In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic

This study evaluates the potential of strains of Lactobacillus and Saccharomyces cerevisiae to reduce inorganic arsenic [iAs, As(III)+As(V)] bioavailability. Removal of iAs from aqueous solutions by these strains was evaluated and their effect on iAs bioaccessibility was analyzed by in vitro gastroi...

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Detalles Bibliográficos
Autores: Clemente, María Jesús, Vivó, María de los Ángeles, Puig, Sergi, Zúñiga, Manuel, Monedero, Vicente, Devesa, Vicenta, Vélez, Dinoraz
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/206901
Acceso en línea:http://hdl.handle.net/10261/206901
Access Level:acceso abierto
Palabra clave:Inorganic arsenic
Bioaccessibility
Intestinal absorption
Bioavailability
Saccharomyces cerevisiae
Lactobacillus
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spelling In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenicClemente, María JesúsVivó, María de los ÁngelesPuig, SergiZúñiga, ManuelMonedero, VicenteDevesa, VicentaVélez, DinorazInorganic arsenicBioaccessibilityIntestinal absorptionBioavailabilitySaccharomyces cerevisiaeLactobacillusThis study evaluates the potential of strains of Lactobacillus and Saccharomyces cerevisiae to reduce inorganic arsenic [iAs, As(III)+As(V)] bioavailability. Removal of iAs from aqueous solutions by these strains was evaluated and their effect on iAs bioaccessibility was analyzed by in vitro gastrointestinal digestion. The effect of the strains on iAs absorption was also tested, using intestinal cells. The results showed that iAs removal by the yeast strains was low (<10%). In contrast, some lactobacilli substantially reduced As(V) concentration in solution (25–40%) but only when the concentration of phosphate was ≤1 mM. Both microorganisms were able to reduce cellular transport of iAs added as aqueous solution (11–58%). Moreover, a strain of Lactobacillus plantarum reduced cellular transport of iAs from rice by up to 45%. We conclude that, in vitro, some lactobacilli and yeasts could reduce intestinal absorption of inorganic As present in water and food, and consequently reduce its bioavailability.This work was supported by the former Spanish Ministry of Economy and Competitiveness through project AGL2015-68920-R, for which the authors are deeply indebted.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/206901reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-68920-Rhttps://doi.org/10.1016/j.lwt.2020.109272Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2069012026-05-22T06:33:51Z
dc.title.none.fl_str_mv In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
title In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
spellingShingle In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
Clemente, María Jesús
Inorganic arsenic
Bioaccessibility
Intestinal absorption
Bioavailability
Saccharomyces cerevisiae
Lactobacillus
title_short In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
title_full In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
title_fullStr In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
title_full_unstemmed In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
title_sort In vitro evaluation of the efficacy of lactobacilli and yeasts in reducing bioavailability of inorganic arsenic
dc.creator.none.fl_str_mv Clemente, María Jesús
Vivó, María de los Ángeles
Puig, Sergi
Zúñiga, Manuel
Monedero, Vicente
Devesa, Vicenta
Vélez, Dinoraz
author Clemente, María Jesús
author_facet Clemente, María Jesús
Vivó, María de los Ángeles
Puig, Sergi
Zúñiga, Manuel
Monedero, Vicente
Devesa, Vicenta
Vélez, Dinoraz
author_role author
author2 Vivó, María de los Ángeles
Puig, Sergi
Zúñiga, Manuel
Monedero, Vicente
Devesa, Vicenta
Vélez, Dinoraz
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Inorganic arsenic
Bioaccessibility
Intestinal absorption
Bioavailability
Saccharomyces cerevisiae
Lactobacillus
topic Inorganic arsenic
Bioaccessibility
Intestinal absorption
Bioavailability
Saccharomyces cerevisiae
Lactobacillus
description This study evaluates the potential of strains of Lactobacillus and Saccharomyces cerevisiae to reduce inorganic arsenic [iAs, As(III)+As(V)] bioavailability. Removal of iAs from aqueous solutions by these strains was evaluated and their effect on iAs bioaccessibility was analyzed by in vitro gastrointestinal digestion. The effect of the strains on iAs absorption was also tested, using intestinal cells. The results showed that iAs removal by the yeast strains was low (<10%). In contrast, some lactobacilli substantially reduced As(V) concentration in solution (25–40%) but only when the concentration of phosphate was ≤1 mM. Both microorganisms were able to reduce cellular transport of iAs added as aqueous solution (11–58%). Moreover, a strain of Lactobacillus plantarum reduced cellular transport of iAs from rice by up to 45%. We conclude that, in vitro, some lactobacilli and yeasts could reduce intestinal absorption of inorganic As present in water and food, and consequently reduce its bioavailability.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/206901
url http://hdl.handle.net/10261/206901
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-68920-R
https://doi.org/10.1016/j.lwt.2020.109272
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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