, Maroun-Eid, Charbel, Arroyo-Espliguero, Ramon, Romero, Rodolfo, Becerra-Munoz, Victor Manuel, Uribarri, Aitor, Feltes, Gisela, Trabattoni, Daniela, Molina, Maria, Garcia Aguado, Marcos, Pepe, Martino, Cerrato, Enrico, Alfonso, Emilio, Castro Mejia, Alex Fernando, Roubin, Sergio Raposeiras, Buzon, Luis, Bondia, Elvira, Marin, Francisco, Lopez Pais, Javier, Abumayyaleh, Mohammad, D'Ascenzo, Fabrizio, Rondano, Elisa, Huang, Jia, Fernandez-Perez, Cristina, Macaya, Carlos, de Miguel Novoa, Paz, Calle-Pascual, Alfonso L, Estrada Perez, Vicente, Runkle, Isabelle, HOPE COVID-19 investigators
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15216
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15216
Access Level:acceso abierto
Palabra clave:hyponatremia
hypernatremia
COVID-19
SARS-COV2
mortality
sepsis
Descripción
Sumario:Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive therapy (IT) in patients hospitalized with SARS-COV2 pneumonia. This is a retrospective study of the HOPE-COVID-19 registry, with data collected from January 1th through April 31th, 2020. We selected all hospitalized adult patients with RT-PCR-confirmed SARS-COV2 pneumonia and a registered admission serum sodium level (SNa). Patients were classified as hyponatremic (SNa <135 mmol/L), eunatremic (SNa 135-145 mmol/L), or hypernatremic (SNa >145 mmol/L). Multivariable analyses were performed to elucidate independent relationships of admission hyponatremia and hypernatremia, with mortality, sepsis, or IT during hospitalization. Four thousand six hundred sixty-four patients were analyzed, median age 66 (52-77), 58% males. Death occurred in 988 (21.2%) patients, sepsis was diagnosed in 551 (12%) and IT in 838 (18.4%). Hyponatremia was present in 957/4,664 (20.5%) patients, and hypernatremia in 174/4,664 (3.7%). Both hyponatremia and hypernatremia were associated with mortality and sepsis. Only hyponatremia was associated with IT. In conclusion, hyponatremia and hypernatremia at admission are factors independently associated with mortality and sepsis in patients hospitalized with SARS-COV2 pneumonia. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04334291, NCT04334291.

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