Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study

Patients with advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have impaired nutritional and physical performance due to the cancer pathophysiology and its treatment. The NUTRIGETNE study sought to characterize the nutritional status of patients with advanced GEP-NENs in Spain. Th...

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Autores: Del Olmo García, Maribel, Hernandez Rienda, Lorena, Garcia Carbonero, Rocio, Hernando, Jorge, Custodio, Ana, Anton Pascual, Beatriz, Gomez, Marta, Milla, Samara Palma, Suarez, Lorena, Bellver, Marta, Alonso, Vicente, Serrano, Raquel, Valdés, Nuria, Melian, Marcos, Febrero, Beatriz, Sampedro Nuñez, Miguel Antonio, Biarnes, Josefina, Díaz-Pérez, José Ángel, Molina-Cerrillo, Javier, López López, Carlos|||0000-0002-8901-741X
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/36663
Acceso en línea:https://hdl.handle.net/10902/36663
Access Level:acceso abierto
Palabra clave:Nutritional status
Malnutrition
Sarcopenia
Neuroendocrine neoplasms
Gastroenteropancreatic
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spelling Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) studyDel Olmo García, MaribelHernandez Rienda, LorenaGarcia Carbonero, RocioHernando, JorgeCustodio, AnaAnton Pascual, BeatrizGomez, MartaMilla, Samara PalmaSuarez, LorenaBellver, MartaAlonso, VicenteSerrano, RaquelValdés, NuriaMelian, MarcosFebrero, BeatrizSampedro Nuñez, Miguel AntonioBiarnes, JosefinaDíaz-Pérez, José ÁngelMolina-Cerrillo, JavierLópez López, Carlos|||0000-0002-8901-741XNutritional statusMalnutritionSarcopeniaNeuroendocrine neoplasmsGastroenteropancreaticPatients with advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have impaired nutritional and physical performance due to the cancer pathophysiology and its treatment. The NUTRIGETNE study sought to characterize the nutritional status of patients with advanced GEP-NENs in Spain. This is a cross-sectional study that included patients with advanced GEP-NENs receiving active oncological treatment. Patients had a complete physical examination, anthropometry, bioelectrical impedance, dynamometry, laboratory analysis, and a comprehensive nutritional risk assessment. Malnutrition was defined according to Global Leadership Initiative on Malnutrition (GLIM) criteria. The study included 399 patients out of the 400 planned (Pearson?s ?2; ? 0.05). Median age was 62 years (22-83). Tumors most commonly originated in the small intestine (43.9%) and the pancreas (41.6%), 94.7% were metastatic, and 36.7%, 49.4%, and 12.5% were G1, G2, and G3, respectively. Malnutrition prevalence was 61.9% (25.8% moderate; 36.1% severe), mainly due to low muscle mass (50.9%), which was the most prevalent GLIM phenotypic criteria. Moreover, malnutrition showed a correlation with decreased hand grip strength (mean 23 vs 31.9 kg; P <.001) and phase angle (median 5o vs 5.6o; P <.001). The prevalence of sarcopenia was 15%. Malnutrition was more frequent in patients with diabetes (74.4% vs 56.7%; P <.001), NECs (82.1% vs 60.3%; P =.062), and in those treated with chemotherapy (71.2% vs 59.7%; P =.058), whereas it did not correlate with tumor origin (P =.507), histological grade (P =.781), or functionality (P =.465). Malnutrition was correlated to body mass index (BMI) (P =.015), although it was also diagnosed in a high proportion of patients with no weight loss (63%, 54.1%, and 65.1% of patients with normal BMI, overweight, and obesity, respectively). Cachexia was present in 109 (27.3%) patients. Malnutrition is very prevalent and commonly underdiagnosed in patients with GEP-NENs. It is associated with sarcopenia and a worse QoL, requiring a multifactorial nutritional assessment. Certain factors such as the presence of diabetes may require closer monitoring due to a higher risk of malnutrition.This study was funded by GETNE with the collaboration of Ipsen and Vegenat. The funders had no role in the design and conduct of the study.Oxford University PressUniversidad de Cantabria20252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/36663The oncologist, 2025, 30(2), oyae343reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/366632026-06-02T12:39:31Z
dc.title.none.fl_str_mv Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
title Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
spellingShingle Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
Del Olmo García, Maribel
Nutritional status
Malnutrition
Sarcopenia
