Matrix metalloproteinase 10 contributes to choroidal neovascularisation

González-Zamora, J. (Jorge)|||/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17; Hernandez, M. (María)|||/items/64ef42cb-3438-4cd6-b8db-8a01244368da; Recalde-Maestre, S. (Sergio)|||/items/1f021661-e027-480f-bd57-ce3bfb8e5a0e; Bezunartea, J. (Jaione)|||/items/8f33ef1e-c03e-4e9e-a141-06c02e0f39dd; Montoliu-Antón, A. (Ana)|||/items/d2c15d21-50de-4984-ad3c-3703f95a1f38; Bilbao-Malavé, V. (Valentina)|||/items/024d213a-2062-473e-8ce1-949c6e2ad785; Orbe-Lopategui, J. (Josune)|||/items/033ea7ef-1eff-418a-9fc4-1e2d3498d726; Rodríguez, José|||/items/cbc5e11a-4053-4301-9fc8-e97d2a22b9d3; Llorente-González, S. (Sara)|||/items/9344a7cf-6e05-41bd-a374-bfbd54ea1c47; Fernandez-Robredo, P. (Patricia)|||/items/cebb4451-3415-44cf-811a-c5ae0b139604; Garcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836

Matrix metalloproteinase 10 contributes to choroidal neovascularisation

Age-related macular degeneration (AMD) is currently the main cause of severe visual loss among older adults in developed countries. The pathophysiology has not been clarified, but oxidative stress is believed to play a major role. Matrix metalloproteinases (MMP) may play a prominent role in several...

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Authors:	González-Zamora, J. (Jorge)\|\|\|/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17, Hernandez, M. (María)\|\|\|/items/64ef42cb-3438-4cd6-b8db-8a01244368da, Recalde-Maestre, S. (Sergio)\|\|\|/items/1f021661-e027-480f-bd57-ce3bfb8e5a0e, Bezunartea, J. (Jaione)\|\|\|/items/8f33ef1e-c03e-4e9e-a141-06c02e0f39dd, Montoliu-Antón, A. (Ana)\|\|\|/items/d2c15d21-50de-4984-ad3c-3703f95a1f38, Bilbao-Malavé, V. (Valentina)\|\|\|/items/024d213a-2062-473e-8ce1-949c6e2ad785, Orbe-Lopategui, J. (Josune)\|\|\|/items/033ea7ef-1eff-418a-9fc4-1e2d3498d726, Rodríguez, José\|\|\|/items/cbc5e11a-4053-4301-9fc8-e97d2a22b9d3, Llorente-González, S. (Sara)\|\|\|/items/9344a7cf-6e05-41bd-a374-bfbd54ea1c47, Fernandez-Robredo, P. (Patricia)\|\|\|/items/cebb4451-3415-44cf-811a-c5ae0b139604, Garcia-Layana, A. (Alfredo)\|\|\|/items/631fff44-be4e-42e5-ad3a-8f0f10305836
Format:	article
Publication Date:	2022
Country:	España
Institution:	Universidad de Navarra
Repository:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:	English
OAI Identifier:	oai:dadun.unav.edu:10171/119712
Online Access:	https://hdl.handle.net/10171/119712
Access Level:	Open access
Keyword:	Age-related macular degeneration Angiogenesis Choroidal neovascularisation Matrix metalloproteinase Oxidative stress

