Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

Introduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1...

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Autores: Peñalver Argüeso, Belén, Castaño Vinyals, Gemma, Kogevinas, Manolis, Pérez-Gómez, Beatriz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/68480
Acceso en línea:http://hdl.handle.net/10230/68480
http://dx.doi.org/10.18332/tid/174132
Access Level:acceso abierto
Palabra clave:HER2
Breast cancer
Hormone receptor
Obesity
Smoking
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spelling Smoking history and breast cancer risk by pathological subtype: MCC-Spain studyPeñalver Argüeso, BelénCastaño Vinyals, GemmaKogevinas, ManolisPérez-Gómez, BeatrizHER2Breast cancerHormone receptorObesitySmokingIntroduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. Results: Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk. Conclusions: Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.European Publishing202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/68480http://dx.doi.org/10.18332/tid/174132reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésTob Induc Dis. 2023 Nov 30;21:157© 2023 Peñalver-Argüeso B. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/684802026-06-12T07:21:37Z
dc.title.none.fl_str_mv Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
spellingShingle Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
Peñalver Argüeso, Belén
HER2
Breast cancer
Hormone receptor
Obesity
Smoking
title_short Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_fullStr Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full_unstemmed Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_sort Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
dc.creator.none.fl_str_mv Peñalver Argüeso, Belén
Castaño Vinyals, Gemma
Kogevinas, Manolis
Pérez-Gómez, Beatriz
author Peñalver Argüeso, Belén
author_facet Peñalver Argüeso, Belén
Castaño Vinyals, Gemma
Kogevinas, Manolis
Pérez-Gómez, Beatriz
author_role author
author2 Castaño Vinyals, Gemma
Kogevinas, Manolis
Pérez-Gómez, Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv HER2
Breast cancer
Hormone receptor
Obesity
Smoking
topic HER2
Breast cancer
Hormone receptor
Obesity
Smoking
description Introduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. Results: Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk. Conclusions: Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/68480
http://dx.doi.org/10.18332/tid/174132
url http://hdl.handle.net/10230/68480
http://dx.doi.org/10.18332/tid/174132
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Tob Induc Dis. 2023 Nov 30;21:157
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv European Publishing
publisher.none.fl_str_mv European Publishing
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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