Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot

[Aims] Slow conduction (SC) anatomical isthmuses (AIs) are the dominant substrate for monomorphic ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTF). This study aimed to evaluate the utility of automated propagational analysis for the identification of SC-AI in patients...

ver descrição completa

Detalhes bibliográficos
Autores: Arana-Rueda, Eduardo, Acosta, Juan, Frutos‐López, Manuel, Sánchez-Brotons, Juan Antonio, González de la Portilla-Concha, Carmen, Gallego, Pastora, Pedrote, Alonso
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/368215
Acesso em linha:http://hdl.handle.net/10261/368215
https://api.elsevier.com/content/abstract/scopus_id/85189375449
Access Level:acceso abierto
Palavra-chave:Tetralogy of Fallot
Catheter ablation
Congenital heart disease
Electroanatomical mapping
id ES_c138ae97e5b2ce95ed37ad1eb4da962e
oai_identifier_str oai:digital.csic.es:10261/368215
network_acronym_str ES
network_name_str España
repository_id_str
spelling Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of FallotArana-Rueda, EduardoAcosta, JuanFrutos‐López, ManuelSánchez-Brotons, Juan AntonioGonzález de la Portilla-Concha, CarmenGallego, PastoraPedrote, AlonsoTetralogy of FallotCatheter ablationCongenital heart diseaseElectroanatomical mapping[Aims] Slow conduction (SC) anatomical isthmuses (AIs) are the dominant substrate for monomorphic ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTF). This study aimed to evaluate the utility of automated propagational analysis for the identification of SC-AI in patients with rTF.[Methods and results] Consecutive rTF patients undergoing VT substrate characterization were included. Automated isochronal late activation maps (ILAM) were obtained with multielectrode HD Grid Catheter. Identified deceleration zones (DZs) were compared with both SC-AI defined by conduction velocity (CV) (<0.5 m/s) and isthmuses of induced VT for mechanistic correlation. Fourteen patients were included (age 48; p25–75 35–52 years; 57% male), 2 with spontaneous VT and 12 for risk stratification. Nine VTs were inducible in seven patients. Procedure time was 140 (p25–75 133–180) min and mapping time 29.5 (p25–75 20–37.7) min, using a median of 2167 points. All the patients had at least one AI by substrate mapping, identifying a total of 27 (11 SC-AIs). Isochronal late activation maps detected 10 DZs mostly in the AI between ventricular septal defect and pulmonary valve (80%). Five patients had no DZs. A significant negative correlation between number of isochrones/cm and CV was observed (rho −0.87; P < 0.001). Deceleration zones correctly identified SC-AI (90% sensitivity; 100% specificity; 0.94 accuracy) and was related to VT inducibility (P = 0.006). Deceleration zones co-localized to the critical isthmus of induced VTs in 88% of cases. No complications were observed.[Conclusion] Deceleration zones displayed by ILAM during sinus rhythm accurately identify SC-AIs in rTF patients allowing a safe and short-time VT substrate characterization procedure.This work was supported by grants from the Consejería de Salud of the Junta de Andalucía (PI-0500-2019).Peer reviewedOxford University PressJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/368215https://api.elsevier.com/content/abstract/scopus_id/85189375449reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1093/europace/euae062https://doi.org/10.1093/europace/euae062Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3682152026-05-22T06:33:51Z
dc.title.none.fl_str_mv Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
title Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
spellingShingle Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
Arana-Rueda, Eduardo
Tetralogy of Fallot
Catheter ablation
Congenital heart disease
Electroanatomical mapping
title_short Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
title_full Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
title_fullStr Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
title_full_unstemmed Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
title_sort Automated isochronal late activation mapping for substrate characterization in patients with repaired tetralogy of Fallot
dc.creator.none.fl_str_mv Arana-Rueda, Eduardo
Acosta, Juan
Frutos‐López, Manuel
Sánchez-Brotons, Juan Antonio
González de la Portilla-Concha, Carmen
Gallego, Pastora
Pedrote, Alonso
author Arana-Rueda, Eduardo
author_facet Arana-Rueda, Eduardo
Acosta, Juan
Frutos‐López, Manuel
Sánchez-Brotons, Juan Antonio
González de la Portilla-Concha, Carmen
Gallego, Pastora
Pedrote, Alonso
author_role author
author2 Acosta, Juan
Frutos‐López, Manuel
Sánchez-Brotons, Juan Antonio
González de la Portilla-Concha, Carmen
Gallego, Pastora
Pedrote, Alonso
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tetralogy of Fallot
Catheter ablation
Congenital heart disease
Electroanatomical mapping
topic Tetralogy of Fallot
Catheter ablation
Congenital heart disease
Electroanatomical mapping
description [Aims] Slow conduction (SC) anatomical isthmuses (AIs) are the dominant substrate for monomorphic ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTF). This study aimed to evaluate the utility of automated propagational analysis for the identification of SC-AI in patients with rTF.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/368215
https://api.elsevier.com/content/abstract/scopus_id/85189375449
url http://hdl.handle.net/10261/368215
https://api.elsevier.com/content/abstract/scopus_id/85189375449
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1093/europace/euae062
https://doi.org/10.1093/europace/euae062
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418542227521536
score 15,811543

Registos relacionados