Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial

Background: Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computeri...

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Detalles Bibliográficos
Autores: Bermudo Gallaguet, Adrià, Ariza González, Mar, Dacosta-Aguayo, Rosalia, Agudelo, Daniela, Camins-Vila, Neus, Boldó, Maria, Carrera, Òscar, Vidal, Sandra, Ferrer-Uris, Blai, Busquets Faciabén, Albert, Via i García, Marc, Pera, Guillem, Cáceres, Cynthia, Gomis, Meritxell, García-Molina, Alberto, Tormos, José María, Arrabé, Ana, Diez, Gustavo, Durà Mata, Maria José, Torán Monserrat, Pere, Soriano Raya, Juan José, Domènech, Sira, Perera Lluna, Alexandre, Erickson, Kirk I., Mataró Serrat, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/191010
Acceso en línea:https://hdl.handle.net/2445/191010
Access Level:acceso abierto
Palabra clave:Embòlia i trombosi cerebral
Malalties cerebrovasculars
Teràpia cognitiva basada en l'atenció plena
Exercici
Marcadors bioquímics
Cerebral embolism and thrombosis
Cerebrovascular disease
Mindfulness-based cognitive therapy
Exercise
Biochemical markers
Descripción
Sumario:Background: Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. Materials and methods: One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans. Results: The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. Discussion: The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes. Clinical trial registration: www.ClinicalTrials.gov, identifier NCT04759950.

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