A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease
Allergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unkno...
| Autores: | , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/72810 |
| Acceso en línea: | https://hdl.handle.net/10230/72810 http://dx.doi.org/10.1038/s41467-025-62632-x |
| Access Level: | acceso abierto |
| Palabra clave: | Inactivated vaccines Mucosal immunology Translational immunology |
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España |
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| dc.title.none.fl_str_mv |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| title |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| spellingShingle |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease Sevilla-Ortega, Carmen Inactivated vaccines Mucosal immunology Translational immunology |
| title_short |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| title_full |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| title_fullStr |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| title_full_unstemmed |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| title_sort |
A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease |
| dc.creator.none.fl_str_mv |
Sevilla-Ortega, Carmen Angelina, Alba Martín-Cruz, Leticia Pérez-Diego, Mario Maldonado, Angel Lavín, Begoña Marcos-Ramiro, Beatriz Pérez de Llano, Luis Gayá, Auba Real, Francisco X. Conejero, Laura Subiza, José Luis Palomares, Oscar |
| author |
Sevilla-Ortega, Carmen |
| author_facet |
Sevilla-Ortega, Carmen Angelina, Alba Martín-Cruz, Leticia Pérez-Diego, Mario Maldonado, Angel Lavín, Begoña Marcos-Ramiro, Beatriz Pérez de Llano, Luis Gayá, Auba Real, Francisco X. Conejero, Laura Subiza, José Luis Palomares, Oscar |
| author_role |
author |
| author2 |
Angelina, Alba Martín-Cruz, Leticia Pérez-Diego, Mario Maldonado, Angel Lavín, Begoña Marcos-Ramiro, Beatriz Pérez de Llano, Luis Gayá, Auba Real, Francisco X. Conejero, Laura Subiza, José Luis Palomares, Oscar |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Inactivated vaccines Mucosal immunology Translational immunology |
| topic |
Inactivated vaccines Mucosal immunology Translational immunology |
| description |
Allergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unknown. Here we show MV130 prevents house dust mite (HDM)-induced local type 2 immune responses and associated eosinophilic airway inflammation, conferring protection up to 9 weeks after vaccination. MV130 reduces pathophysiological and clinical asthma features in an in vivo experimental mouse model of HDM-induced allergic eosinophilic asthma, restoring normal airway functionality. MV130 impairs allergen-specific IgE sensitization and systemic type 2 inflammation endorsing type 1 and IL-10 responses. In human DCs, MV130 induces a transcriptomic and metabolic reprogramming, and restores non-pathological immune responses to allergens in healthy and asthmatic donors. Additionally, the adoptive transfer of MV130-stimulated BMDCs was sufficient to reproduce the protective features of the vaccine administration in vivo. Collectively, we show MV130 reduces allergic sensitization and eosinophilic asthma. Our findings support the exploration of mucosal interventions aimed at reducing the risk of allergen-induced asthma development. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2026 2026 2026 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10230/72810 http://dx.doi.org/10.1038/s41467-025-62632-x https://hdl.handle.net/10230/72810 |
| url |
https://hdl.handle.net/10230/72810 http://dx.doi.org/10.1038/s41467-025-62632-x |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Nature Communications. 2025;16(1):7129 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Nature Research |
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Nature Research |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway diseaseSevilla-Ortega, CarmenAngelina, AlbaMartín-Cruz, LeticiaPérez-Diego, MarioMaldonado, AngelLavín, BegoñaMarcos-Ramiro, BeatrizPérez de Llano, LuisGayá, AubaReal, Francisco X.Conejero, LauraSubiza, José LuisPalomares, OscarInactivated vaccinesMucosal immunologyTranslational immunologyAllergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unknown. Here we show MV130 prevents house dust mite (HDM)-induced local type 2 immune responses and associated eosinophilic airway inflammation, conferring protection up to 9 weeks after vaccination. MV130 reduces pathophysiological and clinical asthma features in an in vivo experimental mouse model of HDM-induced allergic eosinophilic asthma, restoring normal airway functionality. MV130 impairs allergen-specific IgE sensitization and systemic type 2 inflammation endorsing type 1 and IL-10 responses. In human DCs, MV130 induces a transcriptomic and metabolic reprogramming, and restores non-pathological immune responses to allergens in healthy and asthmatic donors. Additionally, the adoptive transfer of MV130-stimulated BMDCs was sufficient to reproduce the protective features of the vaccine administration in vivo. Collectively, we show MV130 reduces allergic sensitization and eosinophilic asthma. Our findings support the exploration of mucosal interventions aimed at reducing the risk of allergen-induced asthma development.This work was supported by grant IND2019/BMD17182 to O.P. from the Industrial Doctoral Program (UCM-Inmunotek S.L) from Comunidad Autónoma de Madrid (CAM). C.S.-O. was contracted with this grant by Inmunotek SL to perform her Doctoral Thesis in UCM. O.P. laboratory is also supported by grant PID2020-114396RB-I00 from MICINN, Spain. Work in the lab of F.X.R. was supported, in part, by grant PID2021-128125OB-I00 from Ministerio de Ciencia, Innovación y Universidades (Madrid, Spain) (co-funded by the ERDF-EU). CNIO is supported by Ministerio de Ciencia, Innovación y Universidades as a Centro de Excelencia Severo Ochoa SEV-2015-0510." A.G. is recipient of a predoctoral fellowship from AECC.Nature Research2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72810http://dx.doi.org/10.1038/s41467-025-62632-xhttps://hdl.handle.net/10230/72810reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNature Communications. 2025;16(1):7129© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/728102026-05-29T05:05:01Z |
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