Peripheral amyloid levels present gender differences associated with aging in AβPP/PS1 mice
The accumulation of amyloid-β (Aβ) peptide is one of the major neuropathological hallmarks of Alzheimer's disease (AD). We have analyzed whether the progression of amyloidosis differentially affects males and females along aging in AβPP/PS1 transgenic mice. The levels of peripheral amyloid, Aβ4...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/124540 |
| Acceso en línea: | http://hdl.handle.net/10261/124540 |
| Access Level: | acceso abierto |
| Palabra clave: | Aging Transgenic mice Peripheral amyloid ABPP/PS1 Amyloid-beta Alzheimer’s disease models |
| Sumario: | The accumulation of amyloid-β (Aβ) peptide is one of the major neuropathological hallmarks of Alzheimer's disease (AD). We have analyzed whether the progression of amyloidosis differentially affects males and females along aging in AβPP/PS1 transgenic mice. The levels of peripheral amyloid, Aβ40 and Aβ42, are not modified in either sex until 9 months of age. After that, however, there is an increase in amyloid levels in plasma among females and a decrease among males. These findings could be essential to design gender-specific strategies in other in vivo experiments or even in AD treatments. Supplementary Figure 1. A) Percentage of the cases of AβPP/PS1 transgenic mice (males and females) that show bladder disturbances. In dark affected individuals, in grey no evidence of any disturbance. Image of a healthy bladder (B) and a swollen bladder (C). D) Western blot analysis of some biochemical markers in the mice brains; 6 and 15 months, male, female, transgenic and wild type. |
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