Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models

Alpha-synuclein aggregation is the pathological feature of several neurodegenerative disorders, including Parkinson's disease. The aggregates can diffuse within brain areas, and their toxicity has been proven in both cellular and animal models. Given that, recent therapeutic strategies have bee...

Descripción completa

Detalles Bibliográficos
Autores: Basellini MJ, Granadino-Roldán JM, Torres-Ortega PV, Simmini G, Rubio-Martinez J, Marin S, Cappelletti G, Cascante M, Cañuelo A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p29375
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29375
Access Level:acceso abierto
Palabra clave:alpha-synuclein aggregation
Parkinson's disease
Synucleinopathy
Oleuropein aglycone
id ES_c146479dfcb5d80cce2a40cf2775bc0c
oai_identifier_str oai:fsjd.fundanetsuite.com:p29375
network_acronym_str ES
network_name_str España
repository_id_str
spelling Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease ModelsBasellini MJGranadino-Roldán JMTorres-Ortega PVSimmini GRubio-Martinez JMarin SCappelletti GCascante MCañuelo Aalpha-synuclein aggregationParkinson's diseaseSynucleinopathyOleuropein aglyconeAlpha-synuclein aggregation is the pathological feature of several neurodegenerative disorders, including Parkinson's disease. The aggregates can diffuse within brain areas, and their toxicity has been proven in both cellular and animal models. Given that, recent therapeutic strategies have been focusing on the identification of compounds able to promote the degradation of aggregates or, at least, to prevent the aggregation process. In this field, the use of natural-derived polyphenols has been proposed as a potential tool against alpha-synuclein pathology. On these bases, we tested the neuroprotective potential of oleuropein aglycone, an olive polyphenol, in two cellular and C. elegans-based models of Parkinson's disease. The compound was effective in reducing the burden of early-aggregates pathology upon alpha-synuclein overexpression in neuroblastoma cells, as well as neutralizing both the extent and the toxicity of administered preformed fibrils. In addition, oleuropein aglycone administration was beneficial for healthspan and lifespan in animals overexpressing alpha-synuclein, improved motor defects, recovered dopaminergic neuronal loss, and reduced the extent of alpha-synuclein pathology. Finally, through molecular modelling simulations, we propose a model for the alpha-synuclein and oleuropein aglycone interaction, predicting a dynamic that involves early alpha-synuclein oligomers. Overall, our results support the neuroprotective potential of oleuropein aglycone against alpha-synuclein aggregation and toxicity and shed light into the molecular features of these mechanisms, suggesting that further studies should be performed to gain insight about the neuroprotective actions of this polyphenol in humans.SPRINGER2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29375MOLECULAR NEUROBIOLOGYISSN: 08937648ISSNe: 15591182reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p293752026-05-27T12:37:41Z
dc.title.none.fl_str_mv Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
title Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
spellingShingle Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
Basellini MJ
alpha-synuclein aggregation
Parkinson's disease
Synucleinopathy
Oleuropein aglycone
title_short Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
title_full Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
title_fullStr Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
title_full_unstemmed Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
title_sort Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models
dc.creator.none.fl_str_mv Basellini MJ
Granadino-Roldán JM
Torres-Ortega PV
Simmini G
Rubio-Martinez J
Marin S
Cappelletti G
Cascante M
Cañuelo A
author Basellini MJ
author_facet Basellini MJ
Granadino-Roldán JM
Torres-Ortega PV
Simmini G
Rubio-Martinez J
Marin S
Cappelletti G
Cascante M
Cañuelo A
author_role author
author2 Granadino-Roldán JM
Torres-Ortega PV
Simmini G
Rubio-Martinez J
Marin S
Cappelletti G
Cascante M
Cañuelo A
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv alpha-synuclein aggregation
Parkinson's disease
Synucleinopathy
Oleuropein aglycone
topic alpha-synuclein aggregation
Parkinson's disease
Synucleinopathy
Oleuropein aglycone
description Alpha-synuclein aggregation is the pathological feature of several neurodegenerative disorders, including Parkinson's disease. The aggregates can diffuse within brain areas, and their toxicity has been proven in both cellular and animal models. Given that, recent therapeutic strategies have been focusing on the identification of compounds able to promote the degradation of aggregates or, at least, to prevent the aggregation process. In this field, the use of natural-derived polyphenols has been proposed as a potential tool against alpha-synuclein pathology. On these bases, we tested the neuroprotective potential of oleuropein aglycone, an olive polyphenol, in two cellular and C. elegans-based models of Parkinson's disease. The compound was effective in reducing the burden of early-aggregates pathology upon alpha-synuclein overexpression in neuroblastoma cells, as well as neutralizing both the extent and the toxicity of administered preformed fibrils. In addition, oleuropein aglycone administration was beneficial for healthspan and lifespan in animals overexpressing alpha-synuclein, improved motor defects, recovered dopaminergic neuronal loss, and reduced the extent of alpha-synuclein pathology. Finally, through molecular modelling simulations, we propose a model for the alpha-synuclein and oleuropein aglycone interaction, predicting a dynamic that involves early alpha-synuclein oligomers. Overall, our results support the neuroprotective potential of oleuropein aglycone against alpha-synuclein aggregation and toxicity and shed light into the molecular features of these mechanisms, suggesting that further studies should be performed to gain insight about the neuroprotective actions of this polyphenol in humans.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29375
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29375
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv MOLECULAR NEUROBIOLOGY
ISSN: 08937648
ISSNe: 15591182
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418546748981248
score 15.811543

Similares en LA Referencia