Fibroblast growth factors 19 and 21 in acute liver damage

Shan, Z. (Zhao)|||/items/078ddac4-b325-4a3f-89cd-5c003d350a9b; Álvarez-Sola, G. (Gloria)|||/items/3885ae67-b182-4b48-ba48-784d45183c16; Uriarte-Díaz-Varela, I. (Iker)|||/items/607bacbb-b72c-46cd-89fb-455b9f6ddb27; Arechederra, M. (María)|||/items/8db5d239-c664-48b0-9bf7-17aa664dd287; Berasain-Lasarte, C. (Carmen)|||/items/f1d61c19-1753-4442-a3fd-cc90220e84a0; Ju, C. (Cynthia)|||/items/977a9c7b-0f62-4454-aebb-a3dc3d284ae5; Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f; García-Fernández-de-Barrena, M. (Maite)|||/items/cfa77580-40b9-43a4-b237-b234ef7fb6cb

Fibroblast growth factors 19 and 21 in acute liver damage

Currently there are very few pharmacological options available to treat acute liver injury. Because its natural exposure to noxious stimuli the liver has developed a strong endogenous hepatoprotective capacity. Indeed, experimental evidence exposed a variety of endogenous hepatic and systemic respon...

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Autores:	Shan, Z. (Zhao)\|\|\|/items/078ddac4-b325-4a3f-89cd-5c003d350a9b, Álvarez-Sola, G. (Gloria)\|\|\|/items/3885ae67-b182-4b48-ba48-784d45183c16, Uriarte-Díaz-Varela, I. (Iker)\|\|\|/items/607bacbb-b72c-46cd-89fb-455b9f6ddb27, Arechederra, M. (María)\|\|\|/items/8db5d239-c664-48b0-9bf7-17aa664dd287, Berasain-Lasarte, C. (Carmen)\|\|\|/items/f1d61c19-1753-4442-a3fd-cc90220e84a0, Ju, C. (Cynthia)\|\|\|/items/977a9c7b-0f62-4454-aebb-a3dc3d284ae5, Avila, M.A. (Matías Antonio)\|\|\|/items/3ad9abbb-c18d-445b-86cf-cb76be15419f, García-Fernández-de-Barrena, M. (Maite)\|\|\|/items/cfa77580-40b9-43a4-b237-b234ef7fb6cb
Tipo de recurso:	artículo
Fecha de publicación:	2018
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/64494
Acceso en línea:	https://hdl.handle.net/10171/64494
Access Level:	acceso abierto
Palabra clave:	Acute liver injury Fibroblast growth factor 19 (FGF19) Fibroblast growth factor 21 (FGF21)

