RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation

[Background]: IRE1 is an unfolded protein response (UPR) sensor with kinase and endonuclease activity. It plays a central role in the endoplasmic reticulum (ER) stress response through unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay (RIDD). Multiple myeloma (MM) cells are kno...

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Detalles Bibliográficos
Autores: Quwaider, Dalia, Corchete, Luis A., Martín-Izquierdo, Marta, Hernandez-Sánchez, Jesus M., Rojas Mendoza, Ana M., Cardona-Benavides, Ignacio J., García-Sanz, Ramón, Herrero, Ana B., Gutiérrez, Norma Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/283145
Acceso en línea:http://hdl.handle.net/10261/283145
Access Level:acceso abierto
Palabra clave:ER stres
UPR
IRE1
RIDD
Multiple myeloma
Descripción
Sumario:[Background]: IRE1 is an unfolded protein response (UPR) sensor with kinase and endonuclease activity. It plays a central role in the endoplasmic reticulum (ER) stress response through unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay (RIDD). Multiple myeloma (MM) cells are known to exhibit an elevated level of baseline ER stress due to immunoglobulin production, however RIDD activity has not been well studied in this disease. In this study, we aimed to investigate the potential of RNA-sequencing in the identification of novel RIDD targets in MM cells and to analyze the role of these targets in MM cells.

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