Reliability of the ABC/2 Method in Determining Acute Infarct Volume

Background and Purpose: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infa...

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Autores: Pedraza, S., Puig Alcántara, Josep, Blasco Solà, Gerard, Daunis-i-Estadella, Pepus, Boada, Imma, Bardera i Reig, Antoni, Castellanos, María del Mar, Serena, Joaquín
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/11680
Acceso en línea:http://hdl.handle.net/10256/11680
Access Level:acceso embargado
Palabra clave:Isquèmia cerebral
Cerebral ischemia
Malalties cerebrovasculars
Cerebrovascular disease
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spelling Reliability of the ABC/2 Method in Determining Acute Infarct VolumePedraza, S.Puig Alcántara, JosepBlasco Solà, GerardDaunis-i-Estadella, PepusBoada, ImmaBardera i Reig, AntoniCastellanos, María del MarSerena, JoaquínIsquèmia cerebralCerebral ischemiaMalalties cerebrovascularsCerebrovascular diseaseBackground and Purpose: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. Methods: We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. Results: The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm 3 (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively. Conclusions: ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volumeThis work was supported in part by governments' grants: From MEC TIN2010-21089-C03-01 and from Fondo de Investigaciones Sanitarias (FIS) grant (reference PI09/00596)WileyMinisterio de Ciencia e Innovación (Espanya)infoinfo2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/11680http://hdl.handle.net/10256/11680© Journal of Neuroimaging, 2012, vol. 22, núm. 2, p. 155-159Articles publicats (D-IMA)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1552-6569.2011.00588.xinfo:eu-repo/semantics/altIdentifier/issn/1051-2284info:eu-repo/semantics/altIdentifier/issn/1051-2284info:eu-repo/semantics/altIdentifier/eissn/1552-6569info:eu-repo/grantAgreement/MICINN//TIN2010-21089-C03-01Tots els drets reservatsinfo:eu-repo/semantics/embargoedAccessoai:recercat.cat:10256/116802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Reliability of the ABC/2 Method in Determining Acute Infarct Volume
title Reliability of the ABC/2 Method in Determining Acute Infarct Volume
spellingShingle Reliability of the ABC/2 Method in Determining Acute Infarct Volume
Pedraza, S.
Isquèmia cerebral
Cerebral ischemia
Malalties cerebrovasculars
Cerebrovascular disease
title_short Reliability of the ABC/2 Method in Determining Acute Infarct Volume
title_full Reliability of the ABC/2 Method in Determining Acute Infarct Volume
title_fullStr Reliability of the ABC/2 Method in Determining Acute Infarct Volume
title_full_unstemmed Reliability of the ABC/2 Method in Determining Acute Infarct Volume
title_sort Reliability of the ABC/2 Method in Determining Acute Infarct Volume
dc.creator.none.fl_str_mv Pedraza, S.
Puig Alcántara, Josep
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Boada, Imma
Bardera i Reig, Antoni
Castellanos, María del Mar
Serena, Joaquín
author Pedraza, S.
author_facet Pedraza, S.
Puig Alcántara, Josep
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Boada, Imma
Bardera i Reig, Antoni
Castellanos, María del Mar
Serena, Joaquín
author_role author
author2 Puig Alcántara, Josep
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Boada, Imma
Bardera i Reig, Antoni
Castellanos, María del Mar
Serena, Joaquín
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (Espanya)
dc.subject.none.fl_str_mv Isquèmia cerebral
Cerebral ischemia
Malalties cerebrovasculars
Cerebrovascular disease
topic Isquèmia cerebral
Cerebral ischemia
Malalties cerebrovasculars
Cerebrovascular disease
description Background and Purpose: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. Methods: We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. Results: The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm 3 (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively. Conclusions: ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume
publishDate 2012
dc.date.none.fl_str_mv 2012
info
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/11680
http://hdl.handle.net/10256/11680
url http://hdl.handle.net/10256/11680
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1552-6569.2011.00588.x
info:eu-repo/semantics/altIdentifier/issn/1051-2284
info:eu-repo/semantics/altIdentifier/issn/1051-2284
info:eu-repo/semantics/altIdentifier/eissn/1552-6569
info:eu-repo/grantAgreement/MICINN//TIN2010-21089-C03-01
dc.rights.none.fl_str_mv Tots els drets reservats
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Tots els drets reservats
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv © Journal of Neuroimaging, 2012, vol. 22, núm. 2, p. 155-159
Articles publicats (D-IMA)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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