Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges

Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although...

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Autores: Bonilla Vidal, Lorena, Esteruelas Navarro, Gerard, Ettcheto Arriola, Miren, Espina García, Marta, García López, María Luisa, Camins Espuny, Antoni, Souto, Eliana B., Cano Fernández, Amanda, Sánchez-López, E. (Elena)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/183043
Acceso en línea:https://hdl.handle.net/2445/183043
Access Level:acceso abierto
Palabra clave:Epilèpsia
Nanopartícules
Malalties neurodegeneratives
Nanotecnologia
Epilepsy
Nanoparticles
Neurodegenerative Diseases
Nanotechnology
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spelling Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challengesBonilla Vidal, LorenaEsteruelas Navarro, GerardEttcheto Arriola, MirenEspina García, MartaGarcía López, María LuisaCamins Espuny, AntoniSouto, Eliana B.Cano Fernández, AmandaSánchez-López, E. (Elena)EpilèpsiaNanopartículesMalalties neurodegenerativesNanotecnologiaEpilepsyNanoparticlesNeurodegenerative DiseasesNanotechnologyEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid-based nanocarriers as novel tools for the management of epilepsy disorders. Keywords: epilepsy; lipid nanoparticles; nanomedicine; nanotechnology; neurodegenerative diseases; polymeric nanoparticles.John Wiley & Sons2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/2445/183043Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/epi4.12567Epilepsia Open, 2021https://doi.org/10.1002/epi4.12567cc-by-nc-nd (c) Bonilla, Lorena et al., 2021https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1830432026-05-29T05:05:01Z
dc.title.none.fl_str_mv Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
title Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
spellingShingle Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
Bonilla Vidal, Lorena
Epilèpsia
Nanopartícules
Malalties neurodegeneratives
Nanotecnologia
Epilepsy
Nanoparticles
Neurodegenerative Diseases
Nanotechnology
title_short Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
title_full Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
title_fullStr Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
title_full_unstemmed Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
title_sort Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
dc.creator.none.fl_str_mv Bonilla Vidal, Lorena
Esteruelas Navarro, Gerard
Ettcheto Arriola, Miren
Espina García, Marta
García López, María Luisa
Camins Espuny, Antoni
Souto, Eliana B.
Cano Fernández, Amanda
Sánchez-López, E. (Elena)
author Bonilla Vidal, Lorena
author_facet Bonilla Vidal, Lorena
Esteruelas Navarro, Gerard
Ettcheto Arriola, Miren
Espina García, Marta
García López, María Luisa
Camins Espuny, Antoni
Souto, Eliana B.
Cano Fernández, Amanda
Sánchez-López, E. (Elena)
author_role author
author2 Esteruelas Navarro, Gerard
Ettcheto Arriola, Miren
Espina García, Marta
García López, María Luisa
Camins Espuny, Antoni
Souto, Eliana B.
Cano Fernández, Amanda
Sánchez-López, E. (Elena)
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epilèpsia
Nanopartícules
Malalties neurodegeneratives
Nanotecnologia
Epilepsy
Nanoparticles
Neurodegenerative Diseases
Nanotechnology
topic Epilèpsia
Nanopartícules
Malalties neurodegeneratives
Nanotecnologia
Epilepsy
Nanoparticles
Neurodegenerative Diseases
Nanotechnology
description Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid-based nanocarriers as novel tools for the management of epilepsy disorders. Keywords: epilepsy; lipid nanoparticles; nanomedicine; nanotechnology; neurodegenerative diseases; polymeric nanoparticles.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183043
url https://hdl.handle.net/2445/183043
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/epi4.12567
Epilepsia Open, 2021
https://doi.org/10.1002/epi4.12567
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Bonilla, Lorena et al., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Bonilla, Lorena et al., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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