Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.

Single-cell RNA sequencing (scRNA-seq) technology has emerged as a powerful tool for dissecting cellular heterogeneity and understanding the intricate biology of diseases, including cancer. Endometrial cancer (EC) stands out as the most prevalent gynecological malignancy in Europe and the second mos...

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Autores: Pérez-Mies, Belén, Cortés, Belén, Palacios, José, González-Martínez, Silvia|||/items/a6747706-be4e-48c8-b8a5-32737469f700
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Alfonso X el Sabio
Repositorio:Repositorio Institucional de la Universidad Alfonso X el Sabio
Idioma:inglés
OAI Identifier:oai:archive.uax.com:20.500.12080/54908
Acceso en línea:https://hdl.handle.net/20.500.12080/54908
Access Level:acceso abierto
Palabra clave:Secuenciación de ARN unicelular
Cáncer de endometrio
Microambiente tumoral
Panorama inmunitario
Heterogeneidad celular
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spelling Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.Pérez-Mies, BelénCortés, BelénPalacios, JoséGonzález-Martínez, Silvia|||/items/a6747706-be4e-48c8-b8a5-32737469f700Secuenciación de ARN unicelularCáncer de endometrioMicroambiente tumoralPanorama inmunitarioHeterogeneidad celularSingle-cell RNA sequencing (scRNA-seq) technology has emerged as a powerful tool for dissecting cellular heterogeneity and understanding the intricate biology of diseases, including cancer. Endometrial cancer (EC) stands out as the most prevalent gynecological malignancy in Europe and the second most diagnosed worldwide, yet its cellular complexity remains poorly understood. In this review, we explore the contributions of scRNA-seq studies to shed light on the tumor cells and cellular landscape of EC. We discuss the diverse tumoral and microenvironmental populations identified through scRNA-seq, highlighting the implications for understanding disease progression. Furthermore, we address potential limitations inherent in scRNA-seq studies, such as technical biases and sample size constraints, emphasizing the need for larger-scale research encompassing a broader spectrum of EC histological subtypes. Notably, a significant proportion of scRNA-seq analyses have focused on primary endometrioid carcinoma tumors, underscoring the need to incorporate additional histological and aggressive types to comprehensively capture the heterogeneity of EC. By critically evaluating the current state of scRNA-seq research in EC, this review underscores the importance of advancing towards more comprehensive studies to accelerate our understanding of this complex disease.FrontiersUAX -Campus MadridUAX Archive20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12080/54908reponame:Repositorio Institucional de la Universidad Alfonso X el Sabioinstname:Universidad Alfonso X el SabioInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:archive.uax.com:20.500.12080/549082026-05-28T12:40:21Z
dc.title.none.fl_str_mv Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
title Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
spellingShingle Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
Pérez-Mies, Belén
Secuenciación de ARN unicelular
Cáncer de endometrio
Microambiente tumoral
Panorama inmunitario
Heterogeneidad celular
title_short Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
title_full Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
title_fullStr Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
title_full_unstemmed Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
title_sort Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.
dc.creator.none.fl_str_mv Pérez-Mies, Belén
Cortés, Belén
Palacios, José
González-Martínez, Silvia|||/items/a6747706-be4e-48c8-b8a5-32737469f700
author Pérez-Mies, Belén
author_facet Pérez-Mies, Belén
Cortés, Belén
Palacios, José
González-Martínez, Silvia|||/items/a6747706-be4e-48c8-b8a5-32737469f700
author_role author
author2 Cortés, Belén
Palacios, José
González-Martínez, Silvia|||/items/a6747706-be4e-48c8-b8a5-32737469f700
author2_role author
author
author
dc.contributor.none.fl_str_mv UAX -Campus Madrid
UAX Archive
dc.subject.none.fl_str_mv Secuenciación de ARN unicelular
Cáncer de endometrio
Microambiente tumoral
Panorama inmunitario
Heterogeneidad celular
topic Secuenciación de ARN unicelular
Cáncer de endometrio
Microambiente tumoral
Panorama inmunitario
Heterogeneidad celular
description Single-cell RNA sequencing (scRNA-seq) technology has emerged as a powerful tool for dissecting cellular heterogeneity and understanding the intricate biology of diseases, including cancer. Endometrial cancer (EC) stands out as the most prevalent gynecological malignancy in Europe and the second most diagnosed worldwide, yet its cellular complexity remains poorly understood. In this review, we explore the contributions of scRNA-seq studies to shed light on the tumor cells and cellular landscape of EC. We discuss the diverse tumoral and microenvironmental populations identified through scRNA-seq, highlighting the implications for understanding disease progression. Furthermore, we address potential limitations inherent in scRNA-seq studies, such as technical biases and sample size constraints, emphasizing the need for larger-scale research encompassing a broader spectrum of EC histological subtypes. Notably, a significant proportion of scRNA-seq analyses have focused on primary endometrioid carcinoma tumors, underscoring the need to incorporate additional histological and aggressive types to comprehensively capture the heterogeneity of EC. By critically evaluating the current state of scRNA-seq research in EC, this review underscores the importance of advancing towards more comprehensive studies to accelerate our understanding of this complex disease.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12080/54908
url https://hdl.handle.net/20.500.12080/54908
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad Alfonso X el Sabio
instname:Universidad Alfonso X el Sabio
instname_str Universidad Alfonso X el Sabio
reponame_str Repositorio Institucional de la Universidad Alfonso X el Sabio
collection Repositorio Institucional de la Universidad Alfonso X el Sabio
repository.name.fl_str_mv
repository.mail.fl_str_mv
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