Light and Enzymatic Cooperative Response in Supramolecular Fibers: A Synergistic Strategy for Potential Drug Delivery Applications
Supramolecular Polymers (SPs) can undergo reversible self-assembly in response to internal or external stimuli. Design strategies based on the benzene-1,3,5-tricarboxamide (BTA) core are gaining increasing attention. In this study, we describe a BTA amphiphile that self-assembles into supramolecular...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2026 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:dnet:recercat____::2f1f0a2b7f90b84380d8cd3e2a262c43 |
| Acesso em linha: | https://hdl.handle.net/2072/489573 https://doi.org/10.1021/acs.biomac.6c00354 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Química 54 |
| Resumo: | Supramolecular Polymers (SPs) can undergo reversible self-assembly in response to internal or external stimuli. Design strategies based on the benzene-1,3,5-tricarboxamide (BTA) core are gaining increasing attention. In this study, we describe a BTA amphiphile that self-assembles into supramolecular fibers in water and is able to respond to both light and enzymatic activity. An azobenzene moiety (AZB) and Gly-Phe-Leu-Gly amino acid sequence (GFLG) were incorporated into the BTA monomer skeleton to build three identical wedges that respond to light and Cathepsin B activity. The synergistic application of two orthogonal stimuli enabled modulation of the assembly of BTA-AZB-GFLG fibers through the cooperative response to stimuli. These findings provide new insights into the use of SPs for future drug delivery applications. |
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