Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging

Alterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an incre...

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Detalles Bibliográficos
Autores: Terrasa, Juan Lorenzo, Montoya, Pedro, Sitges, Carolina, van der Meulen, Marian, Anton, Fernand, González-Roldán, Ana María
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23196
Acceso en línea:https://hdl.handle.net/20.500.12105/23196
Access Level:acceso abierto
Palabra clave:Aging
Pain
Brain activity
EEG
fMRI
Resting-state
Anterior cingulate cortex
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spelling Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in AgingTerrasa, Juan LorenzoMontoya, PedroSitges, Carolinavan der Meulen, MarianAnton, FernandGonzález-Roldán, Ana MaríaAgingPainBrain activityEEGfMRIResting-stateAnterior cingulate cortexAlterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an increased pain perception in older adults. For this purpose, we compared EEG current source density and fMRI functional-connectivity at rest in older (n = 20, 66.21 ± 3.08 years) and younger adults (n = 21, 20.71 ± 2.30 years) and correlated those brain activity parameters with pain intensity and unpleasantness ratings elicited by painful stimulation. We found an age-related increase in beta2 and beta3 activity in temporal, frontal, and limbic areas, and a decrease in alpha activity in frontal areas. Moreover, older participants displayed increased functional connectivity in the anterior cingulate cortex (ACC) and the insula with precentral and postcentral gyrus. Finally, ACC beta3 activity was positively correlated with pain intensity and unpleasantness ratings in older, and ACC-precentral/postcentral gyrus connectivity was positively correlated with unpleasantness ratings in older and younger participants. These results reveal that ACC resting-state hyperactivity is a stable trait of brain aging and may underlie their characteristic altered pain perception.Frontiers Media20242024-09-1820212021-01-0120212021-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23196reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PSI2016-78637-P Not availableES PSI2017-88388-C4-1-R-AEI FEDERES PSI2015-66295-R Not availableES PID2019-110096GBI00 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/231962026-06-12T12:43:37Z
dc.title.none.fl_str_mv Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
title Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
spellingShingle Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
Terrasa, Juan Lorenzo
Aging
Pain
Brain activity
EEG
fMRI
Resting-state
Anterior cingulate cortex
title_short Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
title_full Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
title_fullStr Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
title_full_unstemmed Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
title_sort Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
dc.creator.none.fl_str_mv Terrasa, Juan Lorenzo
Montoya, Pedro
Sitges, Carolina
van der Meulen, Marian
Anton, Fernand
González-Roldán, Ana María
author Terrasa, Juan Lorenzo
author_facet Terrasa, Juan Lorenzo
Montoya, Pedro
Sitges, Carolina
van der Meulen, Marian
Anton, Fernand
González-Roldán, Ana María
author_role author
author2 Montoya, Pedro
Sitges, Carolina
van der Meulen, Marian
Anton, Fernand
González-Roldán, Ana María
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Aging
Pain
Brain activity
EEG
fMRI
Resting-state
Anterior cingulate cortex
topic Aging
Pain
Brain activity
EEG
fMRI
Resting-state
Anterior cingulate cortex
description Alterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an increased pain perception in older adults. For this purpose, we compared EEG current source density and fMRI functional-connectivity at rest in older (n = 20, 66.21 ± 3.08 years) and younger adults (n = 21, 20.71 ± 2.30 years) and correlated those brain activity parameters with pain intensity and unpleasantness ratings elicited by painful stimulation. We found an age-related increase in beta2 and beta3 activity in temporal, frontal, and limbic areas, and a decrease in alpha activity in frontal areas. Moreover, older participants displayed increased functional connectivity in the anterior cingulate cortex (ACC) and the insula with precentral and postcentral gyrus. Finally, ACC beta3 activity was positively correlated with pain intensity and unpleasantness ratings in older, and ACC-precentral/postcentral gyrus connectivity was positively correlated with unpleasantness ratings in older and younger participants. These results reveal that ACC resting-state hyperactivity is a stable trait of brain aging and may underlie their characteristic altered pain perception.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
2024
2024-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23196
url https://hdl.handle.net/20.500.12105/23196
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PSI2016-78637-P Not available
ES PSI2017-88388-C4-1-R-AEI FEDER
ES PSI2015-66295-R Not available
ES PID2019-110096GBI00 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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