Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion

Cruciferous vegetables are gaining importance as nutritious and sustainable foods, rich in phytochemical compounds such as glucosinolates (GSLs). However, the breakdown products of these sulfur-based compounds, mainly represented by isothiocyanates (ITC) and indoles, can contribute to human health....

Descripción completa

Detalles Bibliográficos
Autores: Abellán, Ángel, Domínguez-Perles, Raúl, García-Viguera, Cristina, Moreno, Diego A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/415606
Acceso en línea:http://hdl.handle.net/10261/415606
https://api.elsevier.com/content/abstract/scopus_id/85116983122
Access Level:acceso abierto
Palabra clave:Bioaccessibility
Brassica
Indoles
Isothiocyanates
Sprouts
Sulfur-based compounds
id ES_c0dd2af2d9e93b33285aec7e84f929f3
oai_identifier_str oai:digital.csic.es:10261/415606
network_acronym_str ES
network_name_str España
repository_id_str
spelling Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal DigestionAbellán, ÁngelDomínguez-Perles, RaúlGarcía-Viguera, CristinaMoreno, Diego A.BioaccessibilityBrassicaIndolesIsothiocyanatesSproutsSulfur-based compoundsCruciferous vegetables are gaining importance as nutritious and sustainable foods, rich in phytochemical compounds such as glucosinolates (GSLs). However, the breakdown products of these sulfur-based compounds, mainly represented by isothiocyanates (ITC) and indoles, can contribute to human health. In the human digestive system, the formation of these compounds continues to varying extents in the different stages of digestion, due to the contact of GSLs with different gastric fluids and enzymes under the physicochemical conditions of the gastrointestinal tract. Therefore, the aim of the present work was to uncover the effect of gastrointestinal digestion on the release of glucosinolates and their transformation into their bioactive counterparts by applying a simulated in vitro static model on a range of brassica (red radish, red cabbage, broccoli, and mustard) sprouts. In this sense, significantly higher bioaccessibility of ITC and indoles from GSLs of red cabbage sprouts was observed in comparison with broccoli, red radish, and mustard sprouts, due to the aliphatic GSLs proportion present in the different sprouts. This indicates that the bioaccessibility of GSLs from Brasicaceae sprouts is not exclusively associated with the initial content of these compounds in the plant material (almost negligible), but also with the release of GSLs and the ongoing breakdown reactions during the gastric and intestinal phases of digestion, respectively. Additionally, aliphatic GSLs provided higher bioaccessibility of their corresponding ITC in comparison to indolic and aromatic GSLs.This research was supported by Fundación Seneca—Murcia Regional Agency for Science and Technology (CARM), Project Reference N# 20855/PI/18 and the Spanish project AGL2020-120660RA-I00 from the Spanish Ministry of Science and InnovationPeer reviewedMultidisciplinary Digital Publishing InstituteFundación SénecaMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Moreno, Diego A. [0000-0002-6547-8764]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/415606https://api.elsevier.com/content/abstract/scopus_id/85116983122reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational journal of molecular scienceshttps://doi.org/10.3390/ijms222011046Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4156062026-05-22T06:33:51Z
dc.title.none.fl_str_mv Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
title Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
spellingShingle Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
Abellán, Ángel
Bioaccessibility
Brassica
Indoles
Isothiocyanates
Sprouts
Sulfur-based compounds
title_short Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
title_full Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
title_fullStr Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
title_full_unstemmed Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
title_sort Evidence on the Bioaccessibility of Glucosinolates and Breakdown Products of Cruciferous Sprouts by Simulated In Vitro Gastrointestinal Digestion
dc.creator.none.fl_str_mv Abellán, Ángel
Domínguez-Perles, Raúl
García-Viguera, Cristina
Moreno, Diego A.
author Abellán, Ángel
author_facet Abellán, Ángel
Domínguez-Perles, Raúl
García-Viguera, Cristina
Moreno, Diego A.
author_role author
author2 Domínguez-Perles, Raúl
García-Viguera, Cristina
Moreno, Diego A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Fundación Séneca
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Moreno, Diego A. [0000-0002-6547-8764]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bioaccessibility
Brassica
Indoles
Isothiocyanates
Sprouts
Sulfur-based compounds
topic Bioaccessibility
Brassica
Indoles
Isothiocyanates
Sprouts
Sulfur-based compounds
description Cruciferous vegetables are gaining importance as nutritious and sustainable foods, rich in phytochemical compounds such as glucosinolates (GSLs). However, the breakdown products of these sulfur-based compounds, mainly represented by isothiocyanates (ITC) and indoles, can contribute to human health. In the human digestive system, the formation of these compounds continues to varying extents in the different stages of digestion, due to the contact of GSLs with different gastric fluids and enzymes under the physicochemical conditions of the gastrointestinal tract. Therefore, the aim of the present work was to uncover the effect of gastrointestinal digestion on the release of glucosinolates and their transformation into their bioactive counterparts by applying a simulated in vitro static model on a range of brassica (red radish, red cabbage, broccoli, and mustard) sprouts. In this sense, significantly higher bioaccessibility of ITC and indoles from GSLs of red cabbage sprouts was observed in comparison with broccoli, red radish, and mustard sprouts, due to the aliphatic GSLs proportion present in the different sprouts. This indicates that the bioaccessibility of GSLs from Brasicaceae sprouts is not exclusively associated with the initial content of these compounds in the plant material (almost negligible), but also with the release of GSLs and the ongoing breakdown reactions during the gastric and intestinal phases of digestion, respectively. Additionally, aliphatic GSLs provided higher bioaccessibility of their corresponding ITC in comparison to indolic and aromatic GSLs.
publishDate 2021
dc.date.none.fl_str_mv 2021
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/415606
https://api.elsevier.com/content/abstract/scopus_id/85116983122
url http://hdl.handle.net/10261/415606
https://api.elsevier.com/content/abstract/scopus_id/85116983122
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of molecular sciences
https://doi.org/10.3390/ijms222011046
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418513145266176
score 15,812429

Similares en LA Referencia