Flower development as an interplay between dynamical physical field and genetic networks
In this paper we propose a model to describe the mechanisms by which undifferentiated cells attain gene configurations underlying cell fate determination during morphogenesis. Despite the complicated mechanisms that surely intervene in this process, it is clear that the fundamental fact is that cell...
| Autores: | , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2010 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/69634 |
| Acesso em linha: | https://hdl.handle.net/2445/69634 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Morfogènesi Desenvolupament de les plantes Flors Diferenciació cel·lular Arabidopsis thaliana Morphogenesis Plant development Flowers Cell diferentiation |
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Flower development as an interplay between dynamical physical field and genetic networksBarrio, Rafael ÁngelHernández Machado, AuroraVarea, C.Romero-Arias, José RobertoAlvarez-Buylla, ElenaMorfogènesiDesenvolupament de les plantesFlorsDiferenciació cel·lularArabidopsis thalianaMorphogenesisPlant developmentFlowersCell diferentiationArabidopsis thalianaIn this paper we propose a model to describe the mechanisms by which undifferentiated cells attain gene configurations underlying cell fate determination during morphogenesis. Despite the complicated mechanisms that surely intervene in this process, it is clear that the fundamental fact is that cells obtain spatial and temporal information that bias their destiny. Our main hypothesis assumes that there is at least one macroscopic field that breaks the symmetry of space at a given time. This field provides the information required for the process of cell differentiation to occur by being dynamically coupled to a signal transduction mechanism that, in turn, acts directly upon the gene regulatory network (GRN) underlying cell-fate decisions within cells. We illustrate and test our proposal with a GRN model grounded on experimental data for cell fate specification during organ formation in early Arabidopsis thaliana flower development. We show that our model is able to recover the multigene configurations characteristic of sepal, petal, stamen and carpel primordial cells arranged in concentric rings, in a similar pattern to that observed during actual floral organ determination. Such pattern is robust to alterations of the model parameters and simulated failures predict altered spatio-temporal patterns that mimic those described for several mutants. Furthermore, simulated alterations in the physical fields predict a pattern equivalent to that found in Lacandonia schismatica, the only flowering species with central stamens surrounded by carpels.Public Library of Science (PLoS)2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/69634Articles publicats en revistes (Física Quàntica i Astrofísica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0013523PLoS One, 2010, vol. 5, num. 10, p. e13523-e13523http://dx.doi.org/10.1371/journal.pone.0013523cc-by (c) Barrio, Rafael Ángel et al., 2010http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/696342026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Flower development as an interplay between dynamical physical field and genetic networks |
| title |
Flower development as an interplay between dynamical physical field and genetic networks |
| spellingShingle |
Flower development as an interplay between dynamical physical field and genetic networks Barrio, Rafael Ángel Morfogènesi Desenvolupament de les plantes Flors Diferenciació cel·lular Arabidopsis thaliana Morphogenesis Plant development Flowers Cell diferentiation Arabidopsis thaliana |
| title_short |
Flower development as an interplay between dynamical physical field and genetic networks |
| title_full |
Flower development as an interplay between dynamical physical field and genetic networks |
| title_fullStr |
Flower development as an interplay between dynamical physical field and genetic networks |
| title_full_unstemmed |
Flower development as an interplay between dynamical physical field and genetic networks |
| title_sort |
Flower development as an interplay between dynamical physical field and genetic networks |
| dc.creator.none.fl_str_mv |
Barrio, Rafael Ángel Hernández Machado, Aurora Varea, C. Romero-Arias, José Roberto Alvarez-Buylla, Elena |
| author |
Barrio, Rafael Ángel |
| author_facet |
Barrio, Rafael Ángel Hernández Machado, Aurora Varea, C. Romero-Arias, José Roberto Alvarez-Buylla, Elena |
| author_role |
author |
| author2 |
Hernández Machado, Aurora Varea, C. Romero-Arias, José Roberto Alvarez-Buylla, Elena |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Morfogènesi Desenvolupament de les plantes Flors Diferenciació cel·lular Arabidopsis thaliana Morphogenesis Plant development Flowers Cell diferentiation Arabidopsis thaliana |
| topic |
Morfogènesi Desenvolupament de les plantes Flors Diferenciació cel·lular Arabidopsis thaliana Morphogenesis Plant development Flowers Cell diferentiation Arabidopsis thaliana |
| description |
In this paper we propose a model to describe the mechanisms by which undifferentiated cells attain gene configurations underlying cell fate determination during morphogenesis. Despite the complicated mechanisms that surely intervene in this process, it is clear that the fundamental fact is that cells obtain spatial and temporal information that bias their destiny. Our main hypothesis assumes that there is at least one macroscopic field that breaks the symmetry of space at a given time. This field provides the information required for the process of cell differentiation to occur by being dynamically coupled to a signal transduction mechanism that, in turn, acts directly upon the gene regulatory network (GRN) underlying cell-fate decisions within cells. We illustrate and test our proposal with a GRN model grounded on experimental data for cell fate specification during organ formation in early Arabidopsis thaliana flower development. We show that our model is able to recover the multigene configurations characteristic of sepal, petal, stamen and carpel primordial cells arranged in concentric rings, in a similar pattern to that observed during actual floral organ determination. Such pattern is robust to alterations of the model parameters and simulated failures predict altered spatio-temporal patterns that mimic those described for several mutants. Furthermore, simulated alterations in the physical fields predict a pattern equivalent to that found in Lacandonia schismatica, the only flowering species with central stamens surrounded by carpels. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/69634 |
| url |
https://hdl.handle.net/2445/69634 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0013523 PLoS One, 2010, vol. 5, num. 10, p. e13523-e13523 http://dx.doi.org/10.1371/journal.pone.0013523 |
| dc.rights.none.fl_str_mv |
cc-by (c) Barrio, Rafael Ángel et al., 2010 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Barrio, Rafael Ángel et al., 2010 http://creativecommons.org/licenses/by/3.0/es |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science (PLoS) |
| publisher.none.fl_str_mv |
Public Library of Science (PLoS) |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Física Quàntica i Astrofísica) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15.300719 |