COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?

6 pages, 1 figure, 1 table PMID: 20333781 [PubMed]PMCID: PMC2846246

Bibliographic Details
Authors: Martín-Sanz, Paloma, Mayoral, Rafael, Casado, Marta, Boscá, Lisardo
Format: article
Publication Date:2010
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/25712
Online Access:http://hdl.handle.net/10261/25712
Access Level:Open access
Keyword:Cyclooxygenase 2
Prostaglandins
Liver diseases
Apoptosis
Inflammation
Animal models
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spelling COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?Martín-Sanz, PalomaMayoral, RafaelCasado, MartaBoscá, LisardoCyclooxygenase 2ProstaglandinsLiver diseasesApoptosisInflammationAnimal models6 pages, 1 figure, 1 table PMID: 20333781 [PubMed]PMCID: PMC2846246The use of animals lacking genes or expressing genes under the control of cell-specific promoters has significantly increased our knowledge of the genetic and molecular basis of physiopathology, allowing testing of functional hypotheses and validation of biochemical and pharmacologic approaches in order to understand cell function. However, with unexpected frequency, gene knockout animals and, more commonly, animal models of transgenesis give experimental support to even opposite conclusions on gene function. Here we summarize what we learned on the role of cyclooxygenase 2 (COX-2) in liver and revise the results obtained in 3 independent models of mice expressing a COX-2 transgene specifically in the hepatocyte. Upon challenge with pro-inflammatory stimuli, the animals behave very differently, some transgenic models having a protective effect but others enhancing the injury. In addition, one transgene exerts differential effects on normal liver physiology depending on the transgenic animal model used.Supported by Grant BFU2008-02161 and SAF2007-60551 from MICINN, S-BIO-0283/2006 from Comunidad de Madrid and FIS-RECAVA RD06/0014/0025. RECAVA and CIBERehd are funded by the Instituto de Salud Carlos IIIPeer reviewedBaishideng Publishing Group201020102010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501695037 bytesapplication/pdfhttp://hdl.handle.net/10261/25712reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3748/wjg.v16.i12.1430info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/257122026-05-22T06:33:51Z
dc.title.none.fl_str_mv COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
title COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
spellingShingle COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
Martín-Sanz, Paloma
Cyclooxygenase 2
Prostaglandins
Liver diseases
Apoptosis
Inflammation
Animal models
title_short COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
title_full COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
title_fullStr COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
title_full_unstemmed COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
title_sort COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
dc.creator.none.fl_str_mv Martín-Sanz, Paloma
Mayoral, Rafael
Casado, Marta
Boscá, Lisardo
author Martín-Sanz, Paloma
author_facet Martín-Sanz, Paloma
Mayoral, Rafael
Casado, Marta
Boscá, Lisardo
author_role author
author2 Mayoral, Rafael
Casado, Marta
Boscá, Lisardo
author2_role author
author
author
dc.subject.none.fl_str_mv Cyclooxygenase 2
Prostaglandins
Liver diseases
Apoptosis
Inflammation
Animal models
topic Cyclooxygenase 2
Prostaglandins
Liver diseases
Apoptosis
Inflammation
Animal models
description 6 pages, 1 figure, 1 table PMID: 20333781 [PubMed]PMCID: PMC2846246
publishDate 2010
dc.date.none.fl_str_mv 2010
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/25712
url http://hdl.handle.net/10261/25712
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3748/wjg.v16.i12.1430
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 695037 bytes
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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