Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia

Introduction Although there is evidence that higher cognitive reserve (CR) is a protective factor and it has been related to better prognosis, there have been no studies to date that have explored the CR level and its impact in clinical, neurocognitive and lifestyle outcomes according to the stage o...

Descripción completa

Detalles Bibliográficos
Autores: Amoretti Guadall, Silvia, Arranz, Belén, Anmella, Gerard, Bernardo Arroyo, Miquel, Alfonso, Miqueu, Hernández, Carla, García-Portilla González, María Paz, 1962-, González-Blanco, Leticia, Safont, Gemma, Garrido, Ignacio, Sanchez Autet, Mónica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::d9c9e09f7d4020697979fb3e0cb80061
Acceso en línea:https://hdl.handle.net/2445/229254
Access Level:acceso abierto
Palabra clave:Esquizofrènia
Neuropsicologia clínica
Cognició
Schizophrenia
Clinical neuropsychology
Cognition
id ES_c2c20e6e6d493cd5b1391c9f28afc4c5
oai_identifier_str oai:dnet:recercat____::d9c9e09f7d4020697979fb3e0cb80061
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophreniaAmoretti Guadall, SilviaArranz, BelénAnmella, GerardBernardo Arroyo, MiquelAlfonso, MiqueuHernández, CarlaGarcía-Portilla González, María Paz, 1962-González-Blanco, LeticiaSafont, GemmaGarrido, IgnacioSanchez Autet, MónicaEsquizofrèniaNeuropsicologia clínicaCognicióSchizophreniaClinical neuropsychologyCognitionIntroduction Although there is evidence that higher cognitive reserve (CR) is a protective factor and it has been related to better prognosis, there have been no studies to date that have explored the CR level and its impact in clinical, neurocognitive and lifestyle outcomes according to the stage of the disease: early stage of psychosis (ESP) or chronic schizophrenia (SCZ). Material and methods A total of 60 patients in the ESP and 225 patients with SCZ were enrolled in the study. To test the predictive capacity of CR for each diagnostic group, a logistic regression analysis was conducted. Hierarchical linear regression analyses were performed to explore the associations between CR and different outcomes. The mediation analyses were performed according to the principles of Baron and Kenny. Results Patients with SCZ showed lower CR than those in the ESP (p < 0.001). CR correctly classified 79.6% of the cases (p < 0.001; Exp(B) = 1.062). In ESP group, CR was related to working memory (p = 0.030) and negative symptoms (p = 0.027). CR (t = 3.925, p < 0.001) and cannabis use (t = 2.023, p = 0.048) explained 26.7% of the variance on functioning (p = 0.003). In patients with SCZ, CR predicted all cognitive domains, negative symptoms (R2 = 0.091, p = 0.001) and functioning (R2 = 0.074, p = 0.005). In both ESP and SCZ groups, higher CR was associated with lower body mass index and circumference. In ESP group, the effect of adherence to Mediterranean diet on functioning (p = 0.037) was mediated by CR level (p = 0.003).Elsevier España2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/229254Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.sjpmh.2024.01.003Spanish Journal of Psychiatry and Mental Health, 2024, vol. 17, num. 3, p. 168-174https://doi.org/10.1016/j.sjpmh.2024.01.003cc-by (c) Amoretti Guadall, Silvia et al., 2024http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::d9c9e09f7d4020697979fb3e0cb800612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
title Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
spellingShingle Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
Amoretti Guadall, Silvia
Esquizofrènia
Neuropsicologia clínica
Cognició
Schizophrenia
Clinical neuropsychology
Cognition
title_short Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
title_full Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
title_fullStr Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
title_full_unstemmed Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
title_sort Impact of cognitive reserve in clinical, neurocognitive and lifestyle factors in chronic schizophrenia and early stages of schizophrenia
dc.creator.none.fl_str_mv Amoretti Guadall, Silvia
Arranz, Belén
Anmella, Gerard
Bernardo Arroyo, Miquel
Alfonso, Miqueu
Hernández, Carla
García-Portilla González, María Paz, 1962-
González-Blanco, Leticia
Safont, Gemma
Garrido, Ignacio
Sanchez Autet, Mónica
author Amoretti Guadall, Silvia
author_facet Amoretti Guadall, Silvia
Arranz, Belén
Anmella, Gerard
Bernardo Arroyo, Miquel
Alfonso, Miqueu
Hernández, Carla
García-Portilla González, María Paz, 1962-
González-Blanco, Leticia
Safont, Gemma
Garrido, Ignacio
Sanchez Autet, Mónica
author_role author
author2 Arranz, Belén
Anmella, Gerard
Bernardo Arroyo, Miquel
Alfonso, Miqueu
Hernández, Carla
García-Portilla González, María Paz, 1962-
González-Blanco, Leticia
Safont, Gemma
Garrido, Ignacio
Sanchez Autet, Mónica
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esquizofrènia
Neuropsicologia clínica
Cognició
Schizophrenia
Clinical neuropsychology
Cognition
topic Esquizofrènia
Neuropsicologia clínica
Cognició
Schizophrenia
Clinical neuropsychology
Cognition
description Introduction Although there is evidence that higher cognitive reserve (CR) is a protective factor and it has been related to better prognosis, there have been no studies to date that have explored the CR level and its impact in clinical, neurocognitive and lifestyle outcomes according to the stage of the disease: early stage of psychosis (ESP) or chronic schizophrenia (SCZ). Material and methods A total of 60 patients in the ESP and 225 patients with SCZ were enrolled in the study. To test the predictive capacity of CR for each diagnostic group, a logistic regression analysis was conducted. Hierarchical linear regression analyses were performed to explore the associations between CR and different outcomes. The mediation analyses were performed according to the principles of Baron and Kenny. Results Patients with SCZ showed lower CR than those in the ESP (p < 0.001). CR correctly classified 79.6% of the cases (p < 0.001; Exp(B) = 1.062). In ESP group, CR was related to working memory (p = 0.030) and negative symptoms (p = 0.027). CR (t = 3.925, p < 0.001) and cannabis use (t = 2.023, p = 0.048) explained 26.7% of the variance on functioning (p = 0.003). In patients with SCZ, CR predicted all cognitive domains, negative symptoms (R2 = 0.091, p = 0.001) and functioning (R2 = 0.074, p = 0.005). In both ESP and SCZ groups, higher CR was associated with lower body mass index and circumference. In ESP group, the effect of adherence to Mediterranean diet on functioning (p = 0.037) was mediated by CR level (p = 0.003).
publishDate 2024
dc.date.none.fl_str_mv 2024
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229254
url https://hdl.handle.net/2445/229254
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.sjpmh.2024.01.003
Spanish Journal of Psychiatry and Mental Health, 2024, vol. 17, num. 3, p. 168-174
https://doi.org/10.1016/j.sjpmh.2024.01.003
dc.rights.none.fl_str_mv cc-by (c) Amoretti Guadall, Silvia et al., 2024
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Amoretti Guadall, Silvia et al., 2024
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier España
publisher.none.fl_str_mv Elsevier España
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418714934280192
score 15,812429

Similares en LA Referencia