Neuroendocrine neoplasms
Gastroenteropancreatic
title_short Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
title_full Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
title_fullStr Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
title_full_unstemmed Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
title_sort Nutritional status and quality of life of patients with advanced gastroenteropancreatic neuroendocrine neoplasms in Spain: the NUTRIGETNE (GETNE-S2109) study
dc.creator.none.fl_str_mv Del Olmo García, Maribel
Hernandez Rienda, Lorena
Garcia Carbonero, Rocio
Hernando, Jorge
Custodio, Ana
Anton Pascual, Beatriz
Gomez, Marta
Milla, Samara Palma
Suarez, Lorena
Bellver, Marta
Alonso, Vicente
Serrano, Raquel
Valdés, Nuria
Melian, Marcos
Febrero, Beatriz
Sampedro Nuñez, Miguel Antonio
Biarnes, Josefina
Díaz-Pérez, José Ángel
Molina-Cerrillo, Javier
López López, Carlos|||0000-0002-8901-741X
author Del Olmo García, Maribel
author_facet Del Olmo García, Maribel
Hernandez Rienda, Lorena
Garcia Carbonero, Rocio
Hernando, Jorge
Custodio, Ana
Anton Pascual, Beatriz
Gomez, Marta
Milla, Samara Palma
Suarez, Lorena
Bellver, Marta
Alonso, Vicente
Serrano, Raquel
Valdés, Nuria
Melian, Marcos
Febrero, Beatriz
Sampedro Nuñez, Miguel Antonio
Biarnes, Josefina
Díaz-Pérez, José Ángel
Molina-Cerrillo, Javier
López López, Carlos|||0000-0002-8901-741X
author_role author
author2 Hernandez Rienda, Lorena
Garcia Carbonero, Rocio
Hernando, Jorge
Custodio, Ana
Anton Pascual, Beatriz
Gomez, Marta
Milla, Samara Palma
Suarez, Lorena
Bellver, Marta
Alonso, Vicente
Serrano, Raquel
Valdés, Nuria
Melian, Marcos
Febrero, Beatriz
Sampedro Nuñez, Miguel Antonio
Biarnes, Josefina
Díaz-Pérez, José Ángel
Molina-Cerrillo, Javier
López López, Carlos|||0000-0002-8901-741X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Nutritional status
Malnutrition
Sarcopenia
Neuroendocrine neoplasms
Gastroenteropancreatic
topic Nutritional status
Malnutrition
Sarcopenia
Neuroendocrine neoplasms
Gastroenteropancreatic
description Patients with advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have impaired nutritional and physical performance due to the cancer pathophysiology and its treatment. The NUTRIGETNE study sought to characterize the nutritional status of patients with advanced GEP-NENs in Spain. This is a cross-sectional study that included patients with advanced GEP-NENs receiving active oncological treatment. Patients had a complete physical examination, anthropometry, bioelectrical impedance, dynamometry, laboratory analysis, and a comprehensive nutritional risk assessment. Malnutrition was defined according to Global Leadership Initiative on Malnutrition (GLIM) criteria. The study included 399 patients out of the 400 planned (Pearson?s ?2; ? 0.05). Median age was 62 years (22-83). Tumors most commonly originated in the small intestine (43.9%) and the pancreas (41.6%), 94.7% were metastatic, and 36.7%, 49.4%, and 12.5% were G1, G2, and G3, respectively. Malnutrition prevalence was 61.9% (25.8% moderate; 36.1% severe), mainly due to low muscle mass (50.9%), which was the most prevalent GLIM phenotypic criteria. Moreover, malnutrition showed a correlation with decreased hand grip strength (mean 23 vs 31.9 kg; P <.001) and phase angle (median 5o vs 5.6o; P <.001). The prevalence of sarcopenia was 15%. Malnutrition was more frequent in patients with diabetes (74.4% vs 56.7%; P <.001), NECs (82.1% vs 60.3%; P =.062), and in those treated with chemotherapy (71.2% vs 59.7%; P =.058), whereas it did not correlate with tumor origin (P =.507), histological grade (P =.781), or functionality (P =.465). Malnutrition was correlated to body mass index (BMI) (P =.015), although it was also diagnosed in a high proportion of patients with no weight loss (63%, 54.1%, and 65.1% of patients with normal BMI, overweight, and obesity, respectively). Cachexia was present in 109 (27.3%) patients. Malnutrition is very prevalent and commonly underdiagnosed in patients with GEP-NENs. It is associated with sarcopenia and a worse QoL, requiring a multifactorial nutritional assessment. Certain factors such as the presence of diabetes may require closer monitoring due to a higher risk of malnutrition.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/36663
url https://hdl.handle.net/10902/36663
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv The oncologist, 2025, 30(2), oyae343
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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