Simulating evolution in asexual populations with epistasis
I show how to use OncoSimulR, software for forward-time genetic simulations, to simulate evolution of asexual populations in the presence of epistatic interactions. This chapter emphasizes the specification of fitness and epistasis, both directly (i.e., specifying the effects of individual mutations...
| Autor: | |
|---|---|
| Tipo de recurso: | capítulo de libro |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/690422 |
| Acceso en línea: | http://hdl.handle.net/10486/690422 https://dx.doi.org/10.1007/978-1-0716-0947-7_9 |
| Access Level: | acceso abierto |
| Palabra clave: | simulation epistasis fitness landscape evolution mutation fitness Biología y Biomedicina / Biología |
| Sumario: | I show how to use OncoSimulR, software for forward-time genetic simulations, to simulate evolution of asexual populations in the presence of epistatic interactions. This chapter emphasizes the specification of fitness and epistasis, both directly (i.e., specifying the effects of individual mutations and their epistatic interactions) and indirectly (using models for random fitness landscapes) |
|---|