Exosomes in Bone Sarcomas: Key Players in Metastasis

Bone sarcomas are rare cancers which often present with metastatic disease and are still associated with poor survival rates. Studies in the last decade have identified that exosomes, a type of extracellular vesicle released by cells, play an important role in tumour progression and dissemination. T...

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Detalles Bibliográficos
Autores: Chicón Bosch, Mariona, Tirado, Oscar M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173727
Acceso en línea:https://hdl.handle.net/2445/173727
Access Level:acceso abierto
Palabra clave:Osteosarcoma
Metàstasi
Metastasis
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spelling Exosomes in Bone Sarcomas: Key Players in MetastasisChicón Bosch, MarionaTirado, Oscar M.OsteosarcomaMetàstasiOsteosarcomaMetastasisBone sarcomas are rare cancers which often present with metastatic disease and are still associated with poor survival rates. Studies in the last decade have identified that exosomes, a type of extracellular vesicle released by cells, play an important role in tumour progression and dissemination. Through the transfer of their cargo (RNAs, proteins, and lipids) across cells, they are involved in cellular cross-talk and can induce changes in cellular behaviour. Exosomes have been shown to be important in metastasis organotropism, induction of angiogenesis and vascular permeability, the education of cells towards a pro-metastatic phenotype or the interaction between stromal and tumour cells. Due to the importance exosomes have in disease progression and the high incidence of metastasis in bone sarcomas, recent studies have evaluated the implications of these extracellular vesicles in bone sarcomas. In this review, we discuss the studies that evaluate the role of exosomes in osteosarcoma, Ewing sarcoma, and preliminary data on chondrosarcoma.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/173727Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cells9010241Cells, 2020, vol. 9, num. 1https://doi.org/10.3390/cells9010241cc by (c) Chicón Bosch et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1737272026-05-27T06:46:51Z
dc.title.none.fl_str_mv Exosomes in Bone Sarcomas: Key Players in Metastasis
title Exosomes in Bone Sarcomas: Key Players in Metastasis
spellingShingle Exosomes in Bone Sarcomas: Key Players in Metastasis
Chicón Bosch, Mariona
Osteosarcoma
Metàstasi
Osteosarcoma
Metastasis
title_short Exosomes in Bone Sarcomas: Key Players in Metastasis
title_full Exosomes in Bone Sarcomas: Key Players in Metastasis
title_fullStr Exosomes in Bone Sarcomas: Key Players in Metastasis
title_full_unstemmed Exosomes in Bone Sarcomas: Key Players in Metastasis
title_sort Exosomes in Bone Sarcomas: Key Players in Metastasis
dc.creator.none.fl_str_mv Chicón Bosch, Mariona
Tirado, Oscar M.
author Chicón Bosch, Mariona
author_facet Chicón Bosch, Mariona
Tirado, Oscar M.
author_role author
author2 Tirado, Oscar M.
author2_role author
dc.subject.none.fl_str_mv Osteosarcoma
Metàstasi
Osteosarcoma
Metastasis
topic Osteosarcoma
Metàstasi
Osteosarcoma
Metastasis
description Bone sarcomas are rare cancers which often present with metastatic disease and are still associated with poor survival rates. Studies in the last decade have identified that exosomes, a type of extracellular vesicle released by cells, play an important role in tumour progression and dissemination. Through the transfer of their cargo (RNAs, proteins, and lipids) across cells, they are involved in cellular cross-talk and can induce changes in cellular behaviour. Exosomes have been shown to be important in metastasis organotropism, induction of angiogenesis and vascular permeability, the education of cells towards a pro-metastatic phenotype or the interaction between stromal and tumour cells. Due to the importance exosomes have in disease progression and the high incidence of metastasis in bone sarcomas, recent studies have evaluated the implications of these extracellular vesicles in bone sarcomas. In this review, we discuss the studies that evaluate the role of exosomes in osteosarcoma, Ewing sarcoma, and preliminary data on chondrosarcoma.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173727
url https://hdl.handle.net/2445/173727
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cells9010241
Cells, 2020, vol. 9, num. 1
https://doi.org/10.3390/cells9010241
dc.rights.none.fl_str_mv cc by (c) Chicón Bosch et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Chicón Bosch et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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