Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz

11 páginas, 7 figuras, 2 tablas.

Detalhes bibliográficos
Autores: Ruiz, Mario, Sánchez, Diego, Canal, Inmaculada, Acebes-Vindel, José Ángel, Ganfornina, M. D.
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2011
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/49375
Acesso em linha:http://hdl.handle.net/10261/49375
Access Level:Acceso aberto
Palavra-chave:ApoD
Lazarillo
Lifespan
Aging
Reproduction
Stress-response
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spelling Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLazRuiz, MarioSánchez, DiegoCanal, InmaculadaAcebes-Vindel, José ÁngelGanfornina, M. D.ApoDLazarilloLifespanAgingReproductionStress-response11 páginas, 7 figuras, 2 tablas.Apolipoprotein D (ApoD), a member of the Lipocalin family, is the gene most up-regulated with age in the mammalian brain. Its expression strongly correlates with aging-associated neurodegenerative and metabolic diseases. Two homologues of ApoD expressed in the Drosophila brain, Glial Lazarillo (GLaz) and Neural Lazarillo (NLaz), are known to alter longevity in male flies. However, sex differences in the aging process have not been explored so far for these genes. Here we demonstrate that NLaz alters lifespan in both sexes, but unexpectedly the lack of GLaz influences longevity in a sex-specific way, reducing longevity in males but not in females. While NLaz has metabolic functions similar to ApoD, the regulation of GLaz expression upon aging is the closest to ApoD in the aging brain. A multivariate analysis of physiological parameters relevant to lifespan modulation uncovers both common and specialized functions for the two Lipocalins, and reveals that changes in protein homeostasis account for the observed sex-specific patterns of longevity. The response to oxidative stress and accumulation of lipid peroxides are among their common functions, while the transcriptional and behavioral response to starvation, the pattern of daily locomotor activity, storage of fat along aging, fertility, and courtship behavior differentiate NLaz from GLaz mutants. We also demonstrate that food composition is an important environmental parameter influencing stress resistance and reproductive phenotypes of both Lipocalin mutants. Since ApoD shares many properties with the common ancestor of invertebrate Lipocalins, we must benefit from this global comparison with both GLaz and NLaz to understand the complex functions of ApoD in mammalian aging and neurodegeneration.This work was supported by start-up grants to D.S. and M.D.G. from the “Ramón y Cajal Program” (Ministerio de Ciencia y Tecnología—Spain, and Fondo Europeo de Desarrollo Regional SGFRH Foundation; Junta de Castilla y Leon grant VA049A0, Ministerio de Educacion y Ciencia grant BFU2005-00522, and Ministerio de Ciencia e Innovacion grant BFU2008-01170 to M.D.G. and D.S.; Ministerio de Ciencia e Innovacion grant BFU2008-04683-C02-02 to I.C.; Ministerio de Ciencia e Innovacion grant BFU2009-12410/BMC and Fundación Cien Reina Sofía to A.A.Peer reviewedElsevierMinisterio de Ciencia y Tecnología (España)Ministerio de Educación y Ciencia (España)European CommissionSan Francisco General Hospital FoundationInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220122011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/49375reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.exger.2011.02.014Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/493752026-05-22T06:33:51Z
dc.title.none.fl_str_mv Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
title Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
spellingShingle Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
Ruiz, Mario
ApoD
Lazarillo
Lifespan
Aging
Reproduction
Stress-response
title_short Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
title_full Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
title_fullStr Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
title_full_unstemmed Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
title_sort Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
dc.creator.none.fl_str_mv Ruiz, Mario
Sánchez, Diego
Canal, Inmaculada
Acebes-Vindel, José Ángel
Ganfornina, M. D.
author Ruiz, Mario
author_facet Ruiz, Mario
Sánchez, Diego
Canal, Inmaculada
Acebes-Vindel, José Ángel
Ganfornina, M. D.
author_role author
author2 Sánchez, Diego
Canal, Inmaculada
Acebes-Vindel, José Ángel
Ganfornina, M. D.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia y Tecnología (España)
Ministerio de Educación y Ciencia (España)
European Commission
San Francisco General Hospital Foundation
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv ApoD
Lazarillo
Lifespan
Aging
Reproduction
Stress-response
topic ApoD
Lazarillo
Lifespan
Aging
Reproduction
Stress-response
description 11 páginas, 7 figuras, 2 tablas.
publishDate 2011
dc.date.none.fl_str_mv 2011
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/49375
url http://hdl.handle.net/10261/49375
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.exger.2011.02.014
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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