Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.

BACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. OBJECTIVE: To...

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Autores: Hildur, Kristin, Templado, Cristina, Zock, Jan-Paul, Giraldo, Jesús, Pozo Rodríguez, Francisco, Frances, Alexandra, Monyarch, Gemma, Rodríguez Trigo, Gema, Rodriguez-Rodriguez, Emma, Souto, Ana, Gómez, Federico P., Antó i Boqué, Josep Maria, Barberà, Joan Albert, Fuster, Carme
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/24813
Acceso en línea:http://hdl.handle.net/10230/24813
http://dx.doi.org/10.1371/journal.pone.0132413
Access Level:acceso abierto
Palabra clave:Prestige, Catàstrofe del, Espanya, 2002
Cromosomes humans -- Anomalies
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spelling Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.Hildur, KristinTemplado, CristinaZock, Jan-PaulGiraldo, JesúsPozo Rodríguez, FranciscoFrances, AlexandraMonyarch, GemmaRodríguez Trigo, GemaRodriguez-Rodriguez, EmmaSouto, AnaGómez, Federico P.Antó i Boqué, Josep MariaBarberà, Joan AlbertFuster, CarmePrestige, Catàstrofe del, Espanya, 2002Cromosomes humans -- AnomaliesBACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. OBJECTIVE: To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. DESIGN: Follow-up study. SETTING: Fishermen cooperatives in coastal villages. PARTICIPANTS: Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. MEASUREMENTS: Chromosome damage in circulating lymphocytes. RESULTS: Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. LIMITATIONS: The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. CONCLUSION: The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals.This study was provided by grants from the Health Institute Carlos III FEDER/ERDF (PI03/1685; PI07/0086), Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Comissionat per a Universitats i Recerca from Generalitat de Catalunya (SGR14-903; FI-00312), Centro de Investigación en Red de Enfermedades Respiratorias and Universidad Autónoma de Barcelona (PS-456-01/08).Public Library of Science201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/24813http://dx.doi.org/10.1371/journal.pone.0132413reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésPLoS One. 2015 Jul 29;10(7):e0132413© 2015 Hildur et al. This is an open access article distributed under the terms of thehttp://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/248132026-06-12T07:21:37Z
dc.title.none.fl_str_mv Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
title Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
spellingShingle Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
Hildur, Kristin
Prestige, Catàstrofe del, Espanya, 2002
Cromosomes humans -- Anomalies
title_short Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
title_full Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
title_fullStr Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
title_full_unstemmed Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
title_sort Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.
dc.creator.none.fl_str_mv Hildur, Kristin
Templado, Cristina
Zock, Jan-Paul
Giraldo, Jesús
Pozo Rodríguez, Francisco
Frances, Alexandra
Monyarch, Gemma
Rodríguez Trigo, Gema
Rodriguez-Rodriguez, Emma
Souto, Ana
Gómez, Federico P.
Antó i Boqué, Josep Maria
Barberà, Joan Albert
Fuster, Carme
author Hildur, Kristin
author_facet Hildur, Kristin
Templado, Cristina
Zock, Jan-Paul
Giraldo, Jesús
Pozo Rodríguez, Francisco
Frances, Alexandra
Monyarch, Gemma
Rodríguez Trigo, Gema
Rodriguez-Rodriguez, Emma
Souto, Ana
Gómez, Federico P.
Antó i Boqué, Josep Maria
Barberà, Joan Albert
Fuster, Carme
author_role author
author2 Templado, Cristina
Zock, Jan-Paul
Giraldo, Jesús
Pozo Rodríguez, Francisco
Frances, Alexandra
Monyarch, Gemma
Rodríguez Trigo, Gema
Rodriguez-Rodriguez, Emma
Souto, Ana
Gómez, Federico P.
Antó i Boqué, Josep Maria
Barberà, Joan Albert
Fuster, Carme
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prestige, Catàstrofe del, Espanya, 2002
Cromosomes humans -- Anomalies
topic Prestige, Catàstrofe del, Espanya, 2002
Cromosomes humans -- Anomalies
description BACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. OBJECTIVE: To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. DESIGN: Follow-up study. SETTING: Fishermen cooperatives in coastal villages. PARTICIPANTS: Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. MEASUREMENTS: Chromosome damage in circulating lymphocytes. RESULTS: Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. LIMITATIONS: The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. CONCLUSION: The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/24813
http://dx.doi.org/10.1371/journal.pone.0132413
url http://hdl.handle.net/10230/24813
http://dx.doi.org/10.1371/journal.pone.0132413
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS One. 2015 Jul 29;10(7):e0132413
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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