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spelling	Matrix metalloproteinase 10 contributes to choroidal neovascularisationGonzález-Zamora, J. (Jorge)\|\|\|/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17Hernandez, M. (María)\|\|\|/items/64ef42cb-3438-4cd6-b8db-8a01244368daRecalde-Maestre, S. (Sergio)\|\|\|/items/1f021661-e027-480f-bd57-ce3bfb8e5a0eBezunartea, J. (Jaione)\|\|\|/items/8f33ef1e-c03e-4e9e-a141-06c02e0f39ddMontoliu-Antón, A. (Ana)\|\|\|/items/d2c15d21-50de-4984-ad3c-3703f95a1f38Bilbao-Malavé, V. (Valentina)\|\|\|/items/024d213a-2062-473e-8ce1-949c6e2ad785Orbe-Lopategui, J. (Josune)\|\|\|/items/033ea7ef-1eff-418a-9fc4-1e2d3498d726Rodríguez, José\|\|\|/items/cbc5e11a-4053-4301-9fc8-e97d2a22b9d3Llorente-González, S. (Sara)\|\|\|/items/9344a7cf-6e05-41bd-a374-bfbd54ea1c47Fernandez-Robredo, P. (Patricia)\|\|\|/items/cebb4451-3415-44cf-811a-c5ae0b139604Garcia-Layana, A. (Alfredo)\|\|\|/items/631fff44-be4e-42e5-ad3a-8f0f10305836Age-related macular degenerationAngiogenesisChoroidal neovascularisationMatrix metalloproteinaseOxidative stressAge-related macular degeneration (AMD) is currently the main cause of severe visual loss among older adults in developed countries. The pathophysiology has not been clarified, but oxidative stress is believed to play a major role. Matrix metalloproteinases (MMP) may play a prominent role in several steps of the pathophysiology of AMD, especially in its neovascular form; therefore, there is of great interest in understanding their role in choroidal neovascularisation. This study aimed to elucidate the role of MMP10 in the development of choroidal neovascularisation (CNV). We have demonstrated that MMP10 was expressed by retinal pigment epithelium cells and endothelial cells of the neovascular membrane, in cell culture, mouse and human retina. MMP10 expression and activity increased under oxidative stress conditions in ARPE-19 cells. MMP10-/- mice developed smaller laser-induced areas of CNV. Furthermore, to exclude a systemic MMP10 imbalance in these patients, plasma MMP10 concentrations were assessed in an age- and sex-matched sample of 52 control patients and 52 patients with neovascular AMD and no significant differences were found between the groups, demonstrating that MMP10 induction is a local phenomenon. Our findings suggest that MMP10 participates in the development of choroidal neovascularisation and promotes MMP10 as a possible new therapeutic target.MDPIDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/119712reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1197122026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
title	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
spellingShingle	Matrix metalloproteinase 10 contributes to choroidal neovascularisation González-Zamora, J. (Jorge)\|\|\|/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17 Age-related macular degeneration Angiogenesis Choroidal neovascularisation Matrix metalloproteinase Oxidative stress
title_short	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
title_full	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
title_fullStr	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
title_full_unstemmed	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
title_sort	Matrix metalloproteinase 10 contributes to choroidal neovascularisation
dc.creator.none.fl_str_mv	González-Zamora, J. (Jorge)\|\|\|/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17 Hernandez, M. (María)\|\|\|/items/64ef42cb-3438-4cd6-b8db-8a01244368da Recalde-Maestre, S. (Sergio)\|\|\|/items/1f021661-e027-480f-bd57-ce3bfb8e5a0e Bezunartea, J. (Jaione)\|\|\|/items/8f33ef1e-c03e-4e9e-a141-06c02e0f39dd Montoliu-Antón, A. (Ana)\|\|\|/items/d2c15d21-50de-4984-ad3c-3703f95a1f38 Bilbao-Malavé, V. (Valentina)\|\|\|/items/024d213a-2062-473e-8ce1-949c6e2ad785 Orbe-Lopategui, J. (Josune)\|\|\|/items/033ea7ef-1eff-418a-9fc4-1e2d3498d726 Rodríguez, José\|\|\|/items/cbc5e11a-4053-4301-9fc8-e97d2a22b9d3 Llorente-González, S. (Sara)\|\|\|/items/9344a7cf-6e05-41bd-a374-bfbd54ea1c47 Fernandez-Robredo, P. (Patricia)\|\|\|/items/cebb4451-3415-44cf-811a-c5ae0b139604 Garcia-Layana, A. (Alfredo)\|\|\|/items/631fff44-be4e-42e5-ad3a-8f0f10305836
