Association between PAI-1 4G/5G polymorphism and COVID-19 patients with different SARS-CoV-2 variants
[eng] Introduction: Previous studies revealed that plasma PAI-1 level increases during SARS-CoV-2 infection and as a result, the probability of coagulation abnormalities during the course of infection increases. To our knowledge, there is no scientific investigation that evaluates...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de las Islas Baleares |
| Repositorio: | Biblioteca Digital de les Illes Balears |
| OAI Identifier: | medicinaBalear:AJHS_Medicina_Balear_2024v39n1p071 |
| Acceso en línea: | http://ibdigital.uib.es/greenstone/sites/oai-site/collect/medicinaBalear/index/assoc/AJHS_Med/icina_Ba/lear_202/4v39n1p0/71.dir/AJHS_Medicina_Balear_2024v39n1p071.pdf http://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/AJHS_Medicina_Balear_2024v39n1p071 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Pandemic, 2020- Health Sciences Medicine |
| Sumario: | [eng] Introduction: Previous studies revealed that plasma PAI-1 level increases during SARS-CoV-2 infection and as a result, the probability of coagulation abnormalities during the course of infection increases. To our knowledge, there is no scientific investigation that evaluates the association between PAI-1 4G/5G polymorphism and SARS-CoV-2 variants of concern. Methods: Total number of 408 individuals were included in the study (204 control and 204 patients). PAI-1 gene 4G/5G (rs1799889 A>G) polymorphism were genotyped by PCR-RFLP. The Ct values of COVID-19 patients were recorded to analyze the association with PAI-1 4G/5G gene polymorphism and viral load. Results: The PAI-1 4G/4G, 4G/5G, and 5G/5G genotype frequencies were, 24.5%, 40.2% and 35.3% in cases versus 1%, 2% and 97% in controls, respectively. The 4G allele has significant distribution between Delta variant cases and control, but not for the Omicron variant. The distribution of PAI-1 4G/5G + 4G/4G and 5G/5G genotype frequencies were, 79% and 21% in the Delta variant versus 51% and 49% in the Omicron variant, respectively. Carriers of the 4G allele had higher viral loads and lower Ct values as well. Conclusion: Ct values in the distribution of PAI-1 4G/5G + 4G/4G and 5G/5G genotype frequencies were, 21 and 25 in the Delta variant versus 26 and 28 in the Omicron variant. |
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