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spelling	Fibroblast growth factors 19 and 21 in acute liver damageShan, Z. (Zhao)\|\|\|/items/078ddac4-b325-4a3f-89cd-5c003d350a9bÁlvarez-Sola, G. (Gloria)\|\|\|/items/3885ae67-b182-4b48-ba48-784d45183c16Uriarte-Díaz-Varela, I. (Iker)\|\|\|/items/607bacbb-b72c-46cd-89fb-455b9f6ddb27Arechederra, M. (María)\|\|\|/items/8db5d239-c664-48b0-9bf7-17aa664dd287Berasain-Lasarte, C. (Carmen)\|\|\|/items/f1d61c19-1753-4442-a3fd-cc90220e84a0Ju, C. (Cynthia)\|\|\|/items/977a9c7b-0f62-4454-aebb-a3dc3d284ae5Avila, M.A. (Matías Antonio)\|\|\|/items/3ad9abbb-c18d-445b-86cf-cb76be15419fGarcía-Fernández-de-Barrena, M. (Maite)\|\|\|/items/cfa77580-40b9-43a4-b237-b234ef7fb6cbAcute liver injuryFibroblast growth factor 19 (FGF19)Fibroblast growth factor 21 (FGF21)Currently there are very few pharmacological options available to treat acute liver injury. Because its natural exposure to noxious stimuli the liver has developed a strong endogenous hepatoprotective capacity. Indeed, experimental evidence exposed a variety of endogenous hepatic and systemic responses naturally activated to protect the hepatic parenchyma and to foster liver regeneration, therefore preserving individual’s survival. The fibroblast growth factor (FGF) family encompasses a range of polypeptides with important effects on cellular differentiation, growth survival and metabolic regulation in adult organisms. Among these FGFs, FGF19 and FGF21 are endocrine hormones that profoundly influence systemic metabolism but also exert important hepatoprotective activities. In this review, we revisit the biology of these factors and highlight their potential application for the clinical management of acute liver injuryAME PublishingDadun. Depósito Académico Digital Universidad de Navarra20222022-10-1920182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/64494reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/644942026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Fibroblast growth factors 19 and 21 in acute liver damage
title	Fibroblast growth factors 19 and 21 in acute liver damage
spellingShingle	Fibroblast growth factors 19 and 21 in acute liver damage Shan, Z. (Zhao)\|\|\|/items/078ddac4-b325-4a3f-89cd-5c003d350a9b Acute liver injury Fibroblast growth factor 19 (FGF19) Fibroblast growth factor 21 (FGF21)
title_short	Fibroblast growth factors 19 and 21 in acute liver damage
title_full	Fibroblast growth factors 19 and 21 in acute liver damage
title_fullStr	Fibroblast growth factors 19 and 21 in acute liver damage
title_full_unstemmed	Fibroblast growth factors 19 and 21 in acute liver damage
title_sort	Fibroblast growth factors 19 and 21 in acute liver damage
dc.creator.none.fl_str_mv	Shan, Z. (Zhao)\|\|\|/items/078ddac4-b325-4a3f-89cd-5c003d350a9b Álvarez-Sola, G. (Gloria)\|\|\|/items/3885ae67-b182-4b48-ba48-784d45183c16 Uriarte-Díaz-Varela, I. (Iker)\|\|\|/items/607bacbb-b72c-46cd-89fb-455b9f6ddb27 Arechederra, M. (María)\|\|\|/items/8db5d239-c664-48b0-9bf7-17aa664dd287 Berasain-Lasarte, C. (Carmen)\|\|\|/items/f1d61c19-1753-4442-a3fd-cc90220e84a0 Ju, C. (Cynthia)\|\|\|/items/977a9c7b-0f62-4454-aebb-a3dc3d284ae5 Avila, M.A. (Matías Antonio)\|\|\|/items/3ad9abbb-c18d-445b-86cf-cb76be15419f García-Fernández-de-Barrena, M. (Maite)\|\|\|/items/cfa77580-40b9-43a4-b237-b234ef7fb6cb
author	Shan, Z. (Zhao)\|\|\|/items/078ddac4-b325-4a3f-89cd-5c003d350a9b
author_facet	Shan, Z. (Zhao)\|\|\|/items/078ddac4-b325-4a3f-89cd-5c003d350a9b Álvarez-Sola, G. (Gloria)\|\|\|/items/3885ae67-b182-4b48-ba48-784d45183c16 Uriarte-Díaz-Varela, I. (Iker)\|\|\|/items/607bacbb-b72c-46cd-89fb-455b9f6ddb27 Arechederra, M. (María)\|\|\|/items/8db5d239-c664-48b0-9bf7-17aa664dd287 Berasain-Lasarte, C. (Carmen)\|\|\|/items/f1d61c19-1753-4442-a3fd-cc90220e84a0 Ju, C. (Cynthia)\|\|\|/items/977a9c7b-0f62-4454-aebb-a3dc3d284ae5 Avila, M.A. (Matías Antonio)\|\|\|/items/3ad9abbb-c18d-445b-86cf-cb76be15419f García-Fernández-de-Barrena, M. (Maite)\|\|\|/items/cfa77580-40b9-43a4-b237-b234ef7fb6cb
author_role	author
author2	Álvarez-Sola, G. (Gloria)\|\|\|/items/3885ae67-b182-4b48-ba48-784d45183c16 Uriarte-Díaz-Varela, I. (Iker)\|\|\|/items/607bacbb-b72c-46cd-89fb-455b9f6ddb27 Arechederra, M. (María)\|\|\|/items/8db5d239-c664-48b0-9bf7-17aa664dd287 Berasain-Lasarte, C. (Carmen)\|\|\|/items/f1d61c19-1753-4442-a3fd-cc90220e84a0 Ju, C. (Cynthia)\|\|\|/items/977a9c7b-0f62-4454-aebb-a3dc3d284ae5 Avila, M.A. (Matías Antonio)\|\|\|/items/3ad9abbb-c18d-445b-86cf-cb76be15419f García-Fernández-de-Barrena, M. (Maite)\|\|\|/items/cfa77580-40b9-43a4-b237-b234ef7fb6cb
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Acute liver injury Fibroblast growth factor 19 (FGF19) Fibroblast growth factor 21 (FGF21)
topic	Acute liver injury Fibroblast growth factor 19 (FGF19) Fibroblast growth factor 21 (FGF21)
description	Currently there are very few pharmacological options available to treat acute liver injury. Because its natural exposure to noxious stimuli the liver has developed a strong endogenous hepatoprotective capacity. Indeed, experimental evidence exposed a variety of endogenous hepatic and systemic responses naturally activated to protect the hepatic parenchyma and to foster liver regeneration, therefore preserving individual’s survival. The fibroblast growth factor (FGF) family encompasses a range of polypeptides with important effects on cellular differentiation, growth survival and metabolic regulation in adult organisms. Among these FGFs, FGF19 and FGF21 are endocrine hormones that profoundly influence systemic metabolism but also exert important hepatoprotective activities. In this review, we revisit the biology of these factors and highlight their potential application for the clinical management of acute liver injury
publishDate	2018
dc.date.none.fl_str_mv	2018 2018-01-01 2018 2018-01-01 2022 2022-10-19
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/64494
url	https://hdl.handle.net/10171/64494
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	AME Publishing
publisher.none.fl_str_mv	AME Publishing
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.300719

Fibroblast growth factors 19 and 21 in acute liver damage

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