Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization

Background: treatment resistant depression (TRD) is diagnosed when patients experiencing a major depressive episode fail to respond to ≥2 treatments. Along with substantial indirect costs, patients with TRD have higher healthcare resource utilization (HCRU) than other patients with depression. Howev...

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Autores: Heerlein, K., De Giorgi, S., Degraeve, G., Frodl, T., Hagedoorn, W., Oliveira Maia, A. J., Otte, C., Pérez Solà, Víctor, Rathod, S., Rosso, G., Sierra, Pablo, Vita , A., Morrens, J., Rive, B., Mulhern Haughey S., Kambarov, Y., Young, Allan H.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53995
Acceso en línea:http://hdl.handle.net/10230/53995
http://dx.doi.org/10.1016/j.jad.2021.11.004
Access Level:acceso abierto
Palabra clave:Healthcare resource utilization
Major depressive disorder
Observational study
Real-world evidence
Treatment resistant depression
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spelling Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilizationHeerlein, K.De Giorgi, S.Degraeve, G.Frodl, T.Hagedoorn, W.Oliveira Maia, A. J.Otte, C.Pérez Solà, VíctorRathod, S.Rosso, G.Sierra, PabloVita , A.Morrens, J.Rive, B.Mulhern Haughey S.Kambarov, Y.Young, Allan H.Healthcare resource utilizationMajor depressive disorderObservational studyReal-world evidenceTreatment resistant depressionBackground: treatment resistant depression (TRD) is diagnosed when patients experiencing a major depressive episode fail to respond to ≥2 treatments. Along with substantial indirect costs, patients with TRD have higher healthcare resource utilization (HCRU) than other patients with depression. However, research on the economic impact of this HCRU, and differences according to response to treatment, is lacking. Methods: this multicenter, observational study documented HCRU among patients with TRD in European clinical practice initiating new antidepressant treatments. Data regarding access to outpatient consultations and other healthcare resources for the first 6 months, collected using a questionnaire, were analyzed qualitatively according to response and remission status. The economic impact of HCRU, estimated using European costing data, was analyzed quantitatively. Results: among 411 patients, average HCRU was higher in non-responders, attending five times more general practitioner (GP) consultations and spending longer in hospital (1.7 versus 1.1 days) than responders. Greater differences were observed according to remission status, with non-remitters attending seven times more GP consultations and spending approximately three times longer in hospital (1.7 versus 0.6 days) than remitters. Consequently, the estimated economic impacts of non-responders and non-remitters were significantly greater than those of responders and remitters, respectively. Limitations: key limitations are small cohort size, absence of control groups and generalizability to different healthcare systems. Conclusion: patients with TRD, particularly those not achieving remission, have considerable HCRU, with associated economic impact. The costs of unmet TRD treatment needs are thus substantial, and treatment success is fundamental to reduce individual needs and societal costs.Elsevier202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53995http://dx.doi.org/10.1016/j.jad.2021.11.004reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglés0165-0327/© 2021, Heerlein K, De Giorgi S, Degraeve G, Frodl T, Hagedoorn W, Oliveira-Maia AJ. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/539952026-05-29T05:05:01Z
dc.title.none.fl_str_mv Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
title Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
spellingShingle Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
Heerlein, K.
Healthcare resource utilization
Major depressive disorder
Observational study
Real-world evidence
Treatment resistant depression
title_short Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
title_full Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
title_fullStr Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
title_full_unstemmed Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
title_sort Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
dc.creator.none.fl_str_mv Heerlein, K.
De Giorgi, S.
Degraeve, G.
Frodl, T.
Hagedoorn, W.
Oliveira Maia, A. J.
Otte, C.
Pérez Solà, Víctor
Rathod, S.
Rosso, G.
Sierra, Pablo
Vita , A.
Morrens, J.
Rive, B.
Mulhern Haughey S.
Kambarov, Y.
Young, Allan H.
author Heerlein, K.
author_facet Heerlein, K.
De Giorgi, S.
Degraeve, G.
Frodl, T.
Hagedoorn, W.
Oliveira Maia, A. J.
Otte, C.
Pérez Solà, Víctor
Rathod, S.
Rosso, G.
Sierra, Pablo
Vita , A.
Morrens, J.
Rive, B.
Mulhern Haughey S.
Kambarov, Y.
Young, Allan H.
author_role author
author2 De Giorgi, S.
Degraeve, G.
Frodl, T.
Hagedoorn, W.
Oliveira Maia, A. J.
Otte, C.
Pérez Solà, Víctor
Rathod, S.
Rosso, G.
Sierra, Pablo
Vita , A.
Morrens, J.
Rive, B.
Mulhern Haughey S.
Kambarov, Y.
Young, Allan H.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Healthcare resource utilization
Major depressive disorder
Observational study
Real-world evidence
Treatment resistant depression
topic Healthcare resource utilization
Major depressive disorder
Observational study
Real-world evidence
Treatment resistant depression
description Background: treatment resistant depression (TRD) is diagnosed when patients experiencing a major depressive episode fail to respond to ≥2 treatments. Along with substantial indirect costs, patients with TRD have higher healthcare resource utilization (HCRU) than other patients with depression. However, research on the economic impact of this HCRU, and differences according to response to treatment, is lacking. Methods: this multicenter, observational study documented HCRU among patients with TRD in European clinical practice initiating new antidepressant treatments. Data regarding access to outpatient consultations and other healthcare resources for the first 6 months, collected using a questionnaire, were analyzed qualitatively according to response and remission status. The economic impact of HCRU, estimated using European costing data, was analyzed quantitatively. Results: among 411 patients, average HCRU was higher in non-responders, attending five times more general practitioner (GP) consultations and spending longer in hospital (1.7 versus 1.1 days) than responders. Greater differences were observed according to remission status, with non-remitters attending seven times more GP consultations and spending approximately three times longer in hospital (1.7 versus 0.6 days) than remitters. Consequently, the estimated economic impacts of non-responders and non-remitters were significantly greater than those of responders and remitters, respectively. Limitations: key limitations are small cohort size, absence of control groups and generalizability to different healthcare systems. Conclusion: patients with TRD, particularly those not achieving remission, have considerable HCRU, with associated economic impact. The costs of unmet TRD treatment needs are thus substantial, and treatment success is fundamental to reduce individual needs and societal costs.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53995
http://dx.doi.org/10.1016/j.jad.2021.11.004
url http://hdl.handle.net/10230/53995
http://dx.doi.org/10.1016/j.jad.2021.11.004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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