New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood

Chronic administration of a high-fat diet in mice has been established to influence the generation and trafficking of immune cells such as neutrophils in the bone marrow, the dysregulation of which may contribute to a wide range of diseases. However, no studies have tested the hypothesis that a shor...

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Authors: Ortega Gómez, Almudena, López Martín, Sergio, Varela Pérez, Lourdes María, Jaramillo Carmona, Sara, García Muriana, Francisco José, Abia González, María del Rocío
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/137516
Online Access:https://hdl.handle.net/11441/137516
https://doi.org/10.1016/j.fochms.2022.100133
Access Level:Open access
Keyword:Olive oil
Butter
Dietary fatty acids
High-fat diets
Neutrophil mobilisation
Bone marrow inflammation
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spelling New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral bloodOrtega Gómez, AlmudenaLópez Martín, SergioVarela Pérez, Lourdes MaríaJaramillo Carmona, SaraGarcía Muriana, Francisco JoséAbia González, María del RocíoOlive oilButterDietary fatty acidsHigh-fat dietsNeutrophil mobilisationBone marrow inflammationChronic administration of a high-fat diet in mice has been established to influence the generation and trafficking of immune cells such as neutrophils in the bone marrow, the dysregulation of which may contribute to a wide range of diseases. However, no studies have tested the hypothesis that a short-term, high-fat diet could early modulate the neutrophil release from bone marrow at fasting and at postprandial in response to a high-fat meal challenge, and that the predominant type of fatty acids in dietary fats could play a role in both context conditions. Based on these premises, we aimed to establish the effects of different fats [butter, enriched in saturated fatty acids (SFAs), olive oil, enriched in monounsaturated fatty acids (MUFAs), and olive oil supplemented with eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids] on neutrophil navigation from bone marrow to blood in mice. The analysis of cellular models for mechanistic understanding and of postprandial blood samples from healthy volunteers for translational purposes was assessed. The results revealed a powerful effect of dietary SFAs in promotion the neutrophil traffic from bone marrow to blood via the CXCL2-CXCR2 axis. Dietary SFAs, but not MUFAs or EPA and DHA, were also associated with increased neutrophil apoptosis and bone marrow inflammation. Similar dietary fatty-acid-induced postprandial neutrophilia was observed in otherwise healthy humans. Therefore, dietary MUFAs might preserve bone marrow health and proper migration of bone marrow neutrophils early in the course of high-fat diets even after the intake of high-fat meals.ElsevierBiología Celular2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/137516https://doi.org/10.1016/j.fochms.2022.100133reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFood Chemistry: Molecular Sciences, 5, 100133.https://dx.doi.org/10.1016/j.fochms.2022.100133info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1375162026-06-17T12:51:07Z
dc.title.none.fl_str_mv New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
title New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
spellingShingle New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
Ortega Gómez, Almudena
Olive oil
Butter
Dietary fatty acids
High-fat diets
Neutrophil mobilisation
Bone marrow inflammation
title_short New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
title_full New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
title_fullStr New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
title_full_unstemmed New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
title_sort New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
dc.creator.none.fl_str_mv Ortega Gómez, Almudena
López Martín, Sergio
Varela Pérez, Lourdes María
Jaramillo Carmona, Sara
García Muriana, Francisco José
Abia González, María del Rocío
author Ortega Gómez, Almudena
author_facet Ortega Gómez, Almudena
López Martín, Sergio
Varela Pérez, Lourdes María
Jaramillo Carmona, Sara
García Muriana, Francisco José
Abia González, María del Rocío
author_role author
author2 López Martín, Sergio
Varela Pérez, Lourdes María
Jaramillo Carmona, Sara
García Muriana, Francisco José
Abia González, María del Rocío
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Biología Celular
dc.subject.none.fl_str_mv Olive oil
Butter
Dietary fatty acids
High-fat diets
Neutrophil mobilisation
Bone marrow inflammation
topic Olive oil
Butter
Dietary fatty acids
High-fat diets
Neutrophil mobilisation
Bone marrow inflammation
description Chronic administration of a high-fat diet in mice has been established to influence the generation and trafficking of immune cells such as neutrophils in the bone marrow, the dysregulation of which may contribute to a wide range of diseases. However, no studies have tested the hypothesis that a short-term, high-fat diet could early modulate the neutrophil release from bone marrow at fasting and at postprandial in response to a high-fat meal challenge, and that the predominant type of fatty acids in dietary fats could play a role in both context conditions. Based on these premises, we aimed to establish the effects of different fats [butter, enriched in saturated fatty acids (SFAs), olive oil, enriched in monounsaturated fatty acids (MUFAs), and olive oil supplemented with eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids] on neutrophil navigation from bone marrow to blood in mice. The analysis of cellular models for mechanistic understanding and of postprandial blood samples from healthy volunteers for translational purposes was assessed. The results revealed a powerful effect of dietary SFAs in promotion the neutrophil traffic from bone marrow to blood via the CXCL2-CXCR2 axis. Dietary SFAs, but not MUFAs or EPA and DHA, were also associated with increased neutrophil apoptosis and bone marrow inflammation. Similar dietary fatty-acid-induced postprandial neutrophilia was observed in otherwise healthy humans. Therefore, dietary MUFAs might preserve bone marrow health and proper migration of bone marrow neutrophils early in the course of high-fat diets even after the intake of high-fat meals.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/137516
https://doi.org/10.1016/j.fochms.2022.100133
url https://hdl.handle.net/11441/137516
https://doi.org/10.1016/j.fochms.2022.100133
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Food Chemistry: Molecular Sciences, 5, 100133.
https://dx.doi.org/10.1016/j.fochms.2022.100133
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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