Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept

To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In t...

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Detalles Bibliográficos
Autores: Multigner, Marta, Morales, Irene, Giacomone, Fernando, Presa Muñoz De Toro, Patricia Marcela De La, Benavente, Rosario, Torres, Belén, Mantovani, Diego, Rams, Joaquín
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/5066
Acceso en línea:https://hdl.handle.net/20.500.14352/5066
Access Level:acceso abierto
Palabra clave:538.9
Magnetic nanoparticles
Heating efficiency
Hyperthermia
Stability
Size
Biodegradable nanocomposite
PLLA
Radiofrequency electromagnetic field
Física de materiales
Física del estado sólido
2211 Física del Estado Sólido
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spelling Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of conceptMultigner, MartaMorales, IreneGiacomone, FernandoPresa Muñoz De Toro, Patricia Marcela De LaBenavente, RosarioTorres, BelénMantovani, DiegoRams, Joaquín538.9Magnetic nanoparticlesHeating efficiencyHyperthermiaStabilitySizeBiodegradable nanocompositePLLARadiofrequency electromagnetic fieldFísica de materialesFísica del estado sólido2211 Física del Estado SólidoTo modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range f center dot H < 5 center dot x 10_(9) Am_(-1) center dot s_(-1). Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment.MDPIUniversidad Complutense de Madrid20212021-08-0120212021-08-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/5066reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/50662026-06-02T12:44:21Z
dc.title.none.fl_str_mv Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
title Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
spellingShingle Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
Multigner, Marta
538.9
Magnetic nanoparticles
Heating efficiency
Hyperthermia
Stability
Size
Biodegradable nanocomposite
PLLA
Radiofrequency electromagnetic field
Física de materiales
Física del estado sólido
2211 Física del Estado Sólido
title_short Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
title_full Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
title_fullStr Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
title_full_unstemmed Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
title_sort Modulation of crystallinity through radiofrequency electromagnetic fields in PLLA/magnetic nanoparticles composites: A proof of concept
dc.creator.none.fl_str_mv Multigner, Marta
Morales, Irene
Giacomone, Fernando
Presa Muñoz De Toro, Patricia Marcela De La
Benavente, Rosario
Torres, Belén
Mantovani, Diego
Rams, Joaquín
author Multigner, Marta
author_facet Multigner, Marta
Morales, Irene
Giacomone, Fernando
Presa Muñoz De Toro, Patricia Marcela De La
Benavente, Rosario
Torres, Belén
Mantovani, Diego
Rams, Joaquín
author_role author
author2 Morales, Irene
Giacomone, Fernando
Presa Muñoz De Toro, Patricia Marcela De La
Benavente, Rosario
Torres, Belén
Mantovani, Diego
Rams, Joaquín
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 538.9
Magnetic nanoparticles
Heating efficiency
Hyperthermia
Stability
Size
Biodegradable nanocomposite
PLLA
Radiofrequency electromagnetic field
Física de materiales
Física del estado sólido
2211 Física del Estado Sólido
topic 538.9
Magnetic nanoparticles
Heating efficiency
Hyperthermia
Stability
Size
Biodegradable nanocomposite
PLLA
Radiofrequency electromagnetic field
Física de materiales
Física del estado sólido
2211 Física del Estado Sólido
description To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range f center dot H < 5 center dot x 10_(9) Am_(-1) center dot s_(-1). Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-08-01
2021
2021-08-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/5066
url https://hdl.handle.net/20.500.14352/5066
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418713207275520
score 15.300719

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