Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study

PURPOSE: To define the role of increased fundus autofluorescence (FAF), a surrogate for lipofuscin content, as a risk factor for progression of geographic atrophy (GA). DESIGN: Prospective natural history cohort study, the GAIN (Characterization of geographic atrophy progression in patients with age...

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Autores: Biarnés Pérez, Marc, 1973-, Arias, Luis, Alonso Caballero, Jordi, García, Míriam, Hijano, Míriam, Rodríguez, Anabel, Serrano, Anna, Badal, Josep, Muhtaseb, Hussein, Verdaguer, Paula, Monés, Jordi (Monés Carilla)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/24835
Acceso en línea:http://hdl.handle.net/10230/24835
http://dx.doi.org/10.1016/j.ajo.2015.05.009
Access Level:acceso abierto
Palabra clave:Degeneració macular
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spelling Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN studyBiarnés Pérez, Marc, 1973-Arias, LuisAlonso Caballero, JordiGarcía, MíriamHijano, MíriamRodríguez, AnabelSerrano, AnnaBadal, JosepMuhtaseb, HusseinVerdaguer, PaulaMonés, Jordi (Monés Carilla)Degeneració macularPURPOSE: To define the role of increased fundus autofluorescence (FAF), a surrogate for lipofuscin content, as a risk factor for progression of geographic atrophy (GA). DESIGN: Prospective natural history cohort study, the GAIN (Characterization of geographic atrophy progression in patients with age-related macular degeneration). METHODS: setting: Single-center study conducted in Barcelona, Spain. PATIENTS: After screening of 211 patients, 109 eyes of 82 patients with GA secondary to age-related macular degeneration and a minimum follow-up of 6 months were included. OBSERVATION PROCEDURES: Lipofuscin content was classified independently by 2 masked observers according to FAF patterns described previously. Bivariate, stratified, and multivariable analyses were used to explore the associations between GA growth and independent variables. Mediation analysis was used to evaluate the contribution of FAF patterns to GA progression. MAIN OUTCOME: Progression of GA in mm(2)/year as measured with FAF. RESULTS: Median follow-up was 18 months (range, 6-42). Median GA growth was 1.61 mm(2)/year. FAF, baseline area of atrophy, and time of follow-up were independently associated with GA progression (P < .004). FAF patterns and baseline area of atrophy were strongly associated (P < .0001), suggesting potential confounding. Mediation analysis suggested that most of the effect of FAF patterns on GA growth was actually caused by baseline area of atrophy. CONCLUSIONS: FAF patterns, baseline area of atrophy, and time of follow-up were associated with GA progression. However, FAF patterns seem to be a consequence (not a cause) of enlarging atrophy and their effect on GA progression seems mostly driven by baseline area of atrophy.Elsevier Science201520162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/24835http://dx.doi.org/10.1016/j.ajo.2015.05.009reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésAmerican Journal of Ophthalmology. 2015 Aug;160(2):345-53© 2015 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.ajo.2015.05.009info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/248352026-06-12T07:21:37Z
dc.title.none.fl_str_mv Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
title Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
spellingShingle Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
Biarnés Pérez, Marc, 1973-
Degeneració macular
title_short Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
title_full Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
title_fullStr Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
title_full_unstemmed Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
title_sort Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study
dc.creator.none.fl_str_mv Biarnés Pérez, Marc, 1973-
Arias, Luis
Alonso Caballero, Jordi
García, Míriam
Hijano, Míriam
Rodríguez, Anabel
Serrano, Anna
Badal, Josep
Muhtaseb, Hussein
Verdaguer, Paula
Monés, Jordi (Monés Carilla)
author Biarnés Pérez, Marc, 1973-
author_facet Biarnés Pérez, Marc, 1973-
Arias, Luis
Alonso Caballero, Jordi
García, Míriam
Hijano, Míriam
Rodríguez, Anabel
Serrano, Anna
Badal, Josep
Muhtaseb, Hussein
Verdaguer, Paula
Monés, Jordi (Monés Carilla)
author_role author
author2 Arias, Luis
Alonso Caballero, Jordi
García, Míriam
Hijano, Míriam
Rodríguez, Anabel
Serrano, Anna
Badal, Josep
Muhtaseb, Hussein
Verdaguer, Paula
Monés, Jordi (Monés Carilla)
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Degeneració macular
topic Degeneració macular
description PURPOSE: To define the role of increased fundus autofluorescence (FAF), a surrogate for lipofuscin content, as a risk factor for progression of geographic atrophy (GA). DESIGN: Prospective natural history cohort study, the GAIN (Characterization of geographic atrophy progression in patients with age-related macular degeneration). METHODS: setting: Single-center study conducted in Barcelona, Spain. PATIENTS: After screening of 211 patients, 109 eyes of 82 patients with GA secondary to age-related macular degeneration and a minimum follow-up of 6 months were included. OBSERVATION PROCEDURES: Lipofuscin content was classified independently by 2 masked observers according to FAF patterns described previously. Bivariate, stratified, and multivariable analyses were used to explore the associations between GA growth and independent variables. Mediation analysis was used to evaluate the contribution of FAF patterns to GA progression. MAIN OUTCOME: Progression of GA in mm(2)/year as measured with FAF. RESULTS: Median follow-up was 18 months (range, 6-42). Median GA growth was 1.61 mm(2)/year. FAF, baseline area of atrophy, and time of follow-up were independently associated with GA progression (P < .004). FAF patterns and baseline area of atrophy were strongly associated (P < .0001), suggesting potential confounding. Mediation analysis suggested that most of the effect of FAF patterns on GA growth was actually caused by baseline area of atrophy. CONCLUSIONS: FAF patterns, baseline area of atrophy, and time of follow-up were associated with GA progression. However, FAF patterns seem to be a consequence (not a cause) of enlarging atrophy and their effect on GA progression seems mostly driven by baseline area of atrophy.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/24835
http://dx.doi.org/10.1016/j.ajo.2015.05.009
url http://hdl.handle.net/10230/24835
http://dx.doi.org/10.1016/j.ajo.2015.05.009
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv American Journal of Ophthalmology. 2015 Aug;160(2):345-53
dc.rights.none.fl_str_mv © 2015 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.ajo.2015.05.009
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2015 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.ajo.2015.05.009
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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