Electrical stimulation of the medial forebrain bundle as a potential therapy for Alzheimer's disease: effects on molecular markers in rodent model
Electrical stimulation of deep brain areas has been suggested as a novel approach to restore memory circuits in Alzheimer’s disease (AD). Previous studies from our group have demonstrated that rewarding stimulation of the medial forebrain bundle (MFB-ICSS) facilitates learning and memory in healthy...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/672300 |
| Acceso en línea: | http://hdl.handle.net/10803/672300 |
| Access Level: | acceso abierto |
| Palabra clave: | Malaltia d'Alzheimer Enfermedad de Alzheimer Alzheimer's disease AD Estimulació cerebral profunda Estimulación cerebral profunda Deep brain stimulation DBS Estimulació elèctrica Estimulación eléctrica Electrical stimulation Autoestimulació intracranial Autoestimulación intracraneal Intracranial self-stimulation ICSS Feix prosencefàlic medial Haz prosencefálico medial Medial forebrain bundle MFB Marcadors moleculars Marcadores moleculares Molecular markers 577 616.8 |
| Sumario: | Electrical stimulation of deep brain areas has been suggested as a novel approach to restore memory circuits in Alzheimer’s disease (AD). Previous studies from our group have demonstrated that rewarding stimulation of the medial forebrain bundle (MFB-ICSS) facilitates learning and memory in healthy and brain-lesioned rats. This thesis assesses for the first time the effect of MFB-ICSS on AD-associated molecules and its relation with cognitive outcome in rats, including amyloid-β and streptozotocin sporadic AD models. Results confirmed that MFB-ICSS modulates AD-related molecules and facilitates memory in this condition. Specifically, amyloid precursor protein (APP), phosphorylated tau and key gene expression regulators like SIRT1 and particular microRNAs are modulated by MFB-ICSS in the hippocampus of treated rats. Moreover, effects on miR-132 and SIRT1 were also observed in blood, suggesting a potential use of these molecules as non-invasive biomarkers. Altogether, these data sustain the MFB as a promising stimulation target for AD treatment. |
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