Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery

INTRODUCTION: miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of...

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Autores: Cereijo Téllez, Rubén, Taxerås, Siri D., Piquer-Garcia, Irene, Pellitero, Silvia, Martínez Cáceres, Eva María, Tarascó, Jordi, Moreno, Pau, Balibrea, José, Puig-Domingo, Manel, Jiménez-Pavón, David, Lerin, Carles, Villarroya i Gombau, Francesc, Sánchez-Infantes, David
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218091
Acceso en línea:https://hdl.handle.net/2445/218091
Access Level:acceso abierto
Palabra clave:Cirurgia de l'obesitat
Teixit adipós
Obesity surgery
Adipose tissues
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spelling Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgeryCereijo Téllez, RubénTaxerås, Siri D.Piquer-Garcia, IrenePellitero, SilviaMartínez Cáceres, Eva MaríaTarascó, JordiMoreno, PauBalibrea, JoséPuig-Domingo, ManelJiménez-Pavón, DavidLerin, CarlesVillarroya i Gombau, FrancescSánchez-Infantes, DavidCirurgia de l'obesitatTeixit adipósObesity surgeryAdipose tissuesINTRODUCTION: miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of BS on systemic metabolism. Here, we evaluated circulating levels of miR-92a and miR-99b, two miRNAs proposed as biomarkers of brown fat activity, in a cohort of patients with severe obesity before and after BS, and studied their potential relationship with BS-associated improvements in metabolic parameters. METHODS: Circulating levels of miR-92a and miR-99b were quantified in a cohort of 26 patients (age, 48 ± 10 years; BMI, 45 ± 7 kg/m2) before and 6 months after BS. Clinical parameters were determined at different time points and correlations among them were studied. RESULTS: Basal levels of miR-92a were significantly increased in patients with obesity relative to lean controls. Serum miR-92a levels were strongly reduced at 6 months after BS, reaching levels similar to those in controls. Serum miR-99b levels were unchanged in relation to both the obese condition and BS. Elevated levels of miR-92a were directly correlated with worsened glucose homeostasis parameters and poor BS outcome. CONCLUSIONS: Our findings show that miR-92a is elevated in conditions of obesity, and its reduction after BS correlates with metabolic improvement. Further studies would be necessary to establish miR-92a as serum biomarker and potential predictor of the BS success in improving the metabolic status of patients with obesity.Springer Verlag2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/218091Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1007/s11695-019-04104-yObesity Surgery, 2020, vol. 30, num.1, p. 174-179https://doi.org/10.1007/s11695-019-04104-y(c) Springer Verlag, 2020info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2180912026-05-27T06:46:51Z
dc.title.none.fl_str_mv Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
title Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
spellingShingle Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
Cereijo Téllez, Rubén
Cirurgia de l'obesitat
Teixit adipós
Obesity surgery
Adipose tissues
title_short Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
title_full Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
title_fullStr Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
title_full_unstemmed Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
title_sort Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
dc.creator.none.fl_str_mv Cereijo Téllez, Rubén
Taxerås, Siri D.
Piquer-Garcia, Irene
Pellitero, Silvia
Martínez Cáceres, Eva María
Tarascó, Jordi
Moreno, Pau
Balibrea, José
Puig-Domingo, Manel
Jiménez-Pavón, David
Lerin, Carles
Villarroya i Gombau, Francesc
Sánchez-Infantes, David
author Cereijo Téllez, Rubén
author_facet Cereijo Téllez, Rubén
Taxerås, Siri D.
Piquer-Garcia, Irene
Pellitero, Silvia
Martínez Cáceres, Eva María
Tarascó, Jordi
Moreno, Pau
Balibrea, José
Puig-Domingo, Manel
Jiménez-Pavón, David
Lerin, Carles
Villarroya i Gombau, Francesc
Sánchez-Infantes, David
author_role author
author2 Taxerås, Siri D.
Piquer-Garcia, Irene
Pellitero, Silvia
Martínez Cáceres, Eva María
Tarascó, Jordi
Moreno, Pau
Balibrea, José
Puig-Domingo, Manel
Jiménez-Pavón, David
Lerin, Carles
Villarroya i Gombau, Francesc
Sánchez-Infantes, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cirurgia de l'obesitat
Teixit adipós
Obesity surgery
Adipose tissues
topic Cirurgia de l'obesitat
Teixit adipós
Obesity surgery
Adipose tissues
description INTRODUCTION: miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of BS on systemic metabolism. Here, we evaluated circulating levels of miR-92a and miR-99b, two miRNAs proposed as biomarkers of brown fat activity, in a cohort of patients with severe obesity before and after BS, and studied their potential relationship with BS-associated improvements in metabolic parameters. METHODS: Circulating levels of miR-92a and miR-99b were quantified in a cohort of 26 patients (age, 48 ± 10 years; BMI, 45 ± 7 kg/m2) before and 6 months after BS. Clinical parameters were determined at different time points and correlations among them were studied. RESULTS: Basal levels of miR-92a were significantly increased in patients with obesity relative to lean controls. Serum miR-92a levels were strongly reduced at 6 months after BS, reaching levels similar to those in controls. Serum miR-99b levels were unchanged in relation to both the obese condition and BS. Elevated levels of miR-92a were directly correlated with worsened glucose homeostasis parameters and poor BS outcome. CONCLUSIONS: Our findings show that miR-92a is elevated in conditions of obesity, and its reduction after BS correlates with metabolic improvement. Further studies would be necessary to establish miR-92a as serum biomarker and potential predictor of the BS success in improving the metabolic status of patients with obesity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/218091
url https://hdl.handle.net/2445/218091
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/s11695-019-04104-y
Obesity Surgery, 2020, vol. 30, num.1, p. 174-179
https://doi.org/10.1007/s11695-019-04104-y
dc.rights.none.fl_str_mv (c) Springer Verlag, 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Verlag, 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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