Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study

Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions...

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Authors: Ferrer Fábrega, Joana, Folch i Puy, Emma, Lozano Salvatella, Juan José, Ventura Aguiar, Pedro, Cárdenas, Gabriel, Paredes, David, García Criado, Ángeles, Bombí, Josep Antoni, García Pérez, Rocío, López Boado, Miguel Ángel, Rull, Ramón, Esmatjes Mompó, Enric, Ricart Brulles, Ma. José, Diekmann, Fritz, Fondevila Campo, Constantino, Fernández Cruz, Laureano, Fuster Obregón, Josep, García-Valdecasas Salgado, Juan Carlos
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/185546
Online Access:https://hdl.handle.net/2445/185546
Access Level:Open access
Keyword:Trasplantament d'òrgans
Conservació d'òrgans
Pàncrees
Transplantation of organs
Preservation of organs
Pancreas
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spelling Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective studyFerrer Fábrega, JoanaFolch i Puy, EmmaLozano Salvatella, Juan JoséVentura Aguiar, PedroCárdenas, GabrielParedes, DavidGarcía Criado, ÁngelesBombí, Josep AntoniGarcía Pérez, RocíoLópez Boado, Miguel ÁngelRull, RamónEsmatjes Mompó, EnricRicart Brulles, Ma. JoséDiekmann, FritzFondevila Campo, ConstantinoFernández Cruz, LaureanoFuster Obregón, JosepGarcía-Valdecasas Salgado, Juan CarlosTrasplantament d'òrgansConservació d'òrgansPàncreesTransplantation of organsPreservation of organsPancreasDue to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis,Frontiers Media2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/185546Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/ti.2022.10419Transplant International, 2022, vol. 35, num. 10419https://doi.org/10.3389/ti.2022.10419cc-by (c) Ferrer Fábrega, Joana et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1855462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
title Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
spellingShingle Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
Ferrer Fábrega, Joana
Trasplantament d'òrgans
Conservació d'òrgans
Pàncrees
Transplantation of organs
Preservation of organs
Pancreas
title_short Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
title_full Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
title_fullStr Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
title_full_unstemmed Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
title_sort Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
dc.creator.none.fl_str_mv Ferrer Fábrega, Joana
Folch i Puy, Emma
Lozano Salvatella, Juan José
Ventura Aguiar, Pedro
Cárdenas, Gabriel
Paredes, David
García Criado, Ángeles
Bombí, Josep Antoni
García Pérez, Rocío
López Boado, Miguel Ángel
Rull, Ramón
Esmatjes Mompó, Enric
Ricart Brulles, Ma. José
Diekmann, Fritz
Fondevila Campo, Constantino
Fernández Cruz, Laureano
Fuster Obregón, Josep
García-Valdecasas Salgado, Juan Carlos
author Ferrer Fábrega, Joana
author_facet Ferrer Fábrega, Joana
Folch i Puy, Emma
Lozano Salvatella, Juan José
Ventura Aguiar, Pedro
Cárdenas, Gabriel
Paredes, David
García Criado, Ángeles
Bombí, Josep Antoni
García Pérez, Rocío
López Boado, Miguel Ángel
Rull, Ramón
Esmatjes Mompó, Enric
Ricart Brulles, Ma. José
Diekmann, Fritz
Fondevila Campo, Constantino
Fernández Cruz, Laureano
Fuster Obregón, Josep
García-Valdecasas Salgado, Juan Carlos
author_role author
author2 Folch i Puy, Emma
Lozano Salvatella, Juan José
Ventura Aguiar, Pedro
Cárdenas, Gabriel
Paredes, David
García Criado, Ángeles
Bombí, Josep Antoni
García Pérez, Rocío
López Boado, Miguel Ángel
Rull, Ramón
Esmatjes Mompó, Enric
Ricart Brulles, Ma. José
Diekmann, Fritz
Fondevila Campo, Constantino
Fernández Cruz, Laureano
Fuster Obregón, Josep
García-Valdecasas Salgado, Juan Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantament d'òrgans
Conservació d'òrgans
Pàncrees
Transplantation of organs
Preservation of organs
Pancreas
topic Trasplantament d'òrgans
Conservació d'òrgans
Pàncrees
Transplantation of organs
Preservation of organs
Pancreas
description Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis,
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185546
url https://hdl.handle.net/2445/185546
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/ti.2022.10419
Transplant International, 2022, vol. 35, num. 10419
https://doi.org/10.3389/ti.2022.10419
dc.rights.none.fl_str_mv cc-by (c) Ferrer Fábrega, Joana et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ferrer Fábrega, Joana et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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