Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study

Background: Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci i...

Descripción completa

Detalles Bibliográficos
Autores: Berasategui, Barbara, Fonollosa, Alex, Artaraz, Joseba, Ruiz Arruza, Ioana, Ríos, José, Matas, Jessica, Llorenç, Victor, Díaz Valle, David, Sastre Ibanez, Marina, Arriola Villalobos, Pedro, Adán Civera, Alfredo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/132624
Acceso en línea:https://hdl.handle.net/2445/132624
Access Level:acceso abierto
Palabra clave:Micròglia
Oftalmopaties
Malalties de la retina
Pronòstic mèdic
Microglia
Ophthalmopathies
Retinal diseases
Prognosis
id ES_c19b457446c719c013563515f29c91c8
oai_identifier_str oai:diposit.ub.edu:2445/132624
network_acronym_str ES
network_name_str España
repository_id_str
spelling Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective studyBerasategui, BarbaraFonollosa, AlexArtaraz, JosebaRuiz Arruza, IoanaRíos, JoséMatas, JessicaLlorenç, VictorDíaz Valle, DavidSastre Ibanez, MarinaArriola Villalobos, PedroAdán Civera, AlfredoMicrògliaOftalmopatiesMalalties de la retinaPronòstic mèdicMicrogliaOphthalmopathiesRetinal diseasesPrognosisBackground: Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci in patients with non-infectious uveitic macular edema and evaluate their behavior after treatment. Methods: We conducted a multicenter, prospective, observational, 12-month follow-up study. Inclusion criteria were age > 18 years and a diagnosis of non-infectious uveitic macular edema, defined as central macular thickness of > 300 mu m as measured by OCT and fluid in the macula. Collected data included best corrected visual acuity, central macular thickness and the presence, number and distribution (inner or outer retinal layers) of hyperreflective foci. Evaluations were performed at baseline, and at 1, 3, 6, and 12 months after starting treatment. Results: We included 24 eyes of 24 patients. The frequency of patients with >= 11 hyperreflective foci was 58.4% at baseline, falling to 20.8% at 12 months. Further, hyperreflective foci were observed in the outer retinal layers in 50% of patients at baseline and just 28.6% at 12 months. Mean LogMAR visual acuity improved from 0.55 (95% CI 0.4-0. 71) at baseline to 0.22 (95% CI 0.08-0.35) at 12 months (p < 0.001). Mean central macular thickness decreased from 453.83 mu m (95% CI 396.6-511) at baseline to 269.32 mu m (95% CI 227.7-310.9) at 12 months (P < 0.001). Central macular thickness was associated with number (p = 0.017) and distribution (p = 0.004) of hyperreflective foci. Conclusions: We have observed hyperreflective foci in most of our patients with non-infectious uveitic macular edema. During follow-up and after treatment, the number of foci diminished and they tended to be located in the inner layers of the retina.BioMed Central2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/132624Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s12886-018-0848-5BMC Ophthalmology, 2018, vol. 18, num. 1, p. 179-188https://doi.org/10.1186/s12886-018-0848-5cc-by (c) Berasategui, Barbara et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1326242026-05-27T06:46:51Z
dc.title.none.fl_str_mv Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
title Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
spellingShingle Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
Berasategui, Barbara
Micròglia
Oftalmopaties
Malalties de la retina
Pronòstic mèdic
Microglia
Ophthalmopathies
Retinal diseases
Prognosis
title_short Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
title_full Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
title_fullStr Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
title_full_unstemmed Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
title_sort Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
dc.creator.none.fl_str_mv Berasategui, Barbara
Fonollosa, Alex
Artaraz, Joseba
Ruiz Arruza, Ioana
Ríos, José
Matas, Jessica
Llorenç, Victor
Díaz Valle, David
Sastre Ibanez, Marina
Arriola Villalobos, Pedro
Adán Civera, Alfredo
author Berasategui, Barbara
author_facet Berasategui, Barbara
Fonollosa, Alex
Artaraz, Joseba
Ruiz Arruza, Ioana
Ríos, José
Matas, Jessica
Llorenç, Victor
Díaz Valle, David
Sastre Ibanez, Marina
Arriola Villalobos, Pedro
Adán Civera, Alfredo
author_role author
author2 Fonollosa, Alex
Artaraz, Joseba
Ruiz Arruza, Ioana
Ríos, José
Matas, Jessica
Llorenç, Victor
Díaz Valle, David
Sastre Ibanez, Marina
Arriola Villalobos, Pedro
Adán Civera, Alfredo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Micròglia
Oftalmopaties
Malalties de la retina
Pronòstic mèdic
Microglia
Ophthalmopathies
Retinal diseases
Prognosis
topic Micròglia
Oftalmopaties
Malalties de la retina
Pronòstic mèdic
Microglia
Ophthalmopathies
Retinal diseases
Prognosis
description Background: Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci in patients with non-infectious uveitic macular edema and evaluate their behavior after treatment. Methods: We conducted a multicenter, prospective, observational, 12-month follow-up study. Inclusion criteria were age > 18 years and a diagnosis of non-infectious uveitic macular edema, defined as central macular thickness of > 300 mu m as measured by OCT and fluid in the macula. Collected data included best corrected visual acuity, central macular thickness and the presence, number and distribution (inner or outer retinal layers) of hyperreflective foci. Evaluations were performed at baseline, and at 1, 3, 6, and 12 months after starting treatment. Results: We included 24 eyes of 24 patients. The frequency of patients with >= 11 hyperreflective foci was 58.4% at baseline, falling to 20.8% at 12 months. Further, hyperreflective foci were observed in the outer retinal layers in 50% of patients at baseline and just 28.6% at 12 months. Mean LogMAR visual acuity improved from 0.55 (95% CI 0.4-0. 71) at baseline to 0.22 (95% CI 0.08-0.35) at 12 months (p < 0.001). Mean central macular thickness decreased from 453.83 mu m (95% CI 396.6-511) at baseline to 269.32 mu m (95% CI 227.7-310.9) at 12 months (P < 0.001). Central macular thickness was associated with number (p = 0.017) and distribution (p = 0.004) of hyperreflective foci. Conclusions: We have observed hyperreflective foci in most of our patients with non-infectious uveitic macular edema. During follow-up and after treatment, the number of foci diminished and they tended to be located in the inner layers of the retina.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/132624
url https://hdl.handle.net/2445/132624
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12886-018-0848-5
BMC Ophthalmology, 2018, vol. 18, num. 1, p. 179-188
https://doi.org/10.1186/s12886-018-0848-5
dc.rights.none.fl_str_mv cc-by (c) Berasategui, Barbara et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Berasategui, Barbara et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418573752958976
score 15,301603

Similares en LA Referencia