Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may...

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Autores: Zirak, P, Gregori-Pla, C, Blanco, I, Fortuna, A, Cotta, G, Bramon, P, Serra, I, Mola, A, Sola-Soler, J, Giraldo-Giraldo, BF, Durduran, T, Mayos, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p3308
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3308
http://ddd.uab.cat/record/226326
Access Level:acceso abierto
Palabra clave:sleep disorder breathing
cerebral blood flow
brain perfusion
diffuse correlation spectroscopy
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spelling Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleepZirak, PGregori-Pla, CBlanco, IFortuna, ACotta, GBramon, PSerra, IMola, ASola-Soler, JGiraldo-Giraldo, BFDurduran, TMayos, Msleep disorder breathingcerebral blood flowbrain perfusiondiffuse correlation spectroscopyObstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age 58 +/- 8 years, 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of 83 +/- 15 apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF (30 +/- 17%) at the end of the event followed by a drop (-20 +/- 12%) similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations. (c) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3308http://ddd.uab.cat/record/226326NeurophotonicsISSN: 2329423XISSNe: 23294248reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p33082026-06-14T12:41:47Z
dc.title.none.fl_str_mv Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
spellingShingle Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
Zirak, P
sleep disorder breathing
cerebral blood flow
brain perfusion
diffuse correlation spectroscopy
title_short Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_full Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_fullStr Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_full_unstemmed Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_sort Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
dc.creator.none.fl_str_mv Zirak, P
Gregori-Pla, C
Blanco, I
Fortuna, A
Cotta, G
Bramon, P
Serra, I
Mola, A
Sola-Soler, J
Giraldo-Giraldo, BF
Durduran, T
Mayos, M
author Zirak, P
author_facet Zirak, P
Gregori-Pla, C
Blanco, I
Fortuna, A
Cotta, G
Bramon, P
Serra, I
Mola, A
Sola-Soler, J
Giraldo-Giraldo, BF
Durduran, T
Mayos, M
author_role author
author2 Gregori-Pla, C
Blanco, I
Fortuna, A
Cotta, G
Bramon, P
Serra, I
Mola, A
Sola-Soler, J
Giraldo-Giraldo, BF
Durduran, T
Mayos, M
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv sleep disorder breathing
cerebral blood flow
brain perfusion
diffuse correlation spectroscopy
topic sleep disorder breathing
cerebral blood flow
brain perfusion
diffuse correlation spectroscopy
description Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age 58 +/- 8 years, 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of 83 +/- 15 apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF (30 +/- 17%) at the end of the event followed by a drop (-20 +/- 12%) similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations. (c) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3308
http://ddd.uab.cat/record/226326
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3308
http://ddd.uab.cat/record/226326
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
publisher.none.fl_str_mv SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
dc.source.none.fl_str_mv Neurophotonics
ISSN: 2329423X
ISSNe: 23294248
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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