Increased let-7d-5p in non-alcoholic fatty liver promotes insulin resistance and is a potential blood biomarker for diagnosis

[Background and Aims]: The molecular mechanisms driving non-alcoholic fatty liver disease (NAFLD) are poorly understood; however, microRNAs might play a key role in these processes. We hypothesize that let-7d- 5p could contribute to the pathophysiol-ogy of NAFLD and serve as a potential diagnostic b...

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Detalles Bibliográficos
Autores: Infante-Menéndez, Jorge, López-Pastor, Andrea R., González-Illanes, Tamara, González-López, Paula, Huertas-Lárez, Raquel, Rey, Esther, González-Rodríguez, Águeda, García-Monzón, Carmelo, Patil, Nikita P., Vega de Céniga, Melina, Baker, Aaron B., Gómez-Hernández, Almudena, Escribano, Óscar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/353820
Acceso en línea:http://hdl.handle.net/10261/353820
Access Level:acceso abierto
Palabra clave:Steatosis
Insulin signalling
miRNAs
Diagnostic biomarker
Insulin resistance
Descripción
Sumario:[Background and Aims]: The molecular mechanisms driving non-alcoholic fatty liver disease (NAFLD) are poorly understood; however, microRNAs might play a key role in these processes. We hypothesize that let-7d- 5p could contribute to the pathophysiol-ogy of NAFLD and serve as a potential diagnostic biomarker.

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