author	González-Zamora, J. (Jorge)\|\|\|/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17
author_facet	González-Zamora, J. (Jorge)\|\|\|/items/8ac4ee56-6070-49a3-b32f-5d3e8f9eef17 Hernandez, M. (María)\|\|\|/items/64ef42cb-3438-4cd6-b8db-8a01244368da Recalde-Maestre, S. (Sergio)\|\|\|/items/1f021661-e027-480f-bd57-ce3bfb8e5a0e Bezunartea, J. (Jaione)\|\|\|/items/8f33ef1e-c03e-4e9e-a141-06c02e0f39dd Montoliu-Antón, A. (Ana)\|\|\|/items/d2c15d21-50de-4984-ad3c-3703f95a1f38 Bilbao-Malavé, V. (Valentina)\|\|\|/items/024d213a-2062-473e-8ce1-949c6e2ad785 Orbe-Lopategui, J. (Josune)\|\|\|/items/033ea7ef-1eff-418a-9fc4-1e2d3498d726 Rodríguez, José\|\|\|/items/cbc5e11a-4053-4301-9fc8-e97d2a22b9d3 Llorente-González, S. (Sara)\|\|\|/items/9344a7cf-6e05-41bd-a374-bfbd54ea1c47 Fernandez-Robredo, P. (Patricia)\|\|\|/items/cebb4451-3415-44cf-811a-c5ae0b139604 Garcia-Layana, A. (Alfredo)\|\|\|/items/631fff44-be4e-42e5-ad3a-8f0f10305836
author_role	author
author2	Hernandez, M. (María)\|\|\|/items/64ef42cb-3438-4cd6-b8db-8a01244368da Recalde-Maestre, S. (Sergio)\|\|\|/items/1f021661-e027-480f-bd57-ce3bfb8e5a0e Bezunartea, J. (Jaione)\|\|\|/items/8f33ef1e-c03e-4e9e-a141-06c02e0f39dd Montoliu-Antón, A. (Ana)\|\|\|/items/d2c15d21-50de-4984-ad3c-3703f95a1f38 Bilbao-Malavé, V. (Valentina)\|\|\|/items/024d213a-2062-473e-8ce1-949c6e2ad785 Orbe-Lopategui, J. (Josune)\|\|\|/items/033ea7ef-1eff-418a-9fc4-1e2d3498d726 Rodríguez, José\|\|\|/items/cbc5e11a-4053-4301-9fc8-e97d2a22b9d3 Llorente-González, S. (Sara)\|\|\|/items/9344a7cf-6e05-41bd-a374-bfbd54ea1c47 Fernandez-Robredo, P. (Patricia)\|\|\|/items/cebb4451-3415-44cf-811a-c5ae0b139604 Garcia-Layana, A. (Alfredo)\|\|\|/items/631fff44-be4e-42e5-ad3a-8f0f10305836
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Age-related macular degeneration Angiogenesis Choroidal neovascularisation Matrix metalloproteinase Oxidative stress
topic	Age-related macular degeneration Angiogenesis Choroidal neovascularisation Matrix metalloproteinase Oxidative stress
description	Age-related macular degeneration (AMD) is currently the main cause of severe visual loss among older adults in developed countries. The pathophysiology has not been clarified, but oxidative stress is believed to play a major role. Matrix metalloproteinases (MMP) may play a prominent role in several steps of the pathophysiology of AMD, especially in its neovascular form; therefore, there is of great interest in understanding their role in choroidal neovascularisation. This study aimed to elucidate the role of MMP10 in the development of choroidal neovascularisation (CNV). We have demonstrated that MMP10 was expressed by retinal pigment epithelium cells and endothelial cells of the neovascular membrane, in cell culture, mouse and human retina. MMP10 expression and activity increased under oxidative stress conditions in ARPE-19 cells. MMP10-/- mice developed smaller laser-induced areas of CNV. Furthermore, to exclude a systemic MMP10 imbalance in these patients, plasma MMP10 concentrations were assessed in an age- and sex-matched sample of 52 control patients and 52 patients with neovascular AMD and no significant differences were found between the groups, demonstrating that MMP10 induction is a local phenomenon. Our findings suggest that MMP10 participates in the development of choroidal neovascularisation and promotes MMP10 as a possible new therapeutic target.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/119712
url	https://hdl.handle.net/10171/119712
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,198674

Matrix metalloproteinase 10 contributes to choroidal neovascularisation

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