Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report

Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ib...

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Autores: Shabestari, Maziar, Eriksen, Erik Fink, Paschalis, Eleftherios P., Roschger, Paul, Gamsjaeger, Sonja, Klaushofer, Klaus, Berzlanovich, Andrea, Nogués Solán, Xavier, Puig Verdié, Luís, Díez Pérez, Adolfo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/33327
Acceso en línea:http://hdl.handle.net/10230/33327
http://dx.doi.org/10.1016/j.bonr.2017.02.006
Access Level:acceso abierto
Palabra clave:Fractures
Atypical femoral fracture
Pyrophosphate
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spelling Presence of pyrophosphate in bone from an atypical femoral fracture site: A case reportShabestari, MaziarEriksen, Erik FinkPaschalis, Eleftherios P.Roschger, PaulGamsjaeger, SonjaKlaushofer, KlausBerzlanovich, AndreaNogués Solán, XavierPuig Verdié, LuísDíez Pérez, AdolfoFracturesAtypical femoral fracturePyrophosphateLong-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis. The results indicate ongoing osteoclastic resorption, but also several abnormalities: 1) an altered arrangement of osteons; 2) impaired mineralization; 3) the presence of pyrophosphate, which might contribute to the impaired mineralization evident in the present case. Taken together, these changes may contribute to the focally reduced bone strength of this patient.Elsevier201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33327http://dx.doi.org/10.1016/j.bonr.2017.02.006reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBone Reports. 2017 Mar 2;6:81-6Copyright © 2017 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/333272026-05-29T05:05:01Z
dc.title.none.fl_str_mv Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
title Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
spellingShingle Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
Shabestari, Maziar
Fractures
Atypical femoral fracture
Pyrophosphate
title_short Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
title_full Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
title_fullStr Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
title_full_unstemmed Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
title_sort Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
dc.creator.none.fl_str_mv Shabestari, Maziar
Eriksen, Erik Fink
Paschalis, Eleftherios P.
Roschger, Paul
Gamsjaeger, Sonja
Klaushofer, Klaus
Berzlanovich, Andrea
Nogués Solán, Xavier
Puig Verdié, Luís
Díez Pérez, Adolfo
author Shabestari, Maziar
author_facet Shabestari, Maziar
Eriksen, Erik Fink
Paschalis, Eleftherios P.
Roschger, Paul
Gamsjaeger, Sonja
Klaushofer, Klaus
Berzlanovich, Andrea
Nogués Solán, Xavier
Puig Verdié, Luís
Díez Pérez, Adolfo
author_role author
author2 Eriksen, Erik Fink
Paschalis, Eleftherios P.
Roschger, Paul
Gamsjaeger, Sonja
Klaushofer, Klaus
Berzlanovich, Andrea
Nogués Solán, Xavier
Puig Verdié, Luís
Díez Pérez, Adolfo
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fractures
Atypical femoral fracture
Pyrophosphate
topic Fractures
Atypical femoral fracture
Pyrophosphate
description Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis. The results indicate ongoing osteoclastic resorption, but also several abnormalities: 1) an altered arrangement of osteons; 2) impaired mineralization; 3) the presence of pyrophosphate, which might contribute to the impaired mineralization evident in the present case. Taken together, these changes may contribute to the focally reduced bone strength of this patient.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/33327
http://dx.doi.org/10.1016/j.bonr.2017.02.006
url http://hdl.handle.net/10230/33327
http://dx.doi.org/10.1016/j.bonr.2017.02.006
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bone Reports. 2017 Mar 2;6:81-6
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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