Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments

This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimerc...

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Detalhes bibliográficos
Autores: Fernández-Afonso, Yilian, Asín, Laura, Beola, Lilianne, Fratila, Raluca M., Gutiérrez, Lucía
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:120165
Acesso em linha:http://zaguan.unizar.es/record/120165
Access Level:acceso abierto
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spelling Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatmentsFernández-Afonso, YilianAsín, LauraBeola, LilianneFratila, Raluca M.Gutiérrez, LucíaThis work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimercaptosuccinic acid)] have been subjected to an accelerated degradation in a medium simulating lysosome conditions. The particles physicochemical properties (size, size distribution, and magnetic properties) have been followed over the degradation process along 24 days. It was found that DMSA-coated particles degraded much faster than PMAO-coated ones. In addition, their heating properties under both the exposure to an alternating magnetic field or a near infrared light have been tracked along this degradation processes, assessing how the changes in their physicochemical properties affect their heating capacity. Along the degradation procedure, a stronger decrease of the particles heating properties has been observed in the frame of magnetic hyperthermia measurements, in comparison with the photothermal ones. Finally, the PMAO-coated particles have been selected for a degradation study in vivo after intratumoral administration. Interestingly, although the number of particles decreases with time in the tissue, the size and size distribution of the particles do not change significantly over time. This work is especially relevant in the frame of the design of in vivo hyperthermia treatments using magnetic nanoparticles as it would provide fundamental clues regarding the need of repeated doses or the possible use of a single administration depending on the treatment duration.2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/120165reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/DGA-FEDER/E15-17Rinfo:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1201652026-05-29T13:59:51Z
dc.title.none.fl_str_mv Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
spellingShingle Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
Fernández-Afonso, Yilian
title_short Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_full Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_fullStr Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_full_unstemmed Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_sort Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
dc.creator.none.fl_str_mv Fernández-Afonso, Yilian
Asín, Laura
Beola, Lilianne
Fratila, Raluca M.
Gutiérrez, Lucía
author Fernández-Afonso, Yilian
author_facet Fernández-Afonso, Yilian
Asín, Laura
Beola, Lilianne
Fratila, Raluca M.
Gutiérrez, Lucía
author_role author
author2 Asín, Laura
Beola, Lilianne
Fratila, Raluca M.
Gutiérrez, Lucía
author2_role author
author
author
author
description This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimercaptosuccinic acid)] have been subjected to an accelerated degradation in a medium simulating lysosome conditions. The particles physicochemical properties (size, size distribution, and magnetic properties) have been followed over the degradation process along 24 days. It was found that DMSA-coated particles degraded much faster than PMAO-coated ones. In addition, their heating properties under both the exposure to an alternating magnetic field or a near infrared light have been tracked along this degradation processes, assessing how the changes in their physicochemical properties affect their heating capacity. Along the degradation procedure, a stronger decrease of the particles heating properties has been observed in the frame of magnetic hyperthermia measurements, in comparison with the photothermal ones. Finally, the PMAO-coated particles have been selected for a degradation study in vivo after intratumoral administration. Interestingly, although the number of particles decreases with time in the tissue, the size and size distribution of the particles do not change significantly over time. This work is especially relevant in the frame of the design of in vivo hyperthermia treatments using magnetic nanoparticles as it would provide fundamental clues regarding the need of repeated doses or the possible use of a single administration depending on the treatment duration.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/120165
url http://zaguan.unizar.es/record/120165
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/DGA-FEDER/E15-17R
info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00
info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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