Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to impro...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/46774 |
| Acceso en línea: | https://hdl.handle.net/2454/46774 |
| Access Level: | acceso abierto |
| Palabra clave: | Cytokines Hip fractures Biomarkers Prognosis FRAX |
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Effect of immunology biomarkers associated with hip fracture and fracture risk in older adultsCedeño Veloz, Bernardo AbelLozano Vicario, LucíaZambom Ferraresi, FabrícioFernández Irigoyen, JoaquínSantamaría Martínez, EnriqueRodríguez-García, AlbaRomero Ortuno, RománMondragón Rubio, JaimeRuiz-Ruiz, JavierRamírez Vélez, RobinsonIzquierdo Redín, MikelMartínez Velilla, NicolásCytokinesHip fracturesBiomarkersPrognosisFRAXOsteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In this observational study, we aimed to explore the association between serum cytokines and hip fracture status in older adults, and their associations with fracture risk using the FRAX reference tool. We investigated the use of a proximity extension assay (PEA) with Olink. We compared the characteristics of the population, functional status and detailed body composition (determined using densitometry) between groups. We enrolled 40 participants, including 20 with hip fracture and 20 without fracture, and studied 46 cytokines in their serum. After conducting a score plot and two unpaired t-tests using the Benjamini-Hochberg method, we found that Interleukin 6 (IL-6), Lymphotoxin-alpha (LT-α), Fms-related tyrosine kinase 3 ligand (FLT3LG), Colony stimulating factor 1 (CSF1), and Chemokine (C-C motif) ligand 7 (CCL7) were significantly different between fracture and non-fracture patients (p < 0.05). IL-6 had a moderate correlation with FRAX (R2 = 0.409, p < 0.001), while CSF1 and CCL7 had weak correlations with FRAX. LT-α and FLT3LG exhibited a negative correlation with the risk of fracture. Our results suggest that targeted proteomic tools have the capability to identify differentially regulated proteins and may serve as potential markers for estimating fracture risk. However, longitudinal studies will be necessary to validate these results and determine the temporal patterns of changes in cytokine profiles.Open Access funding provided by Universidad Pública de Navarra. Funding for this project came from NM-V received funding from the “La Caixa” Foundation (ID 100010434), under agreement LCF/PR/PR15/51100006. ES also received funding from the grant from Department of Economic and Business Development from Government of Navarra (Ref. 0011-1411-2023-000028).BMCCiencias de la SaludOsasun ZientziakUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/ziphttps://hdl.handle.net/2454/46774reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1411-2023-000028© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/467742026-06-17T12:41:47Z |
| dc.title.none.fl_str_mv |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| title |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| spellingShingle |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults Cedeño Veloz, Bernardo Abel Cytokines Hip fractures Biomarkers Prognosis FRAX |
| title_short |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| title_full |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| title_fullStr |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| title_full_unstemmed |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| title_sort |
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults |
| dc.creator.none.fl_str_mv |
Cedeño Veloz, Bernardo Abel Lozano Vicario, Lucía Zambom Ferraresi, Fabrício Fernández Irigoyen, Joaquín Santamaría Martínez, Enrique Rodríguez-García, Alba Romero Ortuno, Román Mondragón Rubio, Jaime Ruiz-Ruiz, Javier Ramírez Vélez, Robinson Izquierdo Redín, Mikel Martínez Velilla, Nicolás |
| author |
Cedeño Veloz, Bernardo Abel |
| author_facet |
Cedeño Veloz, Bernardo Abel Lozano Vicario, Lucía Zambom Ferraresi, Fabrício Fernández Irigoyen, Joaquín Santamaría Martínez, Enrique Rodríguez-García, Alba Romero Ortuno, Román Mondragón Rubio, Jaime Ruiz-Ruiz, Javier Ramírez Vélez, Robinson Izquierdo Redín, Mikel Martínez Velilla, Nicolás |
| author_role |
author |
| author2 |
Lozano Vicario, Lucía Zambom Ferraresi, Fabrício Fernández Irigoyen, Joaquín Santamaría Martínez, Enrique Rodríguez-García, Alba Romero Ortuno, Román Mondragón Rubio, Jaime Ruiz-Ruiz, Javier Ramírez Vélez, Robinson Izquierdo Redín, Mikel Martínez Velilla, Nicolás |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ciencias de la Salud Osasun Zientziak Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa |
| dc.subject.none.fl_str_mv |
Cytokines Hip fractures Biomarkers Prognosis FRAX |
| topic |
Cytokines Hip fractures Biomarkers Prognosis FRAX |
| description |
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In this observational study, we aimed to explore the association between serum cytokines and hip fracture status in older adults, and their associations with fracture risk using the FRAX reference tool. We investigated the use of a proximity extension assay (PEA) with Olink. We compared the characteristics of the population, functional status and detailed body composition (determined using densitometry) between groups. We enrolled 40 participants, including 20 with hip fracture and 20 without fracture, and studied 46 cytokines in their serum. After conducting a score plot and two unpaired t-tests using the Benjamini-Hochberg method, we found that Interleukin 6 (IL-6), Lymphotoxin-alpha (LT-α), Fms-related tyrosine kinase 3 ligand (FLT3LG), Colony stimulating factor 1 (CSF1), and Chemokine (C-C motif) ligand 7 (CCL7) were significantly different between fracture and non-fracture patients (p < 0.05). IL-6 had a moderate correlation with FRAX (R2 = 0.409, p < 0.001), while CSF1 and CCL7 had weak correlations with FRAX. LT-α and FLT3LG exhibited a negative correlation with the risk of fracture. Our results suggest that targeted proteomic tools have the capability to identify differentially regulated proteins and may serve as potential markers for estimating fracture risk. However, longitudinal studies will be necessary to validate these results and determine the temporal patterns of changes in cytokine profiles. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2454/46774 |
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https://hdl.handle.net/2454/46774 |
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Inglés |
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Inglés |
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info:eu-repo/grantAgreement/Gobierno de Navarra//0011-1411-2023-000028 |
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https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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