Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function

Objectives: Neuroimaging studies of dyskinetic cerebral palsy (CP) are scarce and the neuropathological underpinnings are not fully understood. We delineated the corticospinal tract (CST) and cortico-striatal-thalamocortical (CSTC) pathways with probabilistic tractography to assess their (1) integri...

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Autores: Laporta-Hoyos, Olga, Caldú i Ferrús, Xavier, Reid, Lee B., Pannek, Kerstin, Fripp, Jurgen, Ballester Plané, Júlia, Leiva Ureña, David, Boyd, Roslyn N., Pueyo Benito, Roser
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/226271
Acceso en línea:https://hdl.handle.net/2445/226271
http://hdl.handle.net/2445/226271
Access Level:acceso abierto
Palabra clave:Paràlisi cerebral
Estudi de casos
Motricitat
Cerebral palsy
Case studies
Motor ability
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spelling  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor functionLaporta-Hoyos, OlgaCaldú i Ferrús, XavierReid, Lee B.Pannek, KerstinFripp, JurgenBallester Plané, JúliaLeiva Ureña, DavidBoyd, Roslyn N.Pueyo Benito, RoserParàlisi cerebralEstudi de casosMotricitatCerebral palsyCase studiesMotor abilityObjectives: Neuroimaging studies of dyskinetic cerebral palsy (CP) are scarce and the neuropathological underpinnings are not fully understood. We delineated the corticospinal tract (CST) and cortico-striatal-thalamocortical (CSTC) pathways with probabilistic tractography to assess their (1) integrity and (2) association with motor functioning in people with dyskinetic CP. Methods: Diffusion weighted magnetic resonance images were obtained for 33 individuals with dyskinetic CP and 33 controls. Fractional anisotropy (FA) and mean diffusivity (MD) for the CST and the CSTC pathways were compared between groups. Correlation analyses were performed between tensor metric values and motor function scores of participants with dyskinetic CP as assessed by the Gross Motor Function Classification System (GMFCS), the Bimanual Fine Motor Function (BFMF), and the Manual Ability Classification System (MACS). Results: White matter integrity in both the CST and the CSTC pathways was reduced in people with dyskinetic CP. The GMFCS, MACS and, less commonly, the BFMF were associated with FA and, particularly, MD in most portions of these pathways. Interpretation: The present study advances our understanding of the involvement of white matter microstructure in sensorimotor pathways and its relationship with motor impairment in people with dyskinetic CP. Our results are consistent with well-described relationships between upper limb function and white matter integrity in the CST and CSTC pathways in other forms of CP. This knowledge may ultimately help prognosis and therapeutic programmes.American Neurological Association2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/226271http://hdl.handle.net/2445/226271reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/acn3.52174Annals of Clinical and Translational Neurology, 2024, vol. 11, num.10, p. 2609-2622https://doi.org/10.1002/acn3.52174cc-by-nc-nd (c) Caldú, X. et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2262712026-05-29T05:05:01Z
dc.title.none.fl_str_mv  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
title  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
spellingShingle  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
Laporta-Hoyos, Olga
Paràlisi cerebral
Estudi de casos
Motricitat
Cerebral palsy
Case studies
Motor ability
title_short  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
title_full  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
title_fullStr  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
title_full_unstemmed  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
title_sort  Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
dc.creator.none.fl_str_mv Laporta-Hoyos, Olga
Caldú i Ferrús, Xavier
Reid, Lee B.
Pannek, Kerstin
Fripp, Jurgen
Ballester Plané, Júlia
Leiva Ureña, David
Boyd, Roslyn N.
Pueyo Benito, Roser
author Laporta-Hoyos, Olga
author_facet Laporta-Hoyos, Olga
Caldú i Ferrús, Xavier
Reid, Lee B.
Pannek, Kerstin
Fripp, Jurgen
Ballester Plané, Júlia
Leiva Ureña, David
Boyd, Roslyn N.
Pueyo Benito, Roser
author_role author
author2 Caldú i Ferrús, Xavier
Reid, Lee B.
Pannek, Kerstin
Fripp, Jurgen
Ballester Plané, Júlia
Leiva Ureña, David
Boyd, Roslyn N.
Pueyo Benito, Roser
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Paràlisi cerebral
Estudi de casos
Motricitat
Cerebral palsy
Case studies
Motor ability
topic Paràlisi cerebral
Estudi de casos
Motricitat
Cerebral palsy
Case studies
Motor ability
description Objectives: Neuroimaging studies of dyskinetic cerebral palsy (CP) are scarce and the neuropathological underpinnings are not fully understood. We delineated the corticospinal tract (CST) and cortico-striatal-thalamocortical (CSTC) pathways with probabilistic tractography to assess their (1) integrity and (2) association with motor functioning in people with dyskinetic CP. Methods: Diffusion weighted magnetic resonance images were obtained for 33 individuals with dyskinetic CP and 33 controls. Fractional anisotropy (FA) and mean diffusivity (MD) for the CST and the CSTC pathways were compared between groups. Correlation analyses were performed between tensor metric values and motor function scores of participants with dyskinetic CP as assessed by the Gross Motor Function Classification System (GMFCS), the Bimanual Fine Motor Function (BFMF), and the Manual Ability Classification System (MACS). Results: White matter integrity in both the CST and the CSTC pathways was reduced in people with dyskinetic CP. The GMFCS, MACS and, less commonly, the BFMF were associated with FA and, particularly, MD in most portions of these pathways. Interpretation: The present study advances our understanding of the involvement of white matter microstructure in sensorimotor pathways and its relationship with motor impairment in people with dyskinetic CP. Our results are consistent with well-described relationships between upper limb function and white matter integrity in the CST and CSTC pathways in other forms of CP. This knowledge may ultimately help prognosis and therapeutic programmes.
publishDate 2024
dc.date.none.fl_str_mv 2024
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226271
http://hdl.handle.net/2445/226271
url https://hdl.handle.net/2445/226271
http://hdl.handle.net/2445/226271
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/acn3.52174
Annals of Clinical and Translational Neurology, 2024, vol. 11, num.10, p. 2609-2622
https://doi.org/10.1002/acn3.52174
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Caldú, X. et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Caldú, X. et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv American Neurological Association
publisher.none.fl_str_mv American Neurological Association
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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