Dietary and microbiome factors determine longevity in Caenorhabditis elegans

Diet composition affects organismal health. Nutrient uptake depends on the microbiome. Caenorhabditis elegans fed a Bacillus subtilis diet live longer than those fed the standard Escherichia coli diet. Here we report that this longevity difference is primarily caused by dietary coQ, an antioxidant s...

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Detalhes bibliográficos
Autores: Sánchez-Blanco, Adolfo, Rodríguez-Matellán, Alberto G., González-Paramas, Ana, González-Manzano, Susana, Kim, Stuart K., Mollinedo, Faustino
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/136894
Acesso em linha:http://hdl.handle.net/10261/136894
Access Level:acceso abierto
Palavra-chave:C. elegans
Longevity
Microbiome
Oxidants
Coenzyme Q
Redox homeostasis
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spelling Dietary and microbiome factors determine longevity in Caenorhabditis elegansSánchez-Blanco, AdolfoRodríguez-Matellán, Alberto G.González-Paramas, AnaGonzález-Manzano, SusanaKim, Stuart K.Mollinedo, FaustinoC. elegansLongevityMicrobiomeOxidantsCoenzyme QRedox homeostasisDiet composition affects organismal health. Nutrient uptake depends on the microbiome. Caenorhabditis elegans fed a Bacillus subtilis diet live longer than those fed the standard Escherichia coli diet. Here we report that this longevity difference is primarily caused by dietary coQ, an antioxidant synthesized by E. coli but not by B. subtilis. CoQ‐supplemented E. coli fed worms have a lower oxidation state yet live shorter than coQ‐less B. subtilis fed worms. We showed that mutations affecting longevity for E. coli fed worms do not always lead to similar effects when worms are fed B. subtilis. We propose that coQ supplementation by the E. coli diet alters the worm cellular REDOX homeostasis, thus decreasing longevity. Our results highlight the importance of microbiome factors in longevity, argue that antioxidant supplementation can be detrimental, and suggest that the C. elegans standard E. coli diet can alter the effect of signaling pathways on longevity.This work was supported by grants to FM from the Spanish Ministerio de Economía y Competitividad (SAF2011-30518, SAF2014-59716-R, and RD12/0036/0065 from Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III, cofunded by the Fondo Europeo de Desarrollo Regional of the European Union), and European Community’s 7th Framework Programme (HEALTH-F2-2011-256986, PANACREAS). AS-B was supported by the CSIC JAEDoc program and by the Stanford Center on Longevity. The Grupo de Investigación en Polifenoles was supported by the Spanish Ministerio de Economía y Competitividad (BFU2012-35228).Peer reviewedImpact JournalsMinisterio de Economía y Competitividad (España)Instituto de Salud Carlos IIIEuropean CommissionConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/136894reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/256986info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-59716-Rhttp://dx.doi.org/ 10.18632/aging.101008Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1368942026-05-22T06:33:51Z
dc.title.none.fl_str_mv Dietary and microbiome factors determine longevity in Caenorhabditis elegans
title Dietary and microbiome factors determine longevity in Caenorhabditis elegans
spellingShingle Dietary and microbiome factors determine longevity in Caenorhabditis elegans
Sánchez-Blanco, Adolfo
C. elegans
Longevity
Microbiome
Oxidants
Coenzyme Q
Redox homeostasis
title_short Dietary and microbiome factors determine longevity in Caenorhabditis elegans
title_full Dietary and microbiome factors determine longevity in Caenorhabditis elegans
title_fullStr Dietary and microbiome factors determine longevity in Caenorhabditis elegans
title_full_unstemmed Dietary and microbiome factors determine longevity in Caenorhabditis elegans
title_sort Dietary and microbiome factors determine longevity in Caenorhabditis elegans
dc.creator.none.fl_str_mv Sánchez-Blanco, Adolfo
Rodríguez-Matellán, Alberto G.
González-Paramas, Ana
González-Manzano, Susana
Kim, Stuart K.
Mollinedo, Faustino
author Sánchez-Blanco, Adolfo
author_facet Sánchez-Blanco, Adolfo
Rodríguez-Matellán, Alberto G.
González-Paramas, Ana
González-Manzano, Susana
Kim, Stuart K.
Mollinedo, Faustino
author_role author
author2 Rodríguez-Matellán, Alberto G.
González-Paramas, Ana
González-Manzano, Susana
Kim, Stuart K.
Mollinedo, Faustino
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Instituto de Salud Carlos III
European Commission
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv C. elegans
Longevity
Microbiome
Oxidants
Coenzyme Q
Redox homeostasis
topic C. elegans
Longevity
Microbiome
Oxidants
Coenzyme Q
Redox homeostasis
description Diet composition affects organismal health. Nutrient uptake depends on the microbiome. Caenorhabditis elegans fed a Bacillus subtilis diet live longer than those fed the standard Escherichia coli diet. Here we report that this longevity difference is primarily caused by dietary coQ, an antioxidant synthesized by E. coli but not by B. subtilis. CoQ‐supplemented E. coli fed worms have a lower oxidation state yet live shorter than coQ‐less B. subtilis fed worms. We showed that mutations affecting longevity for E. coli fed worms do not always lead to similar effects when worms are fed B. subtilis. We propose that coQ supplementation by the E. coli diet alters the worm cellular REDOX homeostasis, thus decreasing longevity. Our results highlight the importance of microbiome factors in longevity, argue that antioxidant supplementation can be detrimental, and suggest that the C. elegans standard E. coli diet can alter the effect of signaling pathways on longevity.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/136894
url http://hdl.handle.net/10261/136894
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/256986
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-59716-R
http://dx.doi.org/ 10.18632/aging.101008
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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