ALBIRA: A small animal PET/SPECT/CT imaging system
Purpose: The authors have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray subsystems are based on monolithic crystals coupled to multianode photomultiplier tubes (MA-PMTs), while computed tomography (CT) comprises a commercially available microfocus x-ray tube and a...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/46182 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/46182 |
| Access Level: | acceso abierto |
| Palabra clave: | Nuclear medicine Radionuclide imaging Small animal imaging Integrated PET/SPECT/CT scanner MATEMATICA APLICADA |
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España |
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| dc.title.none.fl_str_mv |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| title |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| spellingShingle |
ALBIRA: A small animal PET/SPECT/CT imaging system Sánchez Martínez, Filomeno Nuclear medicine Radionuclide imaging Small animal imaging Integrated PET/SPECT/CT scanner MATEMATICA APLICADA |
| title_short |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| title_full |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| title_fullStr |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| title_full_unstemmed |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| title_sort |
ALBIRA: A small animal PET/SPECT/CT imaging system |
| dc.creator.none.fl_str_mv |
Sánchez Martínez, Filomeno Orero Palomares, Abel Soriano Asensi, Antonio Correcher Salvador, Carlos Conde Castellanos, Pablo Eloy González Martínez, Antonio Javier Hernández Hernández, Liczandro Moliner Martínez, Laura Vidal San Sebastián, Luis Fernando Chapman, S.E. Rodríguez-Álvarez, M.J.|||0000-0001-8333-8792 Benlloch Baviera, Jose María|||0000-0001-6073-1436 Leevy, W.M. |
| author |
Sánchez Martínez, Filomeno |
| author_facet |
Sánchez Martínez, Filomeno Orero Palomares, Abel Soriano Asensi, Antonio Correcher Salvador, Carlos Conde Castellanos, Pablo Eloy González Martínez, Antonio Javier Hernández Hernández, Liczandro Moliner Martínez, Laura Vidal San Sebastián, Luis Fernando Chapman, S.E. Rodríguez-Álvarez, M.J.|||0000-0001-8333-8792 Benlloch Baviera, Jose María|||0000-0001-6073-1436 Leevy, W.M. |
| author_role |
author |
| author2 |
Orero Palomares, Abel Soriano Asensi, Antonio Correcher Salvador, Carlos Conde Castellanos, Pablo Eloy González Martínez, Antonio Javier Hernández Hernández, Liczandro Moliner Martínez, Laura Vidal San Sebastián, Luis Fernando Chapman, S.E. Rodríguez-Álvarez, M.J.|||0000-0001-8333-8792 Benlloch Baviera, Jose María|||0000-0001-6073-1436 Leevy, W.M. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Matemática Aplicada Escuela Técnica Superior de Ingeniería Informática Instituto de Instrumentación para Imagen Molecular Ministerio de Ciencia e Innovación Generalitat Valenciana Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
Nuclear medicine Radionuclide imaging Small animal imaging Integrated PET/SPECT/CT scanner MATEMATICA APLICADA |
| topic |
Nuclear medicine Radionuclide imaging Small animal imaging Integrated PET/SPECT/CT scanner MATEMATICA APLICADA |
| description |
Purpose: The authors have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray subsystems are based on monolithic crystals coupled to multianode photomultiplier tubes (MA-PMTs), while computed tomography (CT) comprises a commercially available microfocus x-ray tube and a CsI scintillator 2D pixelated flat panel x-ray detector. In this study the authors will report on the design and performance evaluation of the multimodal system. Methods: X-ray transmission measurements are performed based on cone-beam geometry. Individual projections were acquired by rotating the x-ray tube and the 2D flat panel detector, thus making possible a transaxial field of view (FOV) of roughly 80 mm in diameter and an axial FOV of 65 mm for the CT system. The single photon emission computed tomography (SPECT) component has a dual head detector geometry mounted on a rotating gantry. The distance between the SPECT module detectors can be varied in order to optimize specific user requirements, including variable FOV. The positron emission tomography (PET) system is made up of eight compact modules forming an octagon with an axial FOV of 40 mm and a transaxial FOV of 80 mm in diameter. The main CT image quality parameters (spatial resolution and uniformity) have been determined. In the case of the SPECT, the tomographic spatial resolution and system sensitivity have been evaluated with a99mTc solution using single-pinhole and multi-pinhole collimators. PET and SPECT images were reconstructed using three-dimensional (3D) maximum likelihood and ordered subset expectation maximization (MLEM and OSEM) algorithms developed by the authors, whereas the CT images were obtained using a 3D based FBP algorithm. Results: CT spatial resolution was 85μm while a uniformity of 2.7% was obtained for a water filled phantom at 45 kV. The SPECT spatial resolution was better than 0.8 mm measured with a Derenzo-like phantom for a FOV of 20 mm using a 1-mm pinhole aperture collimator. The full width at half-maximum PET radial spatial resolution at the center of the field of view was 1.55 mm. The SPECT system sensitivity for a FOV of 20 mm and 15% energy window was 700 cps/MBq (7.8 × 10−2%) using a multi-pinhole equipped with five apertures 1 mm in diameter, whereas the PET absolute sensitivity was 2% for a 350–650 keV energy window and a 5 ns timing window. Several animal images are also presented. Conclusions: The new small animal PET/SPECT/CT proposed here exhibits high performance, producing high-quality images suitable for studies with small animals. Monolithic design for PET and SPECT scintillator crystals reduces cost and complexity without significant performance degradation. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2013-05-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/46182 |
| url |
https://riunet.upv.es/handle/10251/46182 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FIS2010-21216-C02-01 DESARROLLO DEL DETECTOR PET%2FRM PARA DIAGNOSTICO DE ENFERMEDADES NEURODEGENERATIVAS. Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO08%2F2008%2F114 Desarrollo de tecnología PET%2FRM para estudio cerebro en humanos |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Association of Physicists in Medicine: Medical Physics |
| publisher.none.fl_str_mv |
American Association of Physicists in Medicine: Medical Physics |
| dc.source.none.fl_str_mv |
reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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Universitat Politècnica de València (UPV) |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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1869418733668139008 |
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ALBIRA: A small animal PET/SPECT/CT imaging systemSánchez Martínez, FilomenoOrero Palomares, AbelSoriano Asensi, AntonioCorrecher Salvador, CarlosConde Castellanos, Pablo EloyGonzález Martínez, Antonio JavierHernández Hernández, LiczandroMoliner Martínez, LauraVidal San Sebastián, Luis FernandoChapman, S.E.Rodríguez-Álvarez, M.J.|||0000-0001-8333-8792Benlloch Baviera, Jose María|||0000-0001-6073-1436Leevy, W.M.Nuclear medicineRadionuclide imagingSmall animal imagingIntegrated PET/SPECT/CT scannerMATEMATICA APLICADAPurpose: The authors have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray subsystems are based on monolithic crystals coupled to multianode photomultiplier tubes (MA-PMTs), while computed tomography (CT) comprises a commercially available microfocus x-ray tube and a CsI scintillator 2D pixelated flat panel x-ray detector. In this study the authors will report on the design and performance evaluation of the multimodal system. Methods: X-ray transmission measurements are performed based on cone-beam geometry. Individual projections were acquired by rotating the x-ray tube and the 2D flat panel detector, thus making possible a transaxial field of view (FOV) of roughly 80 mm in diameter and an axial FOV of 65 mm for the CT system. The single photon emission computed tomography (SPECT) component has a dual head detector geometry mounted on a rotating gantry. The distance between the SPECT module detectors can be varied in order to optimize specific user requirements, including variable FOV. The positron emission tomography (PET) system is made up of eight compact modules forming an octagon with an axial FOV of 40 mm and a transaxial FOV of 80 mm in diameter. The main CT image quality parameters (spatial resolution and uniformity) have been determined. In the case of the SPECT, the tomographic spatial resolution and system sensitivity have been evaluated with a99mTc solution using single-pinhole and multi-pinhole collimators. PET and SPECT images were reconstructed using three-dimensional (3D) maximum likelihood and ordered subset expectation maximization (MLEM and OSEM) algorithms developed by the authors, whereas the CT images were obtained using a 3D based FBP algorithm. Results: CT spatial resolution was 85μm while a uniformity of 2.7% was obtained for a water filled phantom at 45 kV. The SPECT spatial resolution was better than 0.8 mm measured with a Derenzo-like phantom for a FOV of 20 mm using a 1-mm pinhole aperture collimator. The full width at half-maximum PET radial spatial resolution at the center of the field of view was 1.55 mm. The SPECT system sensitivity for a FOV of 20 mm and 15% energy window was 700 cps/MBq (7.8 × 10−2%) using a multi-pinhole equipped with five apertures 1 mm in diameter, whereas the PET absolute sensitivity was 2% for a 350–650 keV energy window and a 5 ns timing window. Several animal images are also presented. Conclusions: The new small animal PET/SPECT/CT proposed here exhibits high performance, producing high-quality images suitable for studies with small animals. Monolithic design for PET and SPECT scintillator crystals reduces cost and complexity without significant performance degradation.This study was supported by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant No. FIS2010-21216-CO2-01 and Valencian Local Government under Grant PROMETEO 2008/114. The authors also thank Brennan Holt for checking and correcting the text.American Association of Physicists in Medicine: Medical PhysicsDepartamento de Matemática AplicadaEscuela Técnica Superior de Ingeniería InformáticaInstituto de Instrumentación para Imagen MolecularMinisterio de Ciencia e InnovaciónGeneralitat ValencianaRepositorio Institucional de la Universitat Politècnica de València Riunet20132013-05-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/46182reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FIS2010-21216-C02-01 DESARROLLO DEL DETECTOR PET%2FRM PARA DIAGNOSTICO DE ENFERMEDADES NEURODEGENERATIVAS.Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO08%2F2008%2F114 Desarrollo de tecnología PET%2FRM para estudio cerebro en humanosopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/461822026-06-13T07:49:27Z |
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15.300719 |