Control of cell-cell forces and collective cell dynamics by the intercellular adhesome

Dynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that resist and transmit forces at cell-cell junctions remains unclear, and how the...

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Autores: Bazellières, Elsa, Conte, Vito, Elosegui Artola, Alberto, Serra Picamal, Xavier, Bintanel Morcillo, María, Roca-Cusachs Soulere, Pere, Muñoz, José J., Sales i Pardo, Marta, Guimerà Manrique, Roger, Trepat Guixer, Xavier
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/128141
Acceso en línea:https://hdl.handle.net/2445/128141
Access Level:acceso abierto
Palabra clave:Cèl·lules epitelials
Càncer
Epithelial cells
Cancer
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spelling Control of cell-cell forces and collective cell dynamics by the intercellular adhesomeBazellières, ElsaConte, VitoElosegui Artola, AlbertoSerra Picamal, XavierBintanel Morcillo, MaríaRoca-Cusachs Soulere, PereMuñoz, José J.Sales i Pardo, MartaGuimerà Manrique, RogerTrepat Guixer, XavierCèl·lules epitelialsCàncerEpithelial cellsCancerDynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that resist and transmit forces at cell-cell junctions remains unclear, and how these proteins control tissue dynamics is largely unknown. Here we provide a systematic study of the interplay between cell-cell adhesion proteins, intercellular forces and epithelial tissue dynamics. We show that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes. These phenotypes are controlled by different molecular modules and characterized by distinct relationships between cellular kinematics and intercellular forces. We show that these forces and their rates can be predicted by the concentrations of cadherins and catenins. Unexpectedly, we identified different mechanical roles for P-cadherin and E-cadherin; whereas P-cadherin predicts levels of intercellular force, E-cadherin predicts the rate at which intercellular force builds up.Nature Publishing Group2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/128141Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1038/ncb3135Nature Cell Biology, 2015, vol. 17, num. 4, p. 409-420https://doi.org/10.1038/ncb3135info:eu-repo/grantAgreement/EC/FP7/242993info:eu-repo/grantAgreement/EC/FP7/277166info:eu-repo/grantAgreement/EC/FP7/303848info:eu-repo/grantAgreement/EC/FP7/268342info:eu-repo/grantAgreement/EC/FP7/616480(c) Bazellières, Elsa et al., 2015info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1281412026-05-27T06:46:51Z
dc.title.none.fl_str_mv Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
title Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
spellingShingle Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
Bazellières, Elsa
Cèl·lules epitelials
Càncer
Epithelial cells
Cancer
title_short Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
title_full Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
title_fullStr Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
title_full_unstemmed Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
title_sort Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
dc.creator.none.fl_str_mv Bazellières, Elsa
Conte, Vito
Elosegui Artola, Alberto
Serra Picamal, Xavier
Bintanel Morcillo, María
Roca-Cusachs Soulere, Pere
Muñoz, José J.
Sales i Pardo, Marta
Guimerà Manrique, Roger
Trepat Guixer, Xavier
author Bazellières, Elsa
author_facet Bazellières, Elsa
Conte, Vito
Elosegui Artola, Alberto
Serra Picamal, Xavier
Bintanel Morcillo, María
Roca-Cusachs Soulere, Pere
Muñoz, José J.
Sales i Pardo, Marta
Guimerà Manrique, Roger
Trepat Guixer, Xavier
author_role author
author2 Conte, Vito
Elosegui Artola, Alberto
Serra Picamal, Xavier
Bintanel Morcillo, María
Roca-Cusachs Soulere, Pere
Muñoz, José J.
Sales i Pardo, Marta
Guimerà Manrique, Roger
Trepat Guixer, Xavier
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules epitelials
Càncer
Epithelial cells
Cancer
topic Cèl·lules epitelials
Càncer
Epithelial cells
Cancer
description Dynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that resist and transmit forces at cell-cell junctions remains unclear, and how these proteins control tissue dynamics is largely unknown. Here we provide a systematic study of the interplay between cell-cell adhesion proteins, intercellular forces and epithelial tissue dynamics. We show that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes. These phenotypes are controlled by different molecular modules and characterized by distinct relationships between cellular kinematics and intercellular forces. We show that these forces and their rates can be predicted by the concentrations of cadherins and catenins. Unexpectedly, we identified different mechanical roles for P-cadherin and E-cadherin; whereas P-cadherin predicts levels of intercellular force, E-cadherin predicts the rate at which intercellular force builds up.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/128141
url https://hdl.handle.net/2445/128141
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1038/ncb3135
Nature Cell Biology, 2015, vol. 17, num. 4, p. 409-420
https://doi.org/10.1038/ncb3135
info:eu-repo/grantAgreement/EC/FP7/242993
info:eu-repo/grantAgreement/EC/FP7/277166
info:eu-repo/grantAgreement/EC/FP7/303848
info:eu-repo/grantAgreement/EC/FP7/268342
info:eu-repo/grantAgreement/EC/FP7/616480
dc.rights.none.fl_str_mv (c) Bazellières, Elsa et al., 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Bazellières, Elsa et al., 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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