First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

Most previous longitudinal studies of functional magnetic resonance imaging (fMRI) in first-episode psychosis (FEP) using cognitive paradigm task found an increased activation after antipsychotic medications. We designed an emotional auditory paradigm to explore brain activation during emotional and...

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Autores: Gonzalez-Vivas, C, Garcia-Marti, G, Soldevila-Matias, P, Sanz-Requena, R, Aguilar, EJ, Castro-Bleda, MJ, Marti-Bonmati, L, Sanjuan, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15401
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15401
https://roderic.uv.es/handle/10550/79103
Access Level:acceso abierto
Palabra clave:first episode psychosis (FEP)
fMRI&#8212
functional magnetic resonance imaging
longitudinal
emotional design model
paradigm
follow up
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spelling First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory ParadigmGonzalez-Vivas, CGarcia-Marti, GSoldevila-Matias, PSanz-Requena, RAguilar, EJCastro-Bleda, MJMarti-Bonmati, LSanjuan, Jfirst episode psychosis (FEP)fMRI&#8212functional magnetic resonance imaginglongitudinalemotional design modelparadigmfollow upMost previous longitudinal studies of functional magnetic resonance imaging (fMRI) in first-episode psychosis (FEP) using cognitive paradigm task found an increased activation after antipsychotic medications. We designed an emotional auditory paradigm to explore brain activation during emotional and nonemotional word processing. This study aimed to analyze if longitudinal changes in brain fMRI BOLD activation is present in patients vs. healthy controls. A group of FEP patients (n = 34) received clinical assessment and had a fMRI scan at baseline and follow-up (average, 25-month interval). During the fMRI scan, both emotional and nonemotional words were presented as a block design. Results were compared with a pair of healthy control group (n = 13). Patients showed a decreased activation at follow-up fMRI in amygdala (F = 4.69; p = 0.04) and hippocampus (F = 5.03; p = 0.03) compared with controls. Middle frontal gyrus was the only area that showed a substantial increased activation in patients (F = 4.53; p = 0.04). A great heterogeneity in individual activation patterns was also found. These results support the relevance of the type of paradigm in neuroimaging for psychosis. This is, as far as we know, the first longitudinal study with an emotional auditory paradigm in FEP. Our results suggested that the amygdala and hippocampus play a key role in psychotic disease. More studies are needed to understand the heterogeneity of response at individual level.FRONTIERS MEDIA SA2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15401https://roderic.uv.es/handle/10550/79103Frontiers in PsychiatryISSN: 16640640reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p154012026-06-07T16:35:31Z
dc.title.none.fl_str_mv First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
title First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
spellingShingle First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
Gonzalez-Vivas, C
first episode psychosis (FEP)
fMRI&#8212
functional magnetic resonance imaging
longitudinal
emotional design model
paradigm
follow up
title_short First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
title_full First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
title_fullStr First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
title_full_unstemmed First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
title_sort First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
dc.creator.none.fl_str_mv Gonzalez-Vivas, C
Garcia-Marti, G
Soldevila-Matias, P
Sanz-Requena, R
Aguilar, EJ
Castro-Bleda, MJ
Marti-Bonmati, L
Sanjuan, J
author Gonzalez-Vivas, C
author_facet Gonzalez-Vivas, C
Garcia-Marti, G
Soldevila-Matias, P
Sanz-Requena, R
Aguilar, EJ
Castro-Bleda, MJ
Marti-Bonmati, L
Sanjuan, J
author_role author
author2 Garcia-Marti, G
Soldevila-Matias, P
Sanz-Requena, R
Aguilar, EJ
Castro-Bleda, MJ
Marti-Bonmati, L
Sanjuan, J
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv first episode psychosis (FEP)
fMRI&#8212
functional magnetic resonance imaging
longitudinal
emotional design model
paradigm
follow up
topic first episode psychosis (FEP)
fMRI&#8212
functional magnetic resonance imaging
longitudinal
emotional design model
paradigm
follow up
description Most previous longitudinal studies of functional magnetic resonance imaging (fMRI) in first-episode psychosis (FEP) using cognitive paradigm task found an increased activation after antipsychotic medications. We designed an emotional auditory paradigm to explore brain activation during emotional and nonemotional word processing. This study aimed to analyze if longitudinal changes in brain fMRI BOLD activation is present in patients vs. healthy controls. A group of FEP patients (n = 34) received clinical assessment and had a fMRI scan at baseline and follow-up (average, 25-month interval). During the fMRI scan, both emotional and nonemotional words were presented as a block design. Results were compared with a pair of healthy control group (n = 13). Patients showed a decreased activation at follow-up fMRI in amygdala (F = 4.69; p = 0.04) and hippocampus (F = 5.03; p = 0.03) compared with controls. Middle frontal gyrus was the only area that showed a substantial increased activation in patients (F = 4.53; p = 0.04). A great heterogeneity in individual activation patterns was also found. These results support the relevance of the type of paradigm in neuroimaging for psychosis. This is, as far as we know, the first longitudinal study with an emotional auditory paradigm in FEP. Our results suggested that the amygdala and hippocampus play a key role in psychotic disease. More studies are needed to understand the heterogeneity of response at individual level.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15401
https://roderic.uv.es/handle/10550/79103
url https://incliva.portalinvestigacion.com/publicaciones/15401
https://roderic.uv.es/handle/10550/79103
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Psychiatry
ISSN: 16640640
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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