Deciphering the oxidative stress response in Candida albicans

Candida species are the leading cause of invasive fungal infections, with Candida albicans being the most common one. Consequently, the World Health Organization has included C. albicans in its fungal priority pathogens list. Following infection, phagocytes (mostly macrophages) initiate a respirator...

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Detalles Bibliográficos
Autores: Arribas Antón, Víctor, Molero Martín-Portugués, María Gloria, Gil , Concha
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/126233
Acceso en línea:https://hdl.handle.net/20.500.14352/126233
Access Level:acceso abierto
Palabra clave:579.61
Candida albicans
oxidative stress
antifungal target
proteomics
mutants
Ciencias Biomédicas
Microbiología (Farmacia)
3201.03 Microbiología Clínica
3302.03 Microbiología Industrial
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oai_identifier_str oai:docta.ucm.es:20.500.14352/126233
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spelling Deciphering the oxidative stress response in Candida albicansArribas Antón, VíctorMolero Martín-Portugués, María GloriaGil , Concha579.61Candida albicansoxidative stressantifungal targetproteomicsmutantsCiencias BiomédicasMicrobiología (Farmacia)3201.03 Microbiología Clínica3302.03 Microbiología IndustrialCandida species are the leading cause of invasive fungal infections, with Candida albicans being the most common one. Consequently, the World Health Organization has included C. albicans in its fungal priority pathogens list. Following infection, phagocytes (mostly macrophages) initiate a respiratory burst, producing oxidant compounds, such as hydrogen peroxide. In response, C. albicans activates a robust oxidative stress response to catalyze the oxidant molecules produced by the immune system and counteract their oxidative effects within the cell. The oxidative stress response of C. albicans implies proteomic changes, both in abundance and in post-translational modifications, that are not fully described yet. Proteins with immediate antioxidant properties, the MAPK signaling pathways, and transcription factors are involved in the response. In this review, we discuss the role of these factors and the interactions among them in C. albicans. Many of these mechanisms act as virulence traits that favor the invasive candidiasis and can be used as potential targets for antifungal drugs.ElsevierUniversidad Complutense de Madrid20252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/126233reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124062NB-I00 INTERACCION CANDIDA ALBICANS- HOSPEDADOR: VESICULAS EXTRACELULARES, ESTRES OXIDATIVO Y RESPUESTA INMUNITARIA. RELACION ENTRE MICROBIOTA INTESTINAL Y SEPSIS.open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1262332026-06-02T12:44:21Z
dc.title.none.fl_str_mv Deciphering the oxidative stress response in Candida albicans
title Deciphering the oxidative stress response in Candida albicans
spellingShingle Deciphering the oxidative stress response in Candida albicans
Arribas Antón, Víctor
579.61
Candida albicans
oxidative stress
antifungal target
proteomics
mutants
Ciencias Biomédicas
Microbiología (Farmacia)
3201.03 Microbiología Clínica
3302.03 Microbiología Industrial
title_short Deciphering the oxidative stress response in Candida albicans
title_full Deciphering the oxidative stress response in Candida albicans
title_fullStr Deciphering the oxidative stress response in Candida albicans
title_full_unstemmed Deciphering the oxidative stress response in Candida albicans
title_sort Deciphering the oxidative stress response in Candida albicans
dc.creator.none.fl_str_mv Arribas Antón, Víctor
Molero Martín-Portugués, María Gloria
Gil , Concha
author Arribas Antón, Víctor
author_facet Arribas Antón, Víctor
Molero Martín-Portugués, María Gloria
Gil , Concha
author_role author
author2 Molero Martín-Portugués, María Gloria
Gil , Concha
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579.61
Candida albicans
oxidative stress
antifungal target
proteomics
mutants
Ciencias Biomédicas
Microbiología (Farmacia)
3201.03 Microbiología Clínica
3302.03 Microbiología Industrial
topic 579.61
Candida albicans
oxidative stress
antifungal target
proteomics
mutants
Ciencias Biomédicas
Microbiología (Farmacia)
3201.03 Microbiología Clínica
3302.03 Microbiología Industrial
description Candida species are the leading cause of invasive fungal infections, with Candida albicans being the most common one. Consequently, the World Health Organization has included C. albicans in its fungal priority pathogens list. Following infection, phagocytes (mostly macrophages) initiate a respiratory burst, producing oxidant compounds, such as hydrogen peroxide. In response, C. albicans activates a robust oxidative stress response to catalyze the oxidant molecules produced by the immune system and counteract their oxidative effects within the cell. The oxidative stress response of C. albicans implies proteomic changes, both in abundance and in post-translational modifications, that are not fully described yet. Proteins with immediate antioxidant properties, the MAPK signaling pathways, and transcription factors are involved in the response. In this review, we discuss the role of these factors and the interactions among them in C. albicans. Many of these mechanisms act as virulence traits that favor the invasive candidiasis and can be used as potential targets for antifungal drugs.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/126233
url https://hdl.handle.net/20.500.14352/126233
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124062NB-I00 INTERACCION CANDIDA ALBICANS- HOSPEDADOR: VESICULAS EXTRACELULARES, ESTRES OXIDATIVO Y RESPUESTA INMUNITARIA. RELACION ENTRE MICROBIOTA INTESTINAL Y SEPSIS.
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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