Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor

Traumatic events have been proposed to be associated with hypo-activity of the hypothalamic-pituitary-adrenal (HPA) axis, but data in animal models exposed to severe stressors are controversial and have important methodological concerns. Individual differences in resting or stress levels of corticos...

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Autores: Belda, Xavier|||0000-0003-0374-9546, Fuentes, Silvia|||0000-0002-8352-1068, Labad, Javier|||0000-0003-2214-1886, Nadal i Alemany, Roser|||0000-0001-8972-2525, Armario Garcia, Antonio|||0000-0001-9524-3635
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:288807
Acceso en línea:https://ddd.uab.cat/record/288807
https://dx.doi.org/urn:doi:10.1016/j.yhbeh.2020.104865
Access Level:acceso abierto
Palabra clave:Hypothalamic-pituitary-adrenal axis
PTSD
Immobilization stress
Individual differences
Aggregated data
Circadian rhythm
Hypercorticosteronemia
Hypocorticosteronemia
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spelling Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressorRelationship to pre-stress individual differences in resting corticosterone levelsBelda, Xavier|||0000-0003-0374-9546Fuentes, Silvia|||0000-0002-8352-1068Labad, Javier|||0000-0003-2214-1886Nadal i Alemany, Roser|||0000-0001-8972-2525Armario Garcia, Antonio|||0000-0001-9524-3635Hypothalamic-pituitary-adrenal axisPTSDImmobilization stressIndividual differencesAggregated dataCircadian rhythmHypercorticosteronemiaHypocorticosteronemiaTraumatic events have been proposed to be associated with hypo-activity of the hypothalamic-pituitary-adrenal (HPA) axis, but data in animal models exposed to severe stressors are controversial and have important methodological concerns. Individual differences in resting or stress levels of corticosterone might explain some of the inconsistencies. We then studied this issue in male rats exposed to 2 h immobilization on boards (IMO), a severe stressor. Thirty-six rats were blood sampled under resting conditions four times a day on three non-consecutive days. Then, they were assigned to control (n = 14) or IMO (n = 22) to study the HPA response to IMO, the stressor-induced alterations in the circadian pattern of corticosterone (CPCORT), and the behavioral and HPA responsiveness to an open-field. Individual differences in pre-IMO resting corticosterone were inconsistent, but averaging data markedly improved consistency. The CPCORT was markedly altered on day 1 post-IMO (higher trough and lower peak levels), less altered on day 3 and apparently normal on day 7. Importantly, when rats were classified in low and high resting corticosterone groups (LCORT and HCORT, respectively), on the basis of the area under the curve (AUC) of the averaged pre-IMO data, AUC differences between LCORT and HCORT groups were maintained in controls but disappeared in IMO rats during the post-IMO week. Open-field hypo-activity and corticosterone sensitization were similar in LCORT and HCORT groups nine days after IMO. A single IMO exposure causes long-lasting HPA alterations, some of them dependent on pre-stress resting corticosterone levels, with no evidence for post-IMO resting corticosterone hypo-activity.Universitat Autònoma de Barcelona. Institut de Neurociències 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/288807https://dx.doi.org/urn:doi:10.1016/j.yhbeh.2020.104865reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-457Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-83430-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2888072026-06-06T12:50:31Z
dc.title.none.fl_str_mv Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
Relationship to pre-stress individual differences in resting corticosterone levels
title Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
spellingShingle Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
Belda, Xavier|||0000-0003-0374-9546
Hypothalamic-pituitary-adrenal axis
PTSD
Immobilization stress
Individual differences
Aggregated data
Circadian rhythm
Hypercorticosteronemia
Hypocorticosteronemia
title_short Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
title_full Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
title_fullStr Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
title_full_unstemmed Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
title_sort Acute exposure of rats to a severe stressor alters the circadian pattern of corticosterone and sensitizes to a novel stressor
dc.creator.none.fl_str_mv Belda, Xavier|||0000-0003-0374-9546
Fuentes, Silvia|||0000-0002-8352-1068
Labad, Javier|||0000-0003-2214-1886
Nadal i Alemany, Roser|||0000-0001-8972-2525
Armario Garcia, Antonio|||0000-0001-9524-3635
author Belda, Xavier|||0000-0003-0374-9546
author_facet Belda, Xavier|||0000-0003-0374-9546
Fuentes, Silvia|||0000-0002-8352-1068
Labad, Javier|||0000-0003-2214-1886
Nadal i Alemany, Roser|||0000-0001-8972-2525
Armario Garcia, Antonio|||0000-0001-9524-3635
author_role author
author2 Fuentes, Silvia|||0000-0002-8352-1068
Labad, Javier|||0000-0003-2214-1886
Nadal i Alemany, Roser|||0000-0001-8972-2525
Armario Garcia, Antonio|||0000-0001-9524-3635
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Institut de Neurociències
dc.subject.none.fl_str_mv Hypothalamic-pituitary-adrenal axis
PTSD
Immobilization stress
Individual differences
Aggregated data
Circadian rhythm
Hypercorticosteronemia
Hypocorticosteronemia
topic Hypothalamic-pituitary-adrenal axis
PTSD
Immobilization stress
Individual differences
Aggregated data
Circadian rhythm
Hypercorticosteronemia
Hypocorticosteronemia
description Traumatic events have been proposed to be associated with hypo-activity of the hypothalamic-pituitary-adrenal (HPA) axis, but data in animal models exposed to severe stressors are controversial and have important methodological concerns. Individual differences in resting or stress levels of corticosterone might explain some of the inconsistencies. We then studied this issue in male rats exposed to 2 h immobilization on boards (IMO), a severe stressor. Thirty-six rats were blood sampled under resting conditions four times a day on three non-consecutive days. Then, they were assigned to control (n = 14) or IMO (n = 22) to study the HPA response to IMO, the stressor-induced alterations in the circadian pattern of corticosterone (CPCORT), and the behavioral and HPA responsiveness to an open-field. Individual differences in pre-IMO resting corticosterone were inconsistent, but averaging data markedly improved consistency. The CPCORT was markedly altered on day 1 post-IMO (higher trough and lower peak levels), less altered on day 3 and apparently normal on day 7. Importantly, when rats were classified in low and high resting corticosterone groups (LCORT and HCORT, respectively), on the basis of the area under the curve (AUC) of the averaged pre-IMO data, AUC differences between LCORT and HCORT groups were maintained in controls but disappeared in IMO rats during the post-IMO week. Open-field hypo-activity and corticosterone sensitization were similar in LCORT and HCORT groups nine days after IMO. A single IMO exposure causes long-lasting HPA alterations, some of them dependent on pre-stress resting corticosterone levels, with no evidence for post-IMO resting corticosterone hypo-activity.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/288807
https://dx.doi.org/urn:doi:10.1016/j.yhbeh.2020.104865
url https://ddd.uab.cat/record/288807
https://dx.doi.org/urn:doi:10.1016/j.yhbeh.2020.104865
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-457
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-83